scholarly journals Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

2018 ◽  
Vol 57 (18) ◽  
pp. 1882-1889 ◽  
Author(s):  
Ding Zhou ◽  
Qi Dong ◽  
Kaili Liang ◽  
Weilin Xu ◽  
Yingshan Zhou ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels

High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

2018 ◽  
Vol 10 (33) ◽  
pp. 27692-27700 ◽  
Author(s):  
Can Zhang ◽  
Kaili Liang ◽  
Ding Zhou ◽  
Hongjun Yang ◽  
Xin Liu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Vinyl Alcohol ◽  
High Performance ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels ◽  
Silica Nanocomposite

Tailoring the in vitro characteristics of poly(vinyl alcohol)-nanohydroxyapatite composite scaffolds for bone tissue engineering

2016 ◽  
Vol 36 (8) ◽  
pp. 771-784 ◽  
Author(s):  
Tejinder Kaur ◽  
Arunachalam Thirugnanam ◽  
Krishna Pramanik
Keyword(s):  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Contact Angle Measurement ◽  
Angle Measurement ◽  
Poly Vinyl Alcohol ◽  
Apatite Formation ◽  
Composite Scaffolds ◽  
Alizarin Red ◽  
Casting Technique

Abstract Poly(vinyl alcohol) reinforced with nanohydroxyapatite (PVA-nHA) composite scaffolds were developed by varying the nHA (1%, 2%, 3%, 4%, and 5%, w/v) composition in the PVA matrix by solvent casting technique. The developed composite scaffolds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, and contact angle measurement. The stability of the composite scaffolds in physiological environment was evaluated by swelling and degradation studies. Further, these composite scaffolds were tested for in vitro bioactivity, hemolysis, biocompatibility, and mechanical strength. SEM micrographs showed a homogenous distribution of nHA (3%, w/v) in the PVA matrix. XRD and ATR-FTIR analysis confirmed no phase contamination and the existence of the chemical bond between PVA-nHA at approximately 2474 cm-1. PVA-nHA composite scaffolds with 3% (w/v) concentration of nHA showed nominal swelling and degradation behavior with good mechanical strength. The mechanical strength and degradation properties of the scaffold above 3% (w/v) of nHA was found to deteriorate, which is due to the agglomeration of nHA. The in vitro bioactivity and hemolysis studies showed improved apatite formation and hemocompatibility of the developed scaffolds. In vitro cell adhesion, proliferation, alkaline phosphatase activity, and Alizarin red S staining confirmed the biocompatibility of the composite scaffolds.

scholarly journals Macrophages, the main marker in biocompatibility evaluation of new hydrogels after subcutaneous implantation in rats

2021 ◽  
pp. 088532822110461
Author(s):  
Tijana Lužajić Božinovski ◽  
Vera Todorović ◽  
Ivan Milošević ◽  
Bogomir Bolka Prokić ◽  
Vladimir Gajdov ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Giant Cells ◽  
Surface Interactions ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels ◽  
Tissue Sections ◽  
Biological Responses ◽  
Statistical Relevance ◽  
Biomaterial Surface

Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage–biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] in vivo, with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68+). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb© material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.

Improving the Processing Ability and Mechanical Strength of Starch/Poly(vinyl alcohol) Blends through Plasma and Acid Modification

2008 ◽  
Vol 272 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Sung-Yeng Yang ◽  
Chia-I Liu ◽  
Jing-Yi Wu ◽  
Ju-Chien Kuo ◽  
Chi-Yuan Huang
Keyword(s):  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Acid Modification ◽  
Processing Ability

scholarly journals Effect of Junction Length in Poly(vinyl alcohol) Physical Gel on Mechanical Strength

2009 ◽  
Vol 66 (9) ◽  
pp. 349-354 ◽  
Author(s):  
Hidenobu SHIMIZU ◽  
Risei WADA ◽  
Masaru OKABE
Keyword(s):  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Physical Gel
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