pH-Responsive Charge-Conversional Poly(ethylene imine)–Poly(l-lysine)–Poly(l-glutamic acid) with Self-Assembly and Endosome Buffering Ability for Gene Delivery Systems

2018 ◽  
Vol 1 (5) ◽  
pp. 1496-1504 ◽  
Author(s):  
Kitae Ryu ◽  
Min Kyoung Lee ◽  
Jaehong Park ◽  
Tae-il Kim
Keyword(s):  
Gene Delivery ◽  
Glutamic Acid ◽  
Self Assembly ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Ethylene Imine ◽  
Poly Ethylene

Star Shaped Poly(ethylene glycols) Yield Biocompatible Gene Delivery Systems

2015 ◽  
Vol 2 (4) ◽  
pp. 182-195 ◽  
Author(s):  
Jayanant Iemsam-Arng ◽  
Xiao Kong ◽  
Andreas G. Schatzlein ◽  
Ijeoma F. Uchegbu
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Ethylene Glycols ◽  
Poly Ethylene

Integrin ανβ3Targeted Gene Delivery Using RGD Peptidomimetic Conjugates with Copolymers of PEGylated Poly(ethylene imine)

2009 ◽  
Vol 20 (6) ◽  
pp. 1270-1280 ◽  
Author(s):  
Olivia M. Merkel ◽  
Oliver Germershaus ◽  
Carol K. Wada ◽  
Peter J. Tarcha ◽  
Thomas Merdan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Poly Ethylene

Dextran-graft-linear poly(ethylene imine)s for gene delivery: Importance of the linking strategy

2014 ◽  
Vol 113 ◽  
pp. 597-606 ◽  
Author(s):  
Sofia Ochrimenko ◽  
Antje Vollrath ◽  
Lutz Tauhardt ◽  
Kristian Kempe ◽  
Stephanie Schubert ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Linear Poly ◽  
Poly Ethylene

Y-shaped block copolymer (methoxy-poly(ethylene glycol))2-b-poly(l-glutamic acid): preparation, self-assembly, and use as drug carriers

RSC Advances ◽  
2014 ◽  
Vol 4 (78) ◽  
pp. 41588-41596 ◽  
Author(s):  
Lixin Yang ◽  
Xiuli Hu ◽  
Weiqi Wang ◽  
Shi Liu ◽  
Tingting Sun ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Solid Tumors ◽  
Self Assembly ◽  
Drug Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Polymer Drugs

The nano polymer drugs based on Y-shaped block copolymer mPEG2-PGA show a great potential on the treatment for solid tumors.

The Synthesis of Cyclic Poly(ethylene imine) and Exact Linear Analogues: An Evaluation of Gene Delivery Comparing Polymer Architectures

2015 ◽  
Vol 137 (20) ◽  
pp. 6541-6549 ◽  
Author(s):  
Mallory A. Cortez ◽  
W T. Godbey ◽  
Yunlan Fang ◽  
Molly E. Payne ◽  
Brian J. Cafferty ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Imine ◽  
Polymer Architectures ◽  
Poly Ethylene

Synthesis and Self-Assembly of Well-Defined pH-Responsive Block Glycopolymers

2015 ◽  
Vol 815 ◽  
pp. 359-366 ◽  
Author(s):  
Qing Yun Yu ◽  
Lu Bin Lin ◽  
Xue Yu Xing ◽  
Hai Liang Dong ◽  
Xiao Ze Jiang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Phenylboronic Acid ◽  
Proton Nuclear Magnetic Resonance ◽  
Similar Degree ◽  
Random Structure ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Poly Ethylene

Two pH-responsive block glycopolymers, poly (ethylene glycol)-b-Poly (2- (diethylamino) ethyl methacrylate-co-2-gluconamidoethyl methacrylate) (PEG113-b-P(DEA55-co-GAMA12)) and poly (ethylene glycol)-b-poly (2-(diethylamino) ethyl methacrylate)-b-poly (2-gluconamido ethyl methacrylate) (PEG113-b-PDEA55-b-PGAMA15), were synthesized via atom transfer radical polymerization (ATRP) by directly or successively polymerization of GAMA and DEA monomers using a PEG-based macroinitiator, respectively, without protecting group chemistry. Those block glycopolymers were confirmed by proton Nuclear Magnetic Resonance (1H NMR) and Gel Permeation Chromatography (GPC), and their self-assembly behaviors were characterized by Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and Zeta-potential. The results show both synthetic block glycopolymers were dissolved molecularly in aqueous solution at acidic pH (such as pH 3), thus it can reversibly convert to be two-layer micelles comprising DEA and GAMA cores, PEG coronas with size of around 50 nm, or micelles comprising DEA cores, GAMA and PEG outer coronas with bigger size of 70 nm for PEG113-b- P(DEA55-co-GAMA12) and PEG113-b-PDEA55-b-PGAMA15), respectively, at basic condition. Both glycopolymers have the micellization process at middle pH (pH 6-8), but possess different isoelectric points (pIs) (at pH 8.0 and 7.8) for their pH responsive block of PEG113-b-P(DEA55-co-GAMA12) and PEG113-b-PDEA55-b-PGAMA15 with DEA-co-GAMA random structure or DEA chain only, respectively. This study not only reveals the self-assembly of pH responsive block glycopolymers with different architectures by fixing similar degree polymerization (DP) of their blocks, but also provides a tool to investigate pH induced dynamic covalent interaction between glycopolymers and phenylboronic acid derivatives or a light for designing novel drug delivery carriers.

Copolymer Nanoparticles Prepared by Self-Assembly of Poly(ethylene glycol) and Poly-γ-Glutamic Acid and its Characteristics

2013 ◽  
Vol 662 ◽  
pp. 136-139
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Poly Ethylene Glycol ◽  
Polyelectrolyte Complexes ◽  
Self Assembling ◽  
Transmission Electron ◽  
Poly Ethylene

The paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and poly(ethylene glycol) (PEG). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic lightscattering and transmission electron microscopy.It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and PEG solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 30–270 nm. measured by TEM, and the average hydrodynamic diameters were between 130 and 300 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

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