Fabrication of Two Types of Shell-Cross-Linked Micelles with “Inverted” Structures in Aqueous Solution from Schizophrenic Water-Soluble ABC Triblock Copolymer via Click Chemistry

Langmuir ◽  
2009 ◽  
Vol 25 (4) ◽  
pp. 2046-2054 ◽  
Author(s):  
Xiaoze Jiang ◽  
Guoying Zhang ◽  
Ravin Narain ◽  
Shiyong Liu
Keyword(s):  
Aqueous Solution ◽  
Click Chemistry ◽  
Triblock Copolymer ◽  
Water Soluble ◽  
Abc Triblock Copolymer

Bioconjugatable synthetic chlorins rendered water-soluble with three PEG-12 groups via click chemistry

2020 ◽  
Vol 24 (01n03) ◽  
pp. 362-378 ◽  
Author(s):  
Nobuyuki Matsumoto ◽  
Masahiko Taniguchi ◽  
Jonathan S. Lindsey
Keyword(s):  
Aqueous Solution ◽  
Quantum Yield ◽  
Click Chemistry ◽  
Fluorescence Quantum Yield ◽  
Molecular Design ◽  
Water Soluble ◽  
Propanoic Acid ◽  
Free Base ◽  
Yield Formula ◽  
Water Solubilization

Chlorins provide many ideal features for use as red-region fluorophores but require molecular tailoring for solubilization in aqueous solution. A chlorin building-block bearing 18,18-dimethyl, 15-bromo and 10-[2,4,6-tris(propargyloxy)phenyl] substituents has been transformed via click chemistry with CH3(OCH2CH[Formula: see text]-N3 followed by Suzuki coupling with 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, thereby installing a water-solubilization motif and a bioconjugatable handle, respectively. In toluene, [Formula: see text]-dimethylformamide (DMF) or water, the resulting facially encumbered free base chlorin exhibits characteristic chlorin absorption ([Formula: see text] [Formula: see text]412, 643 nm) and fluorescence ([Formula: see text] [Formula: see text]645 nm) spectra with only modest variation in fluorescence quantum yield ([Formula: see text] values (0.24, 0.25 and 0.19, respectively). The zinc chlorin derived therefrom exhibits similar spectral constancy ([Formula: see text] [Formula: see text]414 and 613 nm, [Formula: see text] [Formula: see text]616 nm) and [Formula: see text] 0.094, 0.10 and 0.086 in the three solvents. The results together indicate the viability of the molecular design and synthetic methodology to create red-region fluorophores for use in diverse applications.

scholarly journals Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

2018 ◽  
Vol 9 (6) ◽  
pp. 1454-1463 ◽  
Author(s):  
C. J. Mable ◽  
L. A. Fielding ◽  
M. J. Derry ◽  
O. O. Mykhaylyk ◽  
P. Chambon ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Diblock Copolymer ◽  
Triblock Copolymer ◽  
Ph Responsive ◽  
Emulsion Polymerisation ◽  
Abc Triblock Copolymer

A series of framboidal ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation and their acid-induced dissociation was characterised by SAXS.

Diverse nanostructures and gel behaviours contained in a thermo- and dual-pH-sensitive ABC (PNIPAM–PAA–P4VP) terpolymer in an aqueous solution

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88306-88314 ◽  
Author(s):  
Ping Yong ◽  
Yuejiao Yang ◽  
Zhiyong Wang ◽  
Liming Yang ◽  
Jie Chen
Keyword(s):  
Aqueous Solution ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Ph Sensitive ◽  
Reversible Addition ◽  
Subsequent Hydrolysis ◽  
Abc Triblock Copolymer

PNIPAM-b-PAA-b-P4VP (NAV), a thermo- and dual-pH-sensitive ABC triblock copolymer, was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent hydrolysis.

Light-mediated one-pot synthesis of an ABC triblock copolymer in aqueous solution via RAFT and the effect of pH on copolymer self-assembly

2018 ◽  
Vol 9 (29) ◽  
pp. 4000-4006 ◽  
Author(s):  
Sudhina Guragain ◽  
Juan Perez-Mercader
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
One Pot ◽  
Effect Of Ph ◽  
One Pot Synthesis ◽  
Abc Triblock Copolymer

We present the triblock copolymer self-assembly resulting into different morphologies that occurred during the polymerization of a hydrophobic third block in aqueous solution.

Enantioselective Recognition of Chiral Guests by the Water-Soluble Chiral Keplerate {Mo132} Spherical Capsule with 30 Inner Lactate Ligands

2019 ◽  
Author(s):  
Nancy Watfa ◽  
Weimin Xuan ◽  
Zoe Sinclair ◽  
Robert Pow ◽  
Yousef Abul-Haija ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Chiral Recognition ◽  
Association Constants ◽  
Water Soluble ◽  
Enantioselective Recognition ◽  
H Nmr ◽  
Dosy Nmr ◽  
Spherical Capsule ◽  
Surface Pores ◽  
Guest Chemistry

Investigations of chiral host guest chemistry are important to explore recognition in confined environments. Here, by synthesizing water-soluble chiral porous nanocapsule based on the inorganic metal-oxo Keplerate-type cluster, {Mo<sub>132</sub>} with chiral lactate ligands with the composition [Mo<sub>132</sub>O<sub>372</sub>(H<sub>2</sub>O)<sub>72</sub>(<i>x-</i>Lactate)<sub>30</sub>]<sup>42-</sup> (<i>x</i> = D or L), it was possible to study the interaction with a chiral guest, L/D-carnitine and (<i>R</i>/<i>S</i>)-2-butanol in aqueous solution. The enantioselective recognition was studied by quantitative <sup>1</sup>H NMR and <sup>1</sup>H DOSY NMR which highlighted that the chiral recognition is regulated by two distinct sites. Differences in the association constants (K) of L- and D-carnitine, which, due to their charge, are generally restricted from entering the interior of the host, are observed, indicating that their recognition predominantly occurs at the surface pores of the structure. Conversely, a larger difference in association constants (K<i><sub>S</sub></i>/K<i><sub>R</sub></i> = 3) is observed for recognition within the capsule interior of (<i>R</i>)- and (<i>S</i>)-2-butanol.

scholarly journals Sulfobetaine Cryogels for Preferential Adsorption of Methyl Orange from Mixed Dye Solutions

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 208
Author(s):  
Ramona B. J. Ihlenburg ◽  
Anne-Catherine Lehnen ◽  
Joachim Koetz ◽  
Andreas Taubert
Keyword(s):  
Aqueous Solution ◽  
Methylene Blue ◽  
Methyl Orange ◽  
Dye Removal ◽  
Selective Adsorption ◽  
Water Soluble ◽  
Organic Substances ◽  
Preferential Adsorption ◽  
Dimethyl Ammonium ◽  
Dye Solutions

New cryogels for selective dye removal from aqueous solution were prepared by free radical polymerization from the highly water-soluble crosslinker N,N,N’,N’-tetramethyl-N,N’-bis(2-ethylmethacrylate)-propyl-1,3-diammonium dibromide and the sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate. The resulting white and opaque cryogels have micrometer sized pores with a smaller substructure. They adsorb methyl orange (MO) but not methylene blue (MB) from aqueous solution. Mixtures of MO and MB can be separated through selective adsorption of the MO to the cryogels while the MB remains in solution. The resulting cryogels are thus candidates for the removal of hazardous organic substances, as exemplified by MO and MB, from water. Clearly, it is possible that the cryogels are also potentially interesting for removal of other compounds such as pharmaceuticals or pesticides, but this must be investigated further.

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