scholarly journals Local Modulation of Single-Atomic Mn Sites for Enhanced Ambient Ammonia Electrosynthesis

ACS Catalysis ◽  
2020 ◽  
pp. 509-516
Author(s):  
Lili Han ◽  
Machuan Hou ◽  
Pengfei Ou ◽  
Hao Cheng ◽  
Zhouhong Ren ◽  
...  
Keyword(s):  
Local Modulation

scholarly journals The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates

2016 ◽  
Vol 212 (7) ◽  
pp. 789-801 ◽  
Author(s):  
Maria J. Pinto ◽  
Pedro L. Alves ◽  
Luís Martins ◽  
Joana R. Pedro ◽  
Hyun R. Ryu ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Proteasome Inhibition ◽  
Ubiquitin Proteasome System ◽  
Presynaptic Terminal ◽  
Ubiquitinated Proteins ◽  
Presynaptic Differentiation ◽  
Intrinsic Mechanism ◽  
Ubiquitin Proteasome ◽  
Presynaptic Assembly ◽  
Local Modulation

Differentiation of the presynaptic terminal is a complex and rapid event that normally occurs in spatially specific axonal regions distant from the soma; thus, it is believed to be dependent on intra-axonal mechanisms. However, the full nature of the local events governing presynaptic assembly remains unknown. Herein, we investigated the involvement of the ubiquitin–proteasome system (UPS), the major degradative pathway, in the local modulation of presynaptic differentiation. We found that proteasome inhibition has a synaptogenic effect on isolated axons. In addition, formation of a stable cluster of synaptic vesicles onto a postsynaptic partner occurs in parallel to an on-site decrease in proteasome degradation. Accumulation of ubiquitinated proteins at nascent sites is a local trigger for presynaptic clustering. Finally, proteasome-related ubiquitin chains (K11 and K48) function as signals for the assembly of presynaptic terminals. Collectively, we propose a new axon-intrinsic mechanism for presynaptic assembly through local UPS inhibition. Subsequent on-site accumulation of proteins in their polyubiquitinated state triggers formation of presynapses.

scholarly journals Macroscopic Versus Microscopic Schottky Barrier Determination at (Au/Pt)/Ge(100): Interfacial Local Modulation

2020 ◽  
Vol 12 (25) ◽  
pp. 28894-28902
Author(s):  
Andrea Gerbi ◽  
Renato Buzio ◽  
Cesar González ◽  
Nicola Manca ◽  
Daniele Marrè ◽  
...  
Keyword(s):  
Schottky Barrier ◽  
Local Modulation

Local Modulation of Skeletal Growth and Bone Modeling in Poultry

1993 ◽  
Vol 123 (suppl_2) ◽  
pp. 317-322 ◽  
Author(s):  
Steven D. Bain ◽  
Bruce A. Watkins
Keyword(s):  
Skeletal Growth ◽  
Bone Modeling ◽  
Local Modulation

scholarly journals Antinociception Induced by Chronic Glucocorticoid Treatment is Correlated to Local Modulation of Spinal Neurotransmitter Content

2009 ◽  
Vol 5 ◽  
pp. 1744-8069-5-41 ◽  
Author(s):  
Filipa Pinto-Ribeiro ◽  
Vitor Moreira ◽  
José M Pěgo ◽  
Pedro Leão ◽  
Armando Almeida ◽  
...  
Keyword(s):  
Glucocorticoid Treatment ◽  
Local Modulation

scholarly journals Histochemical structure and immunolocalisation of the hyaluronan system in the dromedary oviduct

2016 ◽  
Vol 28 (7) ◽  
pp. 936 ◽  
Author(s):  
Omnia Mohey-Elsaeed ◽  
Waleed F. A. Marei ◽  
Ali A. Fouladi-Nashta ◽  
Abdel-Aleem A. El-Saba
Keyword(s):  
Epithelial Cells ◽  
Molecular Size ◽  
Blue Staining ◽  
Secretory Cells ◽  
Alcian Blue Staining ◽  
Basal Region ◽  
Epithelial Surface ◽  
Ciliated Epithelial Cells ◽  
Oviductal Fluid ◽  
Local Modulation

We investigated the local modulation of some histochemical properties of oviducts of the dromedary (Camelus dromedarius), focusing on the immnolocalisation of hyaluronic acid (HA) synthases (HAS2 and HAS3), hyaluronidases (HYAL2 and HYAL1) and the HA receptor CD44 in the ampulla and isthmus. Abundant acidic mucopolysaccharides (glycosaminoglycans) were detected by Alcian blue staining along the luminal surface of both ciliated and non-ciliated epithelial cells (LE). Staining for HAS2 was higher in the primary epithelial folds of the ampulla compared with the isthmus, especially in secretory cells, adluminal epithelial surface and supranuclear cell domain. HAS3 staining was stronger in the LE of the isthmus than ampulla. HYAL2 was detected in the LE in the ampulla and isthmus and was more intense in the adluminal projections of secretory cells. HYAL1 was weakly detected in the LE with no difference between the ampulla and isthmus. Strong CD44 immunostaining was present in the LE of the ampulla and isthmus. CD44 staining was higher in secretory cells than in ciliated epithelial cells and was higher in the supranuclear region than the basal region of the cytoplasm. In conclusion, we provide evidence that HA synthesis and turnover occur in the camel oviduct. Differences in HAS2 and HAS3 expression suggest regional differences in the molecular size of HA secreted in oviductal fluid that may influence oviduct–gamete interaction in the camel.

scholarly journals CH3NH3PbI3 perovskite single crystals: surface photophysics and their interaction with the environment

2015 ◽  
Vol 6 (12) ◽  
pp. 7305-7310 ◽  
Author(s):  
G. Grancini ◽  
V. D'Innocenzo ◽  
E. R. Dohner ◽  
N. Martino ◽  
A. R. Srimath Kandada ◽  
...  
Keyword(s):  
Single Crystal ◽  
Band Gap ◽  
Single Crystals ◽  
Optical Band Gap ◽  
Structural Inhomogeneity ◽  
Highly Sensitive ◽  
Micrometer Scale ◽  
Local Modulation

Structural inhomogeneity on a micrometer-scale across a CH3NH3PbI3 single crystal is responsible for a local modulation of the optical band gap, which is also highly sensitive to humidity.

scholarly journals Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells

2011 ◽  
Vol 41 (12) ◽  
pp. 3553-3563 ◽  
Author(s):  
Scott K. Pruitt ◽  
David Boczkowski ◽  
Nicole de Rosa ◽  
N. Rebecca Haley ◽  
Michael A. Morse ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Immunity ◽  
Local Modulation
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