scholarly journals The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

2020 ◽  
Vol 12 (39) ◽  
pp. 43474-43487
Author(s):  
Lilianne Beola ◽  
Laura Asín ◽  
Catarina Roma-Rodrigues ◽  
Yilian Fernández-Afonso ◽  
Raluca M. Fratila ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
Apoptotic Death

scholarly journals Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

2017 ◽  
Vol 5 (36) ◽  
pp. 7644-7660 ◽  
Author(s):  
Chalani Mandawala ◽  
Imène Chebbi ◽  
Mickael Durand-Dubief ◽  
Raphael Le Fèvre ◽  
Yasmina Hamdous ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Oleic Acid ◽  
Magnetic Nanoparticles ◽  
Citric Acid ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
Carboxy Methyl

Magnetic hyperthermia in which magnetic nanoparticles are introduced into tumors and exposed to an alternating magnetic field, appears to be promising.

scholarly journals Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 438
Author(s):  
Felista L. Tansi ◽  
Filipp Fröbel ◽  
Wisdom O. Maduabuchi ◽  
Frank Steiniger ◽  
Martin Westermann ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Magnetic Nanoparticles ◽  
Tumor Stroma ◽  
Magnetic Hyperthermia ◽  
Magnetic Nanomaterials ◽  
Hyperthermia Treatment ◽  
Pancreatic Cancer Cells ◽  
Cancer Models

Magnetic hyperthermia can cause localized thermal eradication of several solid cancers. However, a localized and homogenous deposition of high concentrations of magnetic nanomaterials into the tumor stroma and tumor cells is mostly required. Poorly responsive cancers such as the pancreatic adenocarcinomas are hallmarked by a rigid stroma and poor perfusion to therapeutics and nanomaterials. Hence, approaches that enhance the infiltration of magnetic nanofluids into the tumor stroma convey potentials to improve thermal tumor therapy. We studied the influence of the matrix-modulating enzymes hyaluronidase and collagenase on the uptake of magnetic nanoparticles by pancreatic cancer cells and 3D spheroids thereof, and the overall impact on magnetic heating and cell death. Furthermore, we validated the effect of hyaluronidase on magnetic hyperthermia treatment of heterotopic pancreatic cancer models in mice. Treatment of cultured cells with the enzymes caused higher uptake of magnetic nanoparticles (MNP) as compared to nontreated cells. For example, hyaluronidase caused a 28% increase in iron deposits per cell. Consequently, the thermal doses (cumulative equivalent minutes at 43 °C, CEM43) increased by 15–23% as compared to heat dose achieved for cells treated with magnetic hyperthermia without using enzymes. Likewise, heat-induced cell death increased. In in vivo studies, hyaluronidase-enhanced infiltration and distribution of the nanoparticles in the tumors resulted in moderate heating levels (CEM43 of 128 min as compared to 479 min) and a slower, but persistent decrease in tumor volumes over time after treatment, as compared to comparable treatment without hyaluronidase. The results indicate that hyaluronidase, in particular, improves the infiltration of magnetic nanoparticles into pancreatic cancer models, impacts their thermal treatment and cell depletion, and hence, will contribute immensely in the fight against pancreatic and many other adenocarcinomas.

scholarly journals Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1203
Author(s):  
Hira Fatima ◽  
Tawatchai Charinpanitkul ◽  
Kyo-Seon Kim
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Hyperthermia Treatment ◽  
Coating Materials ◽  
Heating Efficiency ◽  
Hyperthermia Therapy ◽  
Corona Formation

The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

scholarly journals Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaser Hadadian ◽  
Ana Paula Ramos ◽  
Theo Z. Pavan
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Linear Response Theory ◽  
Magnetic Hyperthermia ◽  
Superior Performance ◽  
Dipolar Interactions ◽  
Intrinsic Properties ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

AbstractOptimizing the intrinsic properties of magnetic nanoparticles for magnetic hyperthermia is of considerable concern. In addition, the heating efficiency of the nanoparticles can be substantially influenced by dipolar interactions. Since adequate control of the intrinsic properties of magnetic nanoparticles is not straightforward, experimentally studying the complex interplay between these properties and dipolar interactions affecting the specific loss power can be challenging. Substituting zinc in magnetite structure is considered as an elegant approach to tune its properties. Here, we present experimental and numerical simulation results of magnetic hyperthermia studies using a series of zinc-substituted magnetite nanoparticles (ZnxFe1-xFe2O4, x = 0.0, 0.1, 0.2, 0.3 and 0.4). All experiments were conducted in linear regime and the results were inferred based on the numerical simulations conducted in the framework of the linear response theory. The results showed that depending on the nanoparticles intrinsic properties, interparticle interactions can have different effects on the specific loss power. When dipolar interactions were strong enough to affect the heating efficiency, the parameter σ = KeffV/kBT (Keff is the effective anisotropy and V the volume of the particles) determined the type of the effect. Finally, the sample x = 0.1 showed a superior performance with a relatively high intrinsic loss power 5.4 nHm2kg−1.

scholarly journals Biophysical Characterization of (Silica-coated) Cobalt Ferrite Nanoparticles for Hyperthermia Treatment

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1713 ◽  
Author(s):  
Niklas Lucht ◽  
Ralf P. Friedrich ◽  
Sebastian Draack ◽  
Christoph Alexiou ◽  
Thilo Viereck ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Particle System ◽  
Medical Condition ◽  
Low Cost ◽  
Heat Stroke ◽  
Magnetic Hyperthermia ◽  
Modern Medicine ◽  
The Body ◽  
Jurkat Cells ◽  
Hyperthermia Treatment

Magnetic hyperthermia is a technique that describes the heating of material through an external magnetic field. Classic hyperthermia is a medical condition where the human body overheats, being usually triggered by a heat stroke, which can lead to severe damage to organs and tissue due to the denaturation of cells. In modern medicine, hyperthermia can be deliberately induced to specified parts of the body to destroy malignant cells. Magnetic hyperthermia describes the way that this overheating is induced and it has the inherent advantage of being a minimal invasive method when compared to traditional surgery methods. This work presents a particle system that offers huge potential for hyperthermia treatments, given its good loss value, i.e., the particles dissipate a lot of heat to their surroundings when treated with an ac magnetic field. The measurements were performed in a low-cost custom hyperthermia setup. Additional toxicity assessments on Jurkat cells show a very low short-term toxicity on the particles and a moderate low toxicity after two days due to the prevalent health concerns towards nanoparticles in organisms.

Sign in / Sign up

Export Citation Format

Share Document