PEGylated Dimeric BODIPY Photosensitizers as Nanocarriers for Combined Chemotherapy and Cathepsin B-Activated Photodynamic Therapy in 3D Tumor Spheroids

2020 ◽  
Vol 3 (6) ◽  
pp. 3835-3845 ◽  
Author(s):  
Sheng Lu ◽  
Xiang Lei ◽  
Hao Ren ◽  
Shiyue Zheng ◽  
Jian Qiang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cathepsin B ◽  
Combined Chemotherapy ◽  
Tumor Spheroids

Preparation of fluorescent mesoporous hollow silica–fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 11894-11898 ◽  
Author(s):  
Yannan Yang ◽  
Meihua Yu ◽  
Hao Song ◽  
Yue Wang ◽  
Chengzhong Yu
Keyword(s):  
Photodynamic Therapy ◽  
Selective Etching ◽  
Particle Sizes ◽  
Combined Chemotherapy ◽  
Excellent Performance ◽  
Hollow Silica ◽  
Fullerene Nanoparticles

Fluorescent mesoporous hollow silica–fullerene nanoparticles with particle sizes of ∼50 nm have been successfully prepared, showing excellent performance in combined chemo-photodynamic therapy.

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

2017 ◽  
Vol 53 (71) ◽  
pp. 9878-9881 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Yu Chen ◽  
Xingguo Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Tumor Spheroids ◽  
Two Photon ◽  
Metabolic Alteration ◽  
Targeted Photodynamic Therapy

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.

scholarly journals Photodynamic Therapy Using a Protease-Mediated Theranostic Agent Reduces Cathepsin-B Activity in Mouse Atheromata In Vivo

2013 ◽  
Vol 33 (6) ◽  
pp. 1360-1365 ◽  
Author(s):  
Soo-Min Shon ◽  
Yongdoo Choi ◽  
Jeong-Yeon Kim ◽  
Dong Kun Lee ◽  
Jin-Yong Park ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cathepsin B ◽  
Theranostic Agent

Abstract WP441: Photodynamic Therapy Using Protease-Mediated Theranostic Photodynamic Agent Reduces Cathepsin-B Activity in Mouse Carotid Atheromata In Vivo

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Soo-Min Shon ◽  
Yongdoo Choi ◽  
Dong Kun Lee ◽  
Jeong-Yeon Kim ◽  
Jin-Yong Park ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cathepsin B ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Continuous Wave ◽  
Knock Out ◽  
Theranostic Agent ◽  
Nirf Imaging ◽  
Bilateral Carotid

Background Carotid atherosclerosis is a major cause of ischemic stroke. Nanotechology-based theranostics for atherosclerosis and stroke is still in its infancy. Objective —To investigate if an intravenously-injected cathepsin-B activatable theranostic agent (L-SR15) would be cleaved in and release a fluorescent agent (chlorine-e6) in mouse carotid atheromata, allowing both the diagnostic visualization and therapeutic application of these fluorophores as photosensitizers during photodynamic therapy (PDT) to attenuate plaque-destabilizing cathepsin-B activity by selectively eliminating macrophages. Methods and Results Thirty-week-old Apolipoprotein-E knock-out mice received intravenous injection of L-SR15 theranostic agent (n=5), control agent D-SR16 (n=5), or PBS (n=5) three times at days 0, 7, and 14. Twenty-four hours after each injection, the bilateral carotid arteries were exposed and Cy5.5 near-infrared fluorescent (NIRF) imaging was performed. Fluorescent signal progressively accumulated in atheromata of the L-SR15 group animals only, indicating that photosensitizers had been released from the theranostic agent, and were accumulating in the plaque. After each imaging session, PDT was applied with a continuous-wave diode-laser. Additional Cy7 near infrared imaging with a CatB-sensing activatable NIRF imaging agent reduced CatB-realated signal only in the L-SR15, with activity at day 22 significantly lower than at baseline. Histological studies demonstrated that L-SR15-based PDT eliminated macrophages by inducing apoptosis without affecting plaque size or smooth muscle cell numbers. Conclusion This is the first study showing that macrophage-secreted cathepsin-B activity could be attenuated by PDT using a protease-mediated theranostic agent.

Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells

2012 ◽  
Vol 36 (9) ◽  
pp. 1179-1184 ◽  
Author(s):  
Berenice Diez ◽  
Glenda Ernst ◽  
María Julieta Teijo ◽  
Alcira Batlle ◽  
Silvia Hajos ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Combined Chemotherapy
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