Injectable Hydrogel Capable of In Situ Covalent Crosslinking for Permanent Embolization

2021 ◽  
Author(s):  
Ruosen Xie ◽  
Yu-Chung Chen ◽  
Yi Zhao ◽  
Nisakorn Yodsanit ◽  
Yuyuan Wang ◽  
...  
Keyword(s):  
Injectable Hydrogel ◽  
Covalent Crosslinking

Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

2019 ◽  
Vol 7 (15) ◽  
pp. 2442-2453 ◽  
Author(s):  
Caoxin Tang ◽  
Brian D. Holt ◽  
Zoe M. Wright ◽  
Anne M. Arnold ◽  
Alexandra C. Moy ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Functionalized Graphene ◽  
Injectable Hydrogel ◽  
Amine Functionalized ◽  
Cartilage Therapy

Chemically functionalized graphene covalently reactsin situwith chondroitin sulfate to form an enhanced, injectable hydrogel for potential cartilage therapy.

A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel

Nano LIFE ◽  
2014 ◽  
Vol 04 (03) ◽  
pp. 1441001 ◽  
Author(s):  
Jun Chen ◽  
Xiaojian Li ◽  
Liqian Gao ◽  
Yi Hu ◽  
Wen Zhong ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Controlled Delivery ◽  
Cell Uptake ◽  
Injectable Hydrogel ◽  
Poorly Soluble ◽  
Poly Ethylene ◽  
Novel Strategy ◽  
Ph Sensitive Polymer ◽  
Tunable Stiffness

In light of the challenges along with the traditional intravenous administration of chemotherapeutics, injectable hydrogel-drug system emerges as a powerful tool for noninvasive and in situ controlled-release of drugs. Herein, we report a novel strategy of drug delivery system with pH responsive injectable hydrogels by taking advantages of two biomaterials. The first one is a pH sensitive polymer-drug (prodrug) conjugate, poly (ethylene glycol)–doxorubicin (MPEG–DOX) with hydrazone linkage. This prodrug interacted with a second biomaterial, α-cyclodextrin (α-CD) under mild conditions and subsequently formed the hydrogels in minutes with tunable stiffness. The gels showed a sustained release behavior dependent on the surrounding pH and released drugs effectively killed tumor cells (MCF-7). The quick cell uptake and efficient intracellular delivery of DOX were observed under a confocal microscope. This study thus provides a novel and simple drug encapsulation strategy to deliver poorly soluble drugs in situ for a potential targeted chemotherapy.

A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis

Biomaterials ◽  
2017 ◽  
Vol 134 ◽  
pp. 128-142 ◽  
Author(s):  
Yanxian Feng ◽  
Qiu Li ◽  
Dang Wu ◽  
Yiming Niu ◽  
Cheng Yang ◽  
...  
Keyword(s):  
Growth Factors ◽  
Endogenous Growth ◽  
Injectable Hydrogel

Precise in-situ release of microRNA from an injectable hydrogel induces bone regeneration

2021 ◽  
Author(s):  
Minfeng Gan ◽  
Quan Zhou ◽  
Jun Ge ◽  
Jiali Zhao ◽  
Yingjie Wang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Injectable Hydrogel

scholarly journals Development of an in situ injectable hydrogel containing hyaluronic acid for neural regeneration

2020 ◽  
Vol 15 (5) ◽  
pp. 055005 ◽  
Author(s):  
Linh T B Nguyen ◽  
Chia-Chen Hsu ◽  
Hua Ye ◽  
Zhanfeng Cui
Keyword(s):  
Hyaluronic Acid ◽  
Neural Regeneration ◽  
Injectable Hydrogel

Dually Responsive Injectable Hydrogel Prepared by In Situ Cross-Linking of Glycol Chitosan and Benzaldehyde-Capped PEO-PPO-PEO

2010 ◽  
Vol 11 (4) ◽  
pp. 1043-1051 ◽  
Author(s):  
Caixia Ding ◽  
Lingling Zhao ◽  
Fuyong Liu ◽  
Jun Cheng ◽  
Jingxia Gu ◽  
...  
Keyword(s):  
Cross Linking ◽  
Glycol Chitosan ◽  
Injectable Hydrogel

A pH- and temperature-responsive bioresorbable injectable hydrogel based on polypeptide block copolymers for the sustained delivery of proteins in vivo

2018 ◽  
Vol 6 (3) ◽  
pp. 661-671 ◽  
Author(s):  
Md. Hasan Turabee ◽  
Thavasyappan Thambi ◽  
Huu Thuy Trang Duong ◽  
Ji Hoon Jeong ◽  
Doo Sung Lee
Keyword(s):  
Block Copolymers ◽  
Controlled Delivery ◽  
Sustained Delivery ◽  
Injectable Hydrogel ◽  
Temperature Responsive

A pH- and temperature-responsive in situ-forming injectable hydrogel based on comb-type polypeptide block copolymers for the controlled delivery of proteins has been developed.

scholarly journals Covalent crosslinking of graphene oxide and carbon nanotube into hydrogels enhances nerve cell responses

2016 ◽  
Vol 4 (43) ◽  
pp. 6930-6941 ◽  
Author(s):  
Xifeng Liu ◽  
A. Lee Miller II ◽  
Sungjo Park ◽  
Brian E. Waletzki ◽  
Andre Terzic ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Carbon Nanotube ◽  
Nerve Cell ◽  
Neurite Growth ◽  
Cell Responses ◽  
Covalent Crosslinking

Chemically crosslinking GOa and CNTpega followed by in situ reduction fabricated a conductive rGOa–CNTpega–OPF hydrogel that strongly stimulated neurite growth.

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