Lipid-Encapsulated Fe3O4 Nanoparticles for Multimodal Magnetic Resonance/Fluorescence Imaging

2020 ◽  
Vol 3 (7) ◽  
pp. 6785-6797
Author(s):  
Linlin Zhang ◽  
Sheng Tong ◽  
Qingbo Zhang ◽  
Gang Bao
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ruoxi Xie ◽  
Zijun Wu ◽  
Fanxin Zeng ◽  
Huawei Cai ◽  
Dan Wang ◽  
...  

AbstractGlioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or DANG) to locate malignant gliomas and guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro, and both could mediate precise aggregation of the nanoprobes at gliomas sites in in vivo magnetic resonance imaging (MRI) and ex vivo near-infrared (NIR) fluorescence imaging. However, compared with ANG/Cy7-SPIONs probes, DANG/Cy7-SPIONs probes exhibited better enhanced MR imaging effects. Combining all these features together, this MRI/NIR fluorescence imaging dual-modal nanoprobes modified with retro-enantio isomers of the peptide have the potential to accurately display GBMs preoperatively for precise imaging and intraoperatively for real-time imaging.


2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2010.00049 ◽  
Author(s):  
Yusuke Inoue ◽  
Yoshitaka Masutani ◽  
Shigeru Kiryu ◽  
Tomoyuki Haishi ◽  
Kohki Yoshikawa ◽  
...  

1999 ◽  
Vol 86 (10) ◽  
pp. 5337-5341 ◽  
Author(s):  
A. A. Podshivalov ◽  
M. R. Shepard ◽  
O. I. Matveev ◽  
B. W. Smith ◽  
J. D. Winefordner

2011 ◽  
Vol 23 (36) ◽  
pp. H248-H253 ◽  
Author(s):  
Joseph M. Kinsella ◽  
Shalini Ananda ◽  
Jennifer S. Andrew ◽  
Joel F. Grondek ◽  
Miao-Ping Chien ◽  
...  

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