The Vagabond Fluorine Atom: Dissociative Photoionization of trans-1,3,3,3-Tetrafluoropropene

2020 ◽  
Vol 124 (19) ◽  
pp. 3738-3746
Author(s):  
Amelia W. Ray ◽  
Peter Weidner ◽  
Andras Bodi ◽  
Bálint Sztáray
Keyword(s):  
Fluorine Atom ◽  
Dissociative Photoionization

scholarly journals Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianke Su ◽  
Xinyuan Hu ◽  
Hua Huang ◽  
Yu Guo ◽  
Qiuling Song
Keyword(s):  
Fluorine Atom ◽  
High Efficiency ◽  
Addition Reaction ◽  
Bond Cleavage ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
General Strategy ◽  
Michael Addition Reaction ◽  
Fundamental Properties ◽  
Synthetic Approaches

Abstract2-Fluoroindoles as an important structural scaffold are widely existing in many bioactive or therapeutic agents. Despite their potential usefulness, efficient constructions of 2-fluoroindole derivatives are very sparce. The development of straightforward synthetic approaches to access 2-fluoroindoles is highly desirable for studying their fundamental properties and applications. Herein, we report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity. Instead of starting from indole skeletons, our strategy constructs indole scaffolds alongside the incorporation of fluorine atom on C2 position in a formal [4+1] cyclization from readily accessible ortho-vinylanilines and difluorocarbene. In our protocol, commercially accessible halodifluoroalkylative reagents provide one carbon and one fluorine atom by cleaving one C-N tertiary bond and forming one C-N bond and one C-C double bond with ortho-vinylanilines. Downstream transformations on 2-fluoroindoles lead to various valuable bioactive molecules which demonstrated significant synthetic advantages over previous reports. And mechanistic studies suggest that the reaction undergoes a cascade difluorocarbene-trapping and intramolecular Michael addition reaction followed by Csp3-F bond cleavage.

Ionization yields, total absorption, and dissociative photoionization cross sections of CH4 from 110 to 950 Å

1989 ◽  
Vol 90 (12) ◽  
pp. 6925-6932 ◽  
Author(s):  
James A. R. Samson ◽  
G. N. Haddad ◽  
T. Masuoka ◽  
P. N. Pareek ◽  
D. A. L. Kilcoyne
Keyword(s):  
Cross Sections ◽  
Total Absorption ◽  
Dissociative Photoionization

scholarly journals Design and Synthesis of Fluoro Analogues of Vitamin D

2021 ◽  
Vol 22 (15) ◽  
pp. 8191
Author(s):  
Fumihiro Kawagoe ◽  
Sayuri Mototani ◽  
Atsushi Kittaka
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Fluorine Atom ◽  
Chemical Properties ◽  
Molecular Structures ◽  
Physical And Chemical Properties ◽  
Design And Synthesis ◽  
Synthetic Methodologies ◽  
Physical And Chemical ◽  
And Chemical Properties

The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegative fluorine atom(s) into vitamin D3 skeletons alters their physical and chemical properties. To date, many fluorinated vitamin D3 analogues have been designed and synthesized. This review summarizes the molecular structures of fluoro-containing vitamin D3 analogues and their synthetic methodologies.

scholarly journals Planar Tetracoordinate Fluorine Atoms

2021 ◽  
Author(s):  
Gabriela Castillo-Toraya ◽  
Mesias Orozco-Ic ◽  
Eugenia Dzib ◽  
Ximena Zarate ◽  
Filiberto Ortiz-Chi ◽  
...  
Keyword(s):  
Fluorine Atom

Unlike other atoms, a planar tetracoordinate fluorine atom is elusive. So far, there are no theoretical or experimental reports suggesting their existence. Herein, we introduce the first six combinations (FIn4+,...

Stereoselective Synthesis of Insect Sex Pheromone Analogues Having a Fluorine Atom on Their Double Bonds.

ChemInform ◽  
2005 ◽  
Vol 36 (50) ◽  
Author(s):  
Tong Guan ◽  
Masanori Yoshida ◽  
Daisuke Ota ◽  
Tsuyoshi Fukuhara ◽  
Shoji Hara
Keyword(s):  
Sex Pheromone ◽  
Fluorine Atom ◽  
Stereoselective Synthesis ◽  
Double Bonds ◽  
Insect Sex Pheromone ◽  
Insect Sex
Sign in / Sign up

Export Citation Format

Share Document