Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids

2018 ◽  
Vol 83 (12) ◽  
pp. 6524-6533 ◽  
Author(s):  
Xiaonan Shi ◽  
Xi Chen ◽  
Muhua Wang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis ◽  
Cyclic Amines ◽  
Arylacetic Acids

Regioselective synthesis of spiro isoxazole‐oxindole‐tetrahydrothiophene hybrids via cascade reactions under catalyst‐free conditions

2019 ◽  
Vol 57 (1) ◽  
pp. 469-476 ◽  
Author(s):  
Sakkani Nagaraju ◽  
Kota Sathish ◽  
Neeli Satyanarayana ◽  
Banoth Paplal ◽  
Dhurke Kashinath
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis ◽  
Catalyst Free

Selective synthesis of β-nitrated N-heterocycles and N-nitroso-2-alkoxyamine aldehydes from inactivated cyclic amines promoted by tBuONO and oxoammonium salt

2019 ◽  
Vol 55 (82) ◽  
pp. 12372-12375 ◽  
Author(s):  
Yan He ◽  
Zhi Zheng ◽  
Yajie Liu ◽  
Jiajie Qiao ◽  
Xinying Zhang ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Selective Synthesis ◽  
Cyclic Amines ◽  
Oxoammonium Salt

Solvent-dependent-controlled selective synthesis of β-nitrated N-heterocycles and N-nitroso chain 2-alkoxyamine aldehydes has been successfully realized viatBuONO and oxoammonium salt promoted cascade reactions of inactivated cyclic amines.

C(sp3)–H dehydrogenation and C(sp2)–H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

2017 ◽  
Vol 53 (28) ◽  
pp. 4002-4005 ◽  
Author(s):  
Yan He ◽  
Fang Wang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cyclic Amines

A novel and efficient synthesis of tetrahydropyridine-, dihydropyrrole-, and tetrahydroazepine-3-carboxylates via cascade reactions of cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first example in which functionalized N-heterocycles were prepared through Pd-catalyzed C(sp3)–H dehydrogenation and C(sp2)–H carbonylation of cyclic amines.

Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides

2020 ◽  
Vol 18 (31) ◽  
pp. 6162-6170
Author(s):  
Tianzi Dai ◽  
Chen Cui ◽  
Xueyu Qi ◽  
Yanshu Cheng ◽  
Qian He ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Environmentally Benign

An efficient and regioselective strategy to synthesize substituted thiazoles via a cascade reaction in an environmentally benign medium was developed.

Cascade Reactions Utilizing the Nucleophilic Properties of 1,1‐Enediamines for the Regioselective Synthesis of 4‐Aryl‐2‐aminopyridines

2019 ◽  
Vol 4 (11) ◽  
pp. 3083-3087
Author(s):  
Ling‐Bin Kong ◽  
Sheng‐Jiao Yan ◽  
Yuan Yao ◽  
Qiang Xiao ◽  
Jun Lin
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis

Multi-component solvent-free cascade reaction of 2-cyanoacetamides: regioselective synthesis of pyridin-2-ones bearing quaternary centers

2020 ◽  
Vol 22 (1) ◽  
pp. 256-264 ◽  
Author(s):  
Lingbin Kong ◽  
Rong Huang ◽  
Haodan He ◽  
Yunxiang Fan ◽  
Jun Lin ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Solvent Free ◽  
Regioselective Synthesis ◽  
Quaternary Centers

A novel protocol has been constructed for the synthesis of four types of pyridin-2-ones via multicomponent solvent-free cascade reactions of 2-cyanoacetamides, various ketones, and acetone.

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