scholarly journals Magnetic Particle Imaging for Magnetic Hyperthermia Treatment: Visualization and Quantification of the Intratumoral Distribution and Temporal Change of Magnetic Nanoparticles <i>in Vivo</i>

2016 ◽  
Vol 06 (01) ◽  
pp. 1-15 ◽  
Author(s):  
Tomomi Kuboyabu ◽  
Isamu Yabata ◽  
Marina Aoki ◽  
Natsuo Banura ◽  
Kohei Nishimoto ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Particle ◽  
Temporal Change ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Intratumoral Distribution

scholarly journals Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications

Theranostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 2965-2981 ◽  
Author(s):  
Prashant Chandrasekharan ◽  
Zhi Wei Tay ◽  
Daniel Hensley ◽  
Xinyi Y Zhou ◽  
Barry KL Fung ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Magnetic Hyperthermia ◽  
Imaging Systems ◽  
Medical Applications ◽  
Hyperthermia Treatment ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy

ACS Nano ◽  
2018 ◽  
Vol 12 (4) ◽  
pp. 3699-3713 ◽  
Author(s):  
Zhi Wei Tay ◽  
Prashant Chandrasekharan ◽  
Andreina Chiu-Lam ◽  
Daniel W. Hensley ◽  
Rohan Dhavalikar ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Magnetic Hyperthermia ◽  
Magnetic Particle Imaging ◽  
Hyperthermia Therapy ◽  
Gradient Fields ◽  
Particle Imaging

scholarly journals Introducing a frequency-tunable magnetic particle spectrometer

2015 ◽  
Vol 1 (1) ◽  
pp. 249-253 ◽  
Author(s):  
André Behrends ◽  
Matthias Graeser ◽  
Thorsten M. Buzug
Keyword(s):  
Magnetic Nanoparticles ◽  
Image Quality ◽  
Magnetic Particle ◽  
Imaging Modality ◽  
Magnetic Particle Imaging ◽  
Common Technique ◽  
Frequency Tunable ◽  
Excitation Frequencies ◽  
Particle Imaging

AbstractImage quality in the new imaging modality magnetic particle imaging (MPI) heavily relies on the quality of the magnetic nanoparticles in use. Therefore, it is crucial to understand the behaviour of such particles. A common technique to analyze the behaviour of the particles is magnetic particle spectrometry (MPS). However, most spectrometers are limited to measurements at a single or multiple discrete excitation frequencies. This paper introduces a frequency-tunable spectrometer, able to perform measurements in the range of 100 Hz - 24kHz.

scholarly journals In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Azadeh Mohtashamdolatshahi ◽  
Harald Kratz ◽  
Olaf Kosch ◽  
Ralf Hauptmann ◽  
Nicola Stolzenburg ◽  
...  
Keyword(s):  
Image Quality ◽  
Inferior Vena Cava ◽  
Temporal Resolution ◽  
Magnetic Particle ◽  
Inferior Vena ◽  
Vena Cava ◽  
High Temporal Resolution ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Abstract Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may be suited for cardiovascular imaging. Its sensitivity and spatial resolution critically depend on the magnetic properties of MNP. Therefore, we used novel multicore nanoparticles (MCP 3) for in-vivo MPI in rats and analyzed dose requirements, sensitivity and detail resolution. 8 rats were examined using a preclinical MPI scanner (Bruker Biospin GmbH, Germany) equipped with a separate receive coil. MCP 3 and Resovist were administered intravenously (i.v.) into the rats’ tail veins at doses of 0.1, 0.05 and 0.025 mmol Fe/kg followed by serial MPI acquisition with a temporal resolution of 46 volumes per second. Based on a qualitative visual scoring system MCP 3–MPI images showed a significantly (P ≤ 0.05) higher image quality than Resovist-MPI images. Morphological features such as vessel lumen diameters (DL) of the inferior vena cava (IVC) and abdominal aorta (AA) could be assessed along a 2-cm segment in mesenteric area only after administration of MCP 3 at dosages of 0.1, 0.05 mmol Fe/kg. The mean DL ± SD estimated was 2.7 ± 0.6 mm for IVC and 2.4 ± 0.7 mm for AA. Evaluation of DL of the IVC and AA was not possible in Resovist-MPI images. Our results show, that MCP 3 provide better image quality at a lower dosage than Resovist. MCP 3-MPI with a clinically acceptable dose of 0.05 mmol Fe/kg increased the visibility of vessel lumens compared to Resovist-based MPI towards possible detection of vascular abnormalities such as stenosis or aneurysms, in vivo.

Optimization of Magnetic Nanoparticles for Magnetic Particle Imaging

2012 ◽  
Vol 48 (11) ◽  
pp. 3780-3783 ◽  
Author(s):  
Frank Ludwig ◽  
Thilo Wawrzik ◽  
Takashi Yoshida ◽  
Nicole Gehrke ◽  
Andreas Briel ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Particle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Dynamic Magnetic Properties of Optimized Magnetic Nanoparticles for Magnetic Particle Imaging

2014 ◽  
Vol 50 (11) ◽  
pp. 1-4 ◽  
Author(s):  
Frank Ludwig ◽  
Christian Kuhlmann ◽  
Thilo Wawrzik ◽  
Jan Dieckhoff ◽  
Aidin Lak ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Particle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging
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