PEGylated Indium Nanoparticles: A Metallic Contrast Agent for Multiwavelength Photoacoustic Imaging and Second Near-Infrared Photothermal Therapy

2021 ◽  
Author(s):  
Yu Chen ◽  
Haitao Wu ◽  
Hu Zhou ◽  
Zhaohua Miao ◽  
Fengqiu Hong ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Indium Nanoparticles

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Matias Luis Picchio ◽  
Julian Bergueiro Álvarez ◽  
Stefanie Wedepohl ◽  
Roque J Minari ◽  
Cecilia Ines Alvarez Igarzabal ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Hydrophobic Protein ◽  
Nir Dyes ◽  
Protein Pockets ◽  
J Aggregates ◽  
Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

scholarly journals Polypyrrole–methylene blue nanoparticles as a single multifunctional nanoplatform for near-infrared photo-induced therapy and photoacoustic imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35027-35037 ◽  
Author(s):  
Thi Tuong Vy Phan ◽  
Subramaniyan Bharathiraja ◽  
Van Tu Nguyen ◽  
Madhappan Santha Moorthy ◽  
Panchanathan Manivasagan ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Contrast Agent ◽  
Near Infrared ◽  
Photoacoustic Imaging

A novel contrast agent with broad NIR absorbing properties for combined photo-induced therapy and photoacoustic imaging.

scholarly journals Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

2020 ◽  
Vol 6 (33) ◽  
pp. eaba3546 ◽  
Author(s):  
Xuan Yi ◽  
Hailin Zhou ◽  
Yu Chao ◽  
Saisai Xiong ◽  
Jing Zhong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Immune Checkpoint Blockade ◽  
Immune Memory ◽  
Immunotherapy Of Cancer ◽  
Rapid Clearance ◽  
Inhibit Tumor Metastasis

We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Metallic 1T Phase Enabling MoS 2 Nanodots as an Efficient Agent for Photoacoustic Imaging Guided Photothermal Therapy in the Near‐Infrared‐II Window

Small ◽  
2020 ◽  
Vol 16 (43) ◽  
pp. 2004173 ◽  
Author(s):  
Zhan Zhou ◽  
Bowen Li ◽  
Chuang Shen ◽  
Di Wu ◽  
Huacheng Fan ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Theranostics of Gold Nanoparticles with an Emphasis on Photoacoustic Imaging and Photothermal Therapy

2018 ◽  
Vol 24 (23) ◽  
pp. 2719-2728 ◽  
Author(s):  
Yi Liu ◽  
Wenhui Ma ◽  
Jing Wang
Keyword(s):  
Gold Nanoparticles ◽  
Temperature Control ◽  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Chemical Characteristics ◽  
Nir Light ◽  
Physical And Chemical

Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends.

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