High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

2018 ◽  
Vol 10 (33) ◽  
pp. 27692-27700 ◽  
Author(s):  
Can Zhang ◽  
Kaili Liang ◽  
Ding Zhou ◽  
Hongjun Yang ◽  
Xin Liu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Vinyl Alcohol ◽  
High Performance ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels ◽  
Silica Nanocomposite

scholarly journals Macrophages, the main marker in biocompatibility evaluation of new hydrogels after subcutaneous implantation in rats

2021 ◽  
pp. 088532822110461
Author(s):  
Tijana Lužajić Božinovski ◽  
Vera Todorović ◽  
Ivan Milošević ◽  
Bogomir Bolka Prokić ◽  
Vladimir Gajdov ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Giant Cells ◽  
Surface Interactions ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels ◽  
Tissue Sections ◽  
Biological Responses ◽  
Statistical Relevance ◽  
Biomaterial Surface

Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage–biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] in vivo, with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68+). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb© material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.

Graphene-reinforced poly(vinyl alcohol) electrospun fibers as building blocks for high performance nanocomposites

RSC Advances ◽  
2015 ◽  
Vol 5 (103) ◽  
pp. 85009-85018 ◽  
Author(s):  
Sajjad Ghobadi ◽  
Sina Sadighikia ◽  
Melih Papila ◽  
Fevzi Çakmak Cebeci ◽  
Selmiye Alkan Gürsel
Keyword(s):  
Polymer Matrix ◽  
Vinyl Alcohol ◽  
High Performance ◽  
Building Blocks ◽  
Poly Vinyl Alcohol ◽  
Electrospun Fibers ◽  
Matrix Solution ◽  
High Level

Graphene-containing fibrous structures with a high level of affinity towards a polymer matrix solution have been proved to be promising for high performance macroscopic nanocomposite reinforcement purposes.

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