A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine-IR820 Prodrug Encapsulated ZIF-8 toward Chemo-Photothermal Therapy

2018 ◽  
Vol 28 (35) ◽  
pp. 1802830 ◽  
Author(s):  
Huiyuan Zhang ◽  
Qian Li ◽  
Ruiling Liu ◽  
Xinke Zhang ◽  
Zhonghao Li ◽  
...  
Keyword(s):  
Photothermal Therapy

An injectable nanocomposite hydrogel co-constructed with gold nanorods and paclitaxel-loaded nanoparticles for local chemo-photothermal synergetic cancer therapy

2019 ◽  
Vol 7 (16) ◽  
pp. 2667-2677 ◽  
Author(s):  
Meiyan Liu ◽  
Pingsheng Huang ◽  
Weiwei Wang ◽  
Zujian Feng ◽  
Jianhua Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Nanocomposite Hydrogel ◽  
Tumor Inhibition

A nanocomposite hydrogel, AuNR/PTXmPECTgel, was fabricated for in situ synergetic chemotherapy and photothermal therapy for tumor inhibition.

Acid-Triggered in Situ Aggregation of Gold Nanoparticles for Multimodal Tumor Imaging and Photothermal Therapy

2019 ◽  
Vol 5 (3) ◽  
pp. 1589-1601 ◽  
Author(s):  
Yumin Zhang ◽  
Jinglin Chang ◽  
Fan Huang ◽  
Lijun Yang ◽  
Chunhua Ren ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Tumor Imaging

In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (35) ◽  
pp. 12885-12896 ◽  
Author(s):  
Ruoyan Wei ◽  
Wensong Xi ◽  
Haifang Wang ◽  
Jinliang Liu ◽  
Torsten Mayr ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Photothermal Therapy ◽  
Upconversion Nanoparticles ◽  
Ph Responsive ◽  
Gold Nanocrystals

A multifunctional nanocomposite was synthesized by linking pH-responsive prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles, which is bioimaging-guided multifunctional synergistic therapy agent.

In situ tuning of gold nanorod plasmon through oxidative cyanide etching

2016 ◽  
Vol 18 (23) ◽  
pp. 15619-15624 ◽  
Author(s):  
Aquiles Carattino ◽  
Saumyakanti Khatua ◽  
Michel Orrit
Keyword(s):  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Red Shift ◽  
Gold Nanorod

Single gold nanorods exhibit great opportunities for bio-sensing, enhanced spectroscopies and photothermal therapy. We show how to red-shift the plasmon resonance of single nanorods controllably.

scholarly journals Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lihua Luo ◽  
Bing Qin ◽  
Mengshi Jiang ◽  
Lin Xie ◽  
Zhenyu Luo ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Cells ◽  
Cd8 T Cells ◽  
Photothermal Therapy ◽  
Cd8 T Cell ◽  
Immune Memory ◽  
In Situ Vaccine

Abstract Background Photothermal therapy (PTT) is a highly effective treatment for solid tumors and can induce long-term immune memory worked like an in situ vaccine. Nevertheless, PTT inevitably encounters photothermal resistance of tumor cells, which hinders therapeutic effect or even leads to tumor recurrence. Naïve CD8+ T cells are mainly metabolized by oxidative phosphorylation (OXPHOS), followed by aerobic glycolysis after activation. And the differentiate of effector CD8+ T cell (CD8+ Teff) into central memory CD8+ T cell (CD8+ TCM) depends on fatty acid oxidation (FAO) to meet their metabolic requirements, which is regulated by adenosine monophosphate activated protein kinase (AMPK). In addition, the tumor microenvironment (TME) is severely immunosuppressive, conferring additional protection against the host immune response mediated by PTT. Methods Metformin (Met) down-regulates NADH/NADPH, promotes the FAO of CD8+ T cells by activating AMPK, increases the number of CD8+ TCM, which boosts the long-term immune memory of tumor-bearing mice treated with PTT. Here, a kind of PLGA microspheres co-encapsulated hollow gold nanoshells and Met (HAuNS-Met@MS) was constructed to inhibit the tumor progress. 2-Deoxyglucose (2DG), a glycolysis inhibitor for cancer starving therapy, can cause energy loss of tumor cells, reduce the heat stress response of tumor cell, and reverse its photothermal resistance. Moreover, 2DG prevents N-glycosylation of proteins that cause endoplasmic reticulum stress (ERS), further synergistically enhance PTT-induced tumor immunogenic cell death (ICD), and improve the effect of immunotherapy. So 2DG was also introduced and optimized here to solve the metabolic competition among tumor cells and immune cells in the TME. Results We utilized mild PTT effect of HAuNS to propose an in situ vaccine strategy based on the tumor itself. By targeting the metabolism of TME with different administration strategy of 2DG and perdurable action of Met, the thermotolerance of tumor cells was reversed, more CD8+ TCMs were produced and more effective anti-tumor was presented in this study. Conclusion The Step-by-Step starving-photothermal therapy could not only reverse the tumor thermotolerance, but also enhance the ICD and produce more CD8+ TCM during the treatment. Graphical Abstract

Multifunctional MoS2 nanosheets with Au NPs grown in situ for synergistic chemo-photothermal therapy

2019 ◽  
Vol 184 ◽  
pp. 110551 ◽  
Author(s):  
Maosheng Xu ◽  
Kunsong Zhang ◽  
Yubing Liu ◽  
Jie Wang ◽  
Ke Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Mos2 Nanosheets ◽  
Au Nps

Intelligent Hybrid Hydrogels for Rapid In Situ Detection and Photothermal Therapy of Bacterial Infection

2020 ◽  
Vol 12 (35) ◽  
pp. 39685-39694 ◽  
Author(s):  
Haoping Wang ◽  
Sirong Zhou ◽  
Lixia Guo ◽  
Yunxia Wang ◽  
Liheng Feng
Keyword(s):  
Bacterial Infection ◽  
Photothermal Therapy ◽  
Hybrid Hydrogels ◽  
In Situ Detection

scholarly journals Tumor Margin Demarcation and Therapy: A NanoFlare‐Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy (Small 50/2018)

Small ◽  
2018 ◽  
Vol 14 (50) ◽  
pp. 1870245
Author(s):  
Rong Yan ◽  
Jie Chen ◽  
Jianhao Wang ◽  
Jiaming Rao ◽  
Xuancheng Du ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Margin
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