scholarly journals Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

2017 ◽  
Vol 5 (36) ◽  
pp. 7644-7660 ◽  
Author(s):  
Chalani Mandawala ◽  
Imène Chebbi ◽  
Mickael Durand-Dubief ◽  
Raphael Le Fèvre ◽  
Yasmina Hamdous ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Oleic Acid ◽  
Magnetic Nanoparticles ◽  
Citric Acid ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
Carboxy Methyl

Magnetic hyperthermia in which magnetic nanoparticles are introduced into tumors and exposed to an alternating magnetic field, appears to be promising.

scholarly journals Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1203
Author(s):  
Hira Fatima ◽  
Tawatchai Charinpanitkul ◽  
Kyo-Seon Kim
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Hyperthermia Treatment ◽  
Coating Materials ◽  
Heating Efficiency ◽  
Hyperthermia Therapy ◽  
Corona Formation

The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

scholarly journals Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3240
Author(s):  
Michael Zeinoun ◽  
Javier Domingo-Diez ◽  
Miguel Rodriguez-Garcia ◽  
Oscar Garcia ◽  
Miroslav Vasic ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Heat Production ◽  
Power Dissipation ◽  
Magnetic Hyperthermia ◽  
Experimental Results ◽  
Production Performance ◽  
Alternating Magnetic Field ◽  
In Vivo Studies ◽  
Sinusoidal Signals

For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal is its availability and the facility to produce it. Following the development of a configurable alternating magnetic field generator, we aim to study the effect of various waveforms on the heat production effectiveness of magnetic nanoparticles, seeking to prove that signals with more significant slope values, such as the trapezoidal and almost-square signals, allow the nanoparticles to reach higher efficiency in heat generation. Furthermore, we seek to point out that the nanoparticle power dissipation is dependent on the waveform’s slope and not only the frequency, magnetic field intensity and the nanoparticle size. The experimental results showed a remarkably higher heat production performance of the nanoparticles when exposed to trapezoidal and almost-square signals than conventional sinusoidal signals. We conclude that the nanoparticles respond better to the trapezoidal and almost-square signals. On the other hand, the experimental results were used to calculate the normalized power dissipation value and prove its dependency on the slope. However, adjustments are necessary to the coil before proceeding with in vitro and in vivo studies to handle the magnetic fields required.

scholarly journals Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1457 ◽  
Author(s):  
Huangtao Xu ◽  
Yongxin Pan
Keyword(s):  
Magnetic Field ◽  
Relaxation Time ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Core Size ◽  
Hyperthermia Treatment ◽  
Field Frequency ◽  
Glycerol Water ◽  
Heating Efficiency ◽  
Néel Relaxation

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (ΔT) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 °C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Néel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Néel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.

scholarly journals Iron Oxide Nanoparticles for Magnetic Hyperthermia

SPIN ◽  
2019 ◽  
Vol 09 (02) ◽  
pp. 1940001 ◽  
Author(s):  
N. A. Usov
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Stochastic Equation ◽  
Sharp Decrease ◽  
Dipole Interaction ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

Assemblies of magnetic nanoparticles show a great potential for application in biomedicine, particularly, magnetic hyperthermia. However, to achieve desired therapeutic effect in magnetic hyperthermia, the assembly of nanoparticles should have a sufficiently high specific absorption rate (SAR) in alternating magnetic field of moderate amplitude and frequency. Using the Landau–Lifshitz stochastic equation, it is shown that dilute assemblies of iron oxide nanoparticles of optimal diameters are capable of providing SAR of the order of 400–600[Formula: see text]W/g in alternating magnetic field with the amplitude [Formula: see text][Formula: see text]Oe in the frequency range f = 300–500[Formula: see text]kHz. Unfortunately, in dense clusters of magnetic nanoparticles, which are often formed in a biological medium, there is a sharp decrease in SAR due to the influence of strong magneto-dipole interaction of closest nanoparticles. To overcome this difficulty, it is suggested covering the nanoparticles with nonmagnetic shells of sufficient thickness or using non-single-domain nanoparticles being in magnetization curling states.

scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

Contribution of a 300 kHz alternating magnetic field on magnetic hyperthermia treatment of HepG2 cells

2012 ◽  
Vol 34 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Xiaowen Wang ◽  
Youping Chen ◽  
Changshuo Huang ◽  
Xufei Wang ◽  
Linyun Zhao ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Hepg2 Cells ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment

scholarly journals Transmittance measurements in non-alternating magnetic field as reliable method for determining of heating properties of Fe3O4 magnetic nanoparticles

2021 ◽  
Author(s):  
Magdalena Radović ◽  
Marija Mirković ◽  
Aleksandar S. Nikolić ◽  
Milorad Kuraica ◽  
Predrag Iskrenović ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Radiochemical Purity ◽  
Biomedical Application ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
High Heating ◽  
Theranostic Agents

Abstract Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe3O4 magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe3O4-MNPs were radiolabeled with radionuclide 177Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as sine qua non for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.

scholarly journals Magnetic Nanoparticles with High Specific Absorption Rate at Low Alternating Magnetic Field

Nano LIFE ◽  
2015 ◽  
Vol 05 (02) ◽  
pp. 1550002 ◽  
Author(s):  
K. Kekalo ◽  
I. Baker ◽  
R. Meyers ◽  
J. Shyong
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Absorption Rate ◽  
Specific Absorption Rate ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
Specific Absorption ◽  
New Type ◽  
Carboxymethyl Dextran

This paper describes the synthesis and properties of a new type of magnetic nanoparticle (MNP) for use in the hyperthermia treatment of tumors. These particles consist of 2–4 nm crystals of gamma- Fe 2 O 3 gathered in 20–40 nm aggregates with a coating of carboxymethyl-dextran, producing a zetasize of 110–120 nm. Despite their very low saturation magnetization (1.5–6.5 emu/g), the specific absorption rate (SAR) of the nanoparticles is 22–200 W/g at applied alternating magnetic field (AMF) with strengths of 100–500 Oe at a frequency of 160 kHz.

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