Regioselective Synthesis of 2-Alkenylindoles and 2-Alkenylindole-3-carboxylates through the Cascade Reactions of N-Nitrosoanilines with Propargyl Alcohols

2018 ◽  
Vol 83 (15) ◽  
pp. 8509-8521 ◽  
Author(s):  
Xia Song ◽  
Cai Gao ◽  
Bin Li ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis ◽  
Propargyl Alcohols

Regioselective synthesis of spiro isoxazole‐oxindole‐tetrahydrothiophene hybrids via cascade reactions under catalyst‐free conditions

2019 ◽  
Vol 57 (1) ◽  
pp. 469-476 ◽  
Author(s):  
Sakkani Nagaraju ◽  
Kota Sathish ◽  
Neeli Satyanarayana ◽  
Banoth Paplal ◽  
Dhurke Kashinath
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis ◽  
Catalyst Free

Complex Polycycles from Simple Propargyl Alcohols through Ruthenium-Catalyzed Cascade Reactions and One-Pot Procedures

Synthesis ◽  
2017 ◽  
Vol 50 (04) ◽  
pp. 742-752 ◽  
Author(s):  
Elisabeth Jäckel ◽  
Julia Kaufmann ◽  
Edgar Haak
Keyword(s):  
Drug Discovery ◽  
Organic Synthesis ◽  
High Selectivity ◽  
Multiple Bond ◽  
Cascade Reactions ◽  
Kb Cells ◽  
One Pot ◽  
Bond Forming ◽  
Common Precursor ◽  
Propargyl Alcohols

Multiple bond-forming cascade transformations and one-pot procedures are valuable tools in organic synthesis and drug discovery. These atom-economical processes provide rapid access to natural product-like scaffolds from simple precursors. Herein, we report on ruthenium-catalyzed one-pot conversions of simple 1-alkenyl propargyl alcohols with cyclic 3-ketolactones and dienophiles. Thereby, structurally diverse fused polycycles and functionalized bicyclic structures are accessible from a common precursor with high selectivity. Some of the new drug-like molecules exhibit cytotoxic activity against KB cells.

Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides

2020 ◽  
Vol 18 (31) ◽  
pp. 6162-6170
Author(s):  
Tianzi Dai ◽  
Chen Cui ◽  
Xueyu Qi ◽  
Yanshu Cheng ◽  
Qian He ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Environmentally Benign

An efficient and regioselective strategy to synthesize substituted thiazoles via a cascade reaction in an environmentally benign medium was developed.

Synthesis of Tetracyclic Indenopyrazolopyrazolones through Cascade Reactions of Aryl Azomethine Imines with Propargyl Alcohols

2021 ◽  
Author(s):  
Linghua Zhang ◽  
Jie Zhao ◽  
Yuqin Jiang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Azomethine Imines ◽  
Propargyl Alcohols

Presented herein is a novel and efficient synthesis of the synthetically and biologically attractive tetracyclic indenopyrazolopyrazolone derivatives through the cascade reactions of aryl azomethine imines with propargyl alcohols. Mechanistically, the...

Cascade Reactions Utilizing the Nucleophilic Properties of 1,1‐Enediamines for the Regioselective Synthesis of 4‐Aryl‐2‐aminopyridines

2019 ◽  
Vol 4 (11) ◽  
pp. 3083-3087
Author(s):  
Ling‐Bin Kong ◽  
Sheng‐Jiao Yan ◽  
Yuan Yao ◽  
Qiang Xiao ◽  
Jun Lin
Keyword(s):  
Cascade Reactions ◽  
Regioselective Synthesis
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