In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors

2021 ◽  
Author(s):  
Syed Baseeruddin Alvi ◽  
Rajalakshmi P S ◽  
Nazia Begum ◽  
Anil Bankati Jogdand ◽  
Bantal Veeresh ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Photothermal Therapy ◽  
Metastatic Tumors

Laboratory Testing for HER2/neu in Breast Carcinoma: An Evolving Strategy to Predict Response to Targeted Therapy

2001 ◽  
Vol 8 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Nils M. Diaz
Keyword(s):  
Targeted Therapy ◽  
Breast Carcinoma ◽  
Gene Amplification ◽  
Laboratory Testing ◽  
False Positives ◽  
Response To Therapy ◽  
Fish Analysis ◽  
Breast Carcinomas ◽  
Testing Strategies

Background Laboratory testing of HER2/neu in breast carcinoma has become vital to patient care following the approval of trastuzumab as the first therapy to target the HER2/neu oncoprotein. Initial clinical trials used immunohistochemistry (IHC) to test for HER2/neu overexpression in order to select patients for therapy. Fluorescence in situ hybridization (FISH), which tests for gene amplification, is more specific and sensitive than IHC when either assay is compared with HER2/neu overexpression as determined by Northern or Western blot analysis. Many weak overexpressors on IHC testing are not gene amplified on FISH analysis. Such weak overexpressors may be considered false-positives and raise the question of how best to test for HER2/neu. Methods The literature was surveyed regarding testing for HER2/neu overexpression in breast carcinomas and alternative testing strategies. Results False-positive results are a significant problem when IHC is exclusively used to test for HER2/neu overexpression. The false-positives are overwhelmingly confined to the group of 2+ positives and do not respond to targeted therapy. In contrast, concordance between IHC and FISH is high when immunostaining is interpreted as either negative or strongly positive (3+). Whereas some recent studies have suggested that FISH may better predict response to anti-HER2/neu therapy than IHC, others have indicated that IHC is as effective a predictor as FISH. IHC is less technically demanding and costly than FISH. Conclusions IHC analysis of HER2/neu in breast carcinoma is a useful predictor of response to therapy with trastuzumab when strongly positive. Negative immunostaining is highly concordant with a lack of gene amplification by FISH. Most weakly positive overexpressors are false-positives on testing with FISH. Thus, screening of breast carcinomas with IHC and confirmation of weakly positive IHC results by FISH is an effective evolving strategy for testing HER2/neu as a predictor of response to targeted therapy.

Cancer photothermal therapy based on near infrared fluorescence CdSeTe/ZnS quantum dots

2021 ◽  
Author(s):  
Jin Wang ◽  
Xueqiong Su ◽  
Pengxiang Zhao ◽  
Dongwen Gao ◽  
Ruixiang Chen ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Targeted Therapy ◽  
Human Body ◽  
Early Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Near Infrared Fluorescence

Micro targeted therapy for cancer has become a hot topic in recent years because of its advantages of small damage to human body and early treatment of cancer. Therefore, accurate,...

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine-IR820 Prodrug Encapsulated ZIF-8 toward Chemo-Photothermal Therapy

2018 ◽  
Vol 28 (35) ◽  
pp. 1802830 ◽  
Author(s):  
Huiyuan Zhang ◽  
Qian Li ◽  
Ruiling Liu ◽  
Xinke Zhang ◽  
Zhonghao Li ◽  
...  
Keyword(s):  
Photothermal Therapy

An injectable nanocomposite hydrogel co-constructed with gold nanorods and paclitaxel-loaded nanoparticles for local chemo-photothermal synergetic cancer therapy

2019 ◽  
Vol 7 (16) ◽  
pp. 2667-2677 ◽  
Author(s):  
Meiyan Liu ◽  
Pingsheng Huang ◽  
Weiwei Wang ◽  
Zujian Feng ◽  
Jianhua Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Nanocomposite Hydrogel ◽  
Tumor Inhibition

A nanocomposite hydrogel, AuNR/PTXmPECTgel, was fabricated for in situ synergetic chemotherapy and photothermal therapy for tumor inhibition.

Acid-Triggered in Situ Aggregation of Gold Nanoparticles for Multimodal Tumor Imaging and Photothermal Therapy

2019 ◽  
Vol 5 (3) ◽  
pp. 1589-1601 ◽  
Author(s):  
Yumin Zhang ◽  
Jinglin Chang ◽  
Fan Huang ◽  
Lijun Yang ◽  
Chunhua Ren ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Tumor Imaging
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