Recent Progress in Iron Oxide Nanoparticles as Therapeutic Magnetic Agents for Cancer Treatment and Tissue Engineering

2020 ◽  
Vol 3 (12) ◽  
pp. 8172-8187
Author(s):  
Mahboubeh Nabavinia ◽  
Juan Beltran-Huarac
Nanoscale ◽  
2015 ◽  
Vol 7 (29) ◽  
pp. 12728-12736 ◽  
Author(s):  
Christopher A. Quinto ◽  
Priya Mohindra ◽  
Sheng Tong ◽  
Gang Bao

Superparamagnetic iron oxide nanoparticles optimized with a phospholipid-PEG coating achieve high Doxorubicin loading and heat generation for an enhanced multimodal cancer treatment.


2017 ◽  
Vol Volume 12 ◽  
pp. 3207-3220 ◽  
Author(s):  
Johanna Poller ◽  
Jan Zaloga ◽  
Eveline Schreiber ◽  
Harald Unterweger ◽  
Christina Janko ◽  
...  

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3013
Author(s):  
Julian Palzer ◽  
Lea Eckstein ◽  
Ioana Slabu ◽  
Oliver Reisen ◽  
Ulf P. Neumann ◽  
...  

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.


Nanomaterials ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 426 ◽  
Author(s):  
Sudip Mondal ◽  
Panchanathan Manivasagan ◽  
Subramaniyan Bharathiraja ◽  
Madhappan Santha Moorthy ◽  
Van Nguyen ◽  
...  

Author(s):  
Kivilcim Buyukhatipoglu ◽  
Wei Sun ◽  
Alisa Morss Clyne

Tissue engineering may require precise patterning of cells and bioactive factors to recreate the complex, 3D architecture of native tissue. These cells and bioactive components may then need to be repositioned during tissue growth in vitro and noninvasively imaged to track tissue development. We developed a new hybrid nano-bioprinting system by combining the initial patterning capabilities of a direct cell writing system with the active patterning capabilities of superparamagnetic nanoparticles. The iron oxide nanoparticles can be conjugated with proteins or loaded inside cells, printed into computer-defined patterns, and then manipulated and imaged within the 3D tissue engineering construct. In this study, iron oxide nanoparticles were bioprinted either in an alginate scaffold or inside endothelial cells. Cell viability, patterning, and imaging were assessed.


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