scholarly journals pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release

2015 ◽  
Vol 7 (51) ◽  
pp. 28656-28664 ◽  
Author(s):  
Qing-Lan Li ◽  
Shi-Han Xu ◽  
Hang Zhou ◽  
Xin Wang ◽  
Biao Dong ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Mesoporous Silica Nanoparticles ◽  
Supramolecular Network ◽  
Dual Responsive

scholarly journals Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (37) ◽  
pp. 20862-20871 ◽  
Author(s):  
Chao Chen ◽  
Wen Sun ◽  
Wenji Yao ◽  
Yibing Wang ◽  
Hanjie Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Polymer Shell ◽  
Dual Responsive

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

Temperature-sensitive polypeptide brushes-coated mesoporous silica nanoparticles for dual-responsive drug release

2019 ◽  
Vol 30 (12) ◽  
pp. 2291-2294 ◽  
Author(s):  
Yahan Cui ◽  
Rong Deng ◽  
Xiangshuai Li ◽  
Xinghuo Wang ◽  
Qiong Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Temperature Sensitive ◽  
Dual Responsive

Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and delivery

Nanomedicine ◽  
2020 ◽  
Vol 15 (25) ◽  
pp. 2447-2458
Author(s):  
Xiaona Li ◽  
Shun Hu ◽  
Zhe Lin ◽  
Jie Yi ◽  
Xue Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Aldehyde Group ◽  
Real Time Monitoring ◽  
Dual Responsive

Aim: Smart mesoporous silica nanoparticles (MSNs) coated with carbon dots (CDs) and poly(N-vinylcaprolactam) (PNVCL) as a mixed shell (CDs/PNVCL polymer grafted MSNs) were prepared for pH-trigged anticancer drug release and real-time monitoring. Materials & methods: The amino-terminated PNVCL and amino-rich CDs were grafted onto the surface of aldehyde group functionalized MSNs through Schiff base reaction. Doxorubicin (DOX) was loaded into the prepared nanoparticles. Results: DOX could be quickly released in the tumor environment, leading to cell apoptosis. The linear fit between the percentage of released DOX and the fluorescence intensity of CDs indicated that the change in fluorescence intensity could be used to monitor drug release in real time. Conclusion: The as-prepared CDs/PNVCL polymer grafted MSNs are promising candidates for integrating controllable release and real-time monitoring in cancer treatment.

scholarly journals Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves

2010 ◽  
Vol 132 (36) ◽  
pp. 12690-12697 ◽  
Author(s):  
Huan Meng ◽  
Min Xue ◽  
Tian Xia ◽  
Yan-Li Zhao ◽  
Fuyuhiko Tamanoi ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (60) ◽  
pp. 34958-34962 ◽  
Author(s):  
Lu Zhou ◽  
Guojie Liu ◽  
Yang Wang ◽  
Jianling Liu ◽  
Yajie Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

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