Synergistically Enhance Magnetic Resonance/Fluorescence Imaging Performance of Responsive Polymeric Nanoparticles Under Mildly Acidic Biological Milieu

2012 ◽  
Vol 34 (9) ◽  
pp. 749-758 ◽  
Author(s):  
Jinming Hu ◽  
Tao Liu ◽  
Guoying Zhang ◽  
Fan Jin ◽  
Shiyong Liu
Keyword(s):  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Polymeric Nanoparticles ◽  
Resonance Fluorescence ◽  
Imaging Performance ◽  
Biological Milieu

Lipid-Encapsulated Fe3O4 Nanoparticles for Multimodal Magnetic Resonance/Fluorescence Imaging

2020 ◽  
Vol 3 (7) ◽  
pp. 6785-6797
Author(s):  
Linlin Zhang ◽  
Sheng Tong ◽  
Qingbo Zhang ◽  
Gang Bao
Keyword(s):  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Fe3o4 Nanoparticles ◽  
Resonance Fluorescence

scholarly journals Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ruoxi Xie ◽  
Zijun Wu ◽  
Fanxin Zeng ◽  
Huawei Cai ◽  
Dan Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Ex Vivo ◽  
Malignant Gliomas ◽  
Resonance Fluorescence ◽  
Malignant Tumours ◽  
Nir Fluorescence

AbstractGlioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or DANG) to locate malignant gliomas and guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro, and both could mediate precise aggregation of the nanoprobes at gliomas sites in in vivo magnetic resonance imaging (MRI) and ex vivo near-infrared (NIR) fluorescence imaging. However, compared with ANG/Cy7-SPIONs probes, DANG/Cy7-SPIONs probes exhibited better enhanced MR imaging effects. Combining all these features together, this MRI/NIR fluorescence imaging dual-modal nanoprobes modified with retro-enantio isomers of the peptide have the potential to accurately display GBMs preoperatively for precise imaging and intraoperatively for real-time imaging.

The influence of confocal microscope design on imaging performance

1993 ◽  
Vol 51 ◽  
pp. 144-145
Author(s):  
C J R Sheppard
Keyword(s):  
Image Quality ◽  
Fluorescence Imaging ◽  
Confocal Microscope ◽  
Industrial Applications ◽  
Three Dimensions ◽  
Design Parameters ◽  
Weak Signals ◽  
Size And Shape ◽  
Imaging Performance ◽  
Fundamental Limitation

The confocal microscope is now widely used in both biomedical and industrial applications for imaging, in three dimensions, objects with appreciable depth. There are now a range of different microscopes on the market, which have adopted a variety of different designs. The aim of this paper is to explore the effects on imaging performance of design parameters including the method of scanning, the type of detector, and the size and shape of the confocal aperture.It is becoming apparent that there is no such thing as an ideal confocal microscope: all systems have limitations and the best compromise depends on what the microscope is used for and how it is used. The most important compromise at present is between image quality and speed of scanning, which is particularly apparent when imaging with very weak signals. If great speed is not of importance, then the fundamental limitation for fluorescence imaging is the detection of sufficient numbers of photons before the fluorochrome bleaches.

scholarly journals Integrated Lymphography using Fluorescence Imaging and Magnetic Resonance Imaging in Intact Mice

2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2010.00049 ◽  
Author(s):  
Yusuke Inoue ◽  
Yoshitaka Masutani ◽  
Shigeru Kiryu ◽  
Tomoyuki Haishi ◽  
Kohki Yoshikawa ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Resonance Imaging

Ultrahigh-resolution, frequency-resolved resonance fluorescence imaging with a monoisotopic mercury atom cell

1999 ◽  
Vol 86 (10) ◽  
pp. 5337-5341 ◽  
Author(s):  
A. A. Podshivalov ◽  
M. R. Shepard ◽  
O. I. Matveev ◽  
B. W. Smith ◽  
J. D. Winefordner
Keyword(s):  
Fluorescence Imaging ◽  
Mercury Atom ◽  
Resonance Fluorescence ◽  
Ultrahigh Resolution
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