Co-delivery of Chemotherapeutic Drugs and Immune Adjuvants by Nanoscale DNA Tetrahedrons for Synergistic Cancer Therapy

2022 ◽  
Author(s):  
Qian Wang ◽  
Yuxuan Ma ◽  
Zhangwei Lu ◽  
Hanyang Yu ◽  
Zhe Li
Keyword(s):  
Cancer Therapy ◽  
Chemotherapeutic Drugs ◽  
Immune Adjuvants

Exploring Nanoemulsion for Liver Cancer Therapy

2020 ◽  
Vol 16 (4) ◽  
pp. 260-268
Author(s):  
Tanmay Upadhyay ◽  
Vaseem A. Ansari ◽  
Usama Ahmad ◽  
Nazneen Sultana ◽  
Juber Akhtar
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Treatment Plan ◽  
Chemotherapeutic Drugs ◽  
Drug Delivery Vehicles ◽  
Chronic Hepatitis B Virus ◽  
Anti Cancer ◽  
B Virus ◽  
Delivery Vehicles ◽  
Liquid Dosage Form

Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. Among these, at least 0.78 million people died of liver cancer alone. The recognized risk factors for liver cancer include chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, exposure to dietary aflatoxin, fatty liver disease, alcohol-induced cirrhosis, obesity, smoking, diabetes, and iron overload. The treatment plan for early diagnosed patients includes radiation therapy, tumour ablation, surgery, immunotherapy, and chemotherapy. Some sort of drug delivery vehicles has to be used when the treatment plan is targeted chemotherapy. Nanoemulsions are a class of biphasic liquid dosage form which are mixtures of oil and water stabilized by a surfactant. They are either transparent or bluish in hue and serve as a wonderful carrier system for chemotherapeutic drugs. These vehicles have a particle size in the range of 20-200 nm allowing them to be delivered successfully in the deepest of tissues. Recent publications on nanoemulsions reveal their acceptance and a popular choice for delivering both synthetic and herbal drugs to the liver. This work focuses on some anti-cancer agents that utilized the advantages of nanoemulsion for liver cancer therapy.

scholarly journals Using Chitosan or Chitosan Derivatives in Cancer Therapy

2021 ◽  
Vol 2 (4) ◽  
pp. 795-816
Author(s):  
Md Salman Shakil ◽  
Kazi Mustafa Mahmud ◽  
Mohammad Sayem ◽  
Mahruba Sultana Niloy ◽  
Sajal Kumar Halder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
Chitosan Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Chitosan Derivatives ◽  
Drug Delivery Vehicles ◽  
Modified Chitosan ◽  
Therapeutic Benefits ◽  
Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

Smart injectable biogels based on hyaluronic acid bioconjugates finely substituted with poly(β-amino ester urethane) for cancer therapy

2019 ◽  
Vol 7 (12) ◽  
pp. 5424-5437 ◽  
Author(s):  
Thavasyappan Thambi ◽  
V. H. Giang Phan ◽  
Seong Han Kim ◽  
Thai Minh Duy Le ◽  
Huu Thuy Trang Duong ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Chemotherapeutic Drugs ◽  
Amino Ester

In situ-forming injectable biogels (IBGs) have been developed for the programmed delivery of potent chemotherapeutic drugs.

scholarly journals Cancer Therapy Challenge: It Is Time to Look in the “St. Patrick’s Well” of the Nature

2021 ◽  
Vol 22 (19) ◽  
pp. 10380
Author(s):  
Gregorio Bonsignore ◽  
Mauro Patrone ◽  
Federica Grosso ◽  
Simona Martinotti ◽  
Elia Ranzato
Keyword(s):  
Drug Discovery ◽  
Cancer Therapy ◽  
Cause Of Death ◽  
Therapeutic Efficacy ◽  
Natural Compounds ◽  
Chemotherapeutic Drugs ◽  
Therapy Approach ◽  
Drug Concentrations ◽  
Interesting Approach ◽  
Different Origins

Cancer still remains a leading cause of death despite improvements in diagnosis, drug discovery and therapy approach. Therefore, there is a strong need to improve methodologies as well as to increase the number of approaches available. Natural compounds of different origins (i.e., from fungi, plants, microbes, etc.) represent an interesting approach for fighting cancer. In particular, synergistic strategies may represent an intriguing approach, combining natural compounds with classic chemotherapeutic drugs to increase therapeutic efficacy and lower the required drug concentrations. In this review, we focus primarily on those natural compounds utilized in synergistic approached to treating cancer, with particular attention to those compounds that have gained the most research interest.

Plant Polyphenolic Compounds Potentiates Therapeutic Efficiency of Anticancer Chemotherapeutic Drugs: A Review.

2020 ◽  
Vol 20 ◽  
Author(s):  
Lokanatha Oruganti ◽  
Balaji Meriga
Keyword(s):  
Cancer Therapy ◽  
Adverse Effects ◽  
Combination Therapy ◽  
Synergistic Effects ◽  
Chemotherapeutic Agents ◽  
Polyphenolic Compounds ◽  
Systematic Research ◽  
Chemotherapeutic Drugs ◽  
Pharmaceutical Ingredients ◽  
Potential Synergy

Background: Scientific research continues to develop more efficacious drugs to treat and cure cancer, the dreadful disease threatening the human race. Chemotherapy is an essential means in cancer therapy, however, plant drugs having pharmacological safety, can be used alone or as additions to current chemotherapeutic agents to enhance therapeutic efficacy and minimize chemotherapy-induced adverse effects. Objective: A combination therapy where the synergistic effect on multiple targets is possible has gained significance, because since a one-drug one-target approach fails to yield the desired therapeutic effect. Therefore, a detailed description of important plant polyphenolic compounds with anticancer activity and their role in potentiating chemotherapeutic efficiency of existing anticancer drugs is provided in this review. Systematically screening combinations of active pharmaceutical ingredients for potential synergy with plant compounds may be especially valuable in cancer therapy. Methodology: We extensively have gone through reviews and research articles available in the literature. We made use of databases such as Google Scholar, Research Gate, PubMed, Science Direct, etc. The following keywords were used in our literature search: “Chemotherapy, drug development, cancer drugs, plant-derived polyphenolics, synergistic studies, combination therapy, diagnosis and genetics.” Conclusion: Systematic research studies on screening combinations of plant phytochemicals with potential chemotherapeutic pharmaceuticals throws light on their synergistic effects, mechanisms of actions paving the way to develop more efficient anticancer therapeutics to treat and cure the cancer menace, to nullify chemotherapy-induced adverse effects and our review substantially contributes in this direction.

Transferrin-conjugated paclitaxel prodrugs for targeted cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77987-77998 ◽  
Author(s):  
Lingling Shan ◽  
Xin Shan ◽  
Tinging Zhang ◽  
Kefeng Zhai ◽  
Guizhen Gao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Wide Spectrum ◽  
Targeted Cancer Therapy ◽  
Chemotherapeutic Drugs

Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs ever developed and is effective against a wide spectrum of tumors.

scholarly journals Chemotherapeutic, Toxin, and Therapeutic Protein Delivery via Nucleolin Aptamer-functionalized Nanoplatforms for Targeted Cancer Therapy

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Pouya Safarzadeh Kozani ◽  
Pooria Safarzadeh Kozani ◽  
Fatemeh Rahbarizadeh
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Protein Delivery ◽  
Therapeutic Potential ◽  
Therapeutic Protein ◽  
Targeted Cancer Therapy ◽  
Chemotherapeutic Drugs ◽  
Different Types ◽  
As1411 Aptamer ◽  
Targeting Peptide

: Nucleolin is a protein abundantly present in the nucleolus, but its expression on the surface of cells is potentially associated with various types of malignancies. So far, several nucleolin-targeting strategies, including the nucleolin-targeting peptide, anti-nucleolin pseudopeptides, anti-nucleolin antibodies, and the anti-nucleolin aptamer, AS1411, have been developed and investigated in different types of studies. The AS1411 aptamer has been known as the outstanding approach for targeting nucleolin with superior specificity and therapeutic potential in comparison with other targeting strategies. In this review, we highlight different nucleolin-targeting strategies for the targeted delivery of chemotherapeutic drugs, proteins with therapeutic potential, and toxins.

Sign in / Sign up

Export Citation Format

Share Document