Morphological Evolution of Strongly Fluorescent Water Soluble AIEEgen-Triblock Copolymer Mixed Aggregates with Shape-Dependent Cell Permeability

2020 ◽  
Vol 124 (45) ◽  
pp. 10282-10291 ◽  
Author(s):  
Soumyadipta Rakshit ◽  
Sharmistha Das ◽  
Vinodhini Govindaraj ◽  
Ratika Maini ◽  
Anil Kumar ◽  
...  
Nanoscale ◽  
2017 ◽  
Vol 9 (48) ◽  
pp. 19191-19200 ◽  
Author(s):  
Jinglin Shen ◽  
Zhi Wang ◽  
Di Sun ◽  
Guokui Liu ◽  
Shiling Yuan ◽  
...  

Supramolecular self-assembly, based on non-covalent interactions, has been employed as an efficient approach to obtain various functional materials from nanometer-sized building blocks, in particular, [Ag6(mna)6]6−, mna = mercaptonicotinate (Ag6-NC).


RSC Advances ◽  
2016 ◽  
Vol 6 (60) ◽  
pp. 55374-55381 ◽  
Author(s):  
Peter Černoch ◽  
Zulfiya Černochová ◽  
Svetlana Petrova ◽  
Dana Kaňková ◽  
Joon-Sung Kim ◽  
...  

Water-soluble PNaSS-b-PVDF-b-PNaSS triblock copolymer.


Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 159 ◽  
Author(s):  
Elena Giuliano ◽  
Donatella Paolino ◽  
Massimo Fresta ◽  
Donato Cosco

Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.


RSC Advances ◽  
2014 ◽  
Vol 4 (53) ◽  
pp. 27922-27930 ◽  
Author(s):  
Julia Elistratova ◽  
Maxim Mikhailov ◽  
Vladimir Burilov ◽  
Vasily Babaev ◽  
Ildar Rizvanov ◽  
...  

Water soluble hexanuclear molybdenum cluster assembled with triblock copolymer gives luminescent response on ion-pairing with difloxacin through energy transfer.


2019 ◽  
Vol 120 ◽  
pp. 415-424 ◽  
Author(s):  
I.E. Ojeda-Serna ◽  
N.E. Rocha-Guzmán ◽  
J.A. Gallegos-Infante ◽  
M.H. Cháirez-Ramírez ◽  
W. Rosas-Flores ◽  
...  

2020 ◽  
Vol 11 (21) ◽  
pp. 3615-3626
Author(s):  
Quan Zhou ◽  
Qi Liu ◽  
Yueru Yu ◽  
Yuxiao Zhuang ◽  
Yizhe Lv ◽  
...  

A epoxy-reactive poly(3,4-epoxycyclohexylmethyl methacrylate)-block-poly(dimethylsiloxane)-block-poly(3,4-epoxycyclohexylmethyl methacrylate) (PMETHB-b-PDMS-b-PMETHB) triblock can self-assemble in epoxy resin to form “anchor-chain” nanodomains.


1998 ◽  
Vol 550 ◽  
Author(s):  
W. A. Petka ◽  
J. L. Harden ◽  
J. K. Sakata ◽  
D. A. Tirrell

AbstractRecombinant DNA methods were used to create a new class of artificial proteins that undergo reversible gelation in response to changes in pH or temperature. These proteins consist of terminal a-helical “leucine zipper” domains flanking a central, water-soluble polvelectrolyte segment. The formation of coiled-coil aggregates of the terminal domains in near-neutral pH solution triggers formation of a polymer hydrogel, with the central polyelectrolyte segment retaining solvent and preventing precipitation of the chains. Dissociation of the coiled-coil aggregates through elevation of pH or temperature causes dissolution of the gel and a return to the viscous behavior characteristic of a polymer solution. The pH and temperature range of the hydrogel state and its viscoelastic properties may be systematically varied through precise changes of the length, composition and charge density of the terminal and central blocks. Such control is of value in designing hydrogels with predetermined physical properties and makes these biosynthetic triblock copolymer systems attractive candidates for use in molecular and cellular encapsulation and in controlled reagent delivery.


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