Sea Spray Aerosols Contain the Major Component of Human Lung Surfactant

2021 ◽  
Author(s):  
Emmanuel Van Acker ◽  
Maarten De Rijcke ◽  
Zixia Liu ◽  
Jana Asselman ◽  
Karel A.C. De Schamphelaere ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Surfactant ◽  
Sea Spray

Development of a human lung surfactant, derived from extracted amniotic fluid

1991 ◽  
Vol 1086 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Geertrui C.M. Gorree ◽  
Johannes Egberts ◽  
Gerard C.H. Bakker ◽  
Anneke Beintema ◽  
Margriet A. Top
Keyword(s):  
Amniotic Fluid ◽  
Human Lung ◽  
Lung Surfactant

The proteins of human lung surfactant

1985 ◽  
Vol 837 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Anthony D. Postle ◽  
Alan N. Hunt ◽  
I.Colin S. Normand
Keyword(s):  
Human Lung ◽  
Lung Surfactant

Molecular Structure of the Extracellular Surface Layer of the Human Lung Surfactant

2015 ◽  
pp. 176-180 ◽  
Author(s):  
Erna Ladanyi ◽  
I. R. Miller ◽  
Ronit Popovits-Biro ◽  
Y. Marikovsky ◽  
P. von Wichert ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Surface Layer ◽  
Human Lung ◽  
Lung Surfactant

Fine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavage

2007 ◽  
Vol 293 (4) ◽  
pp. L1053-L1058 ◽  
Author(s):  
Michaela Kendall
Keyword(s):  
Amino Acids ◽  
Fine Particles ◽  
Human Lung ◽  
Lung Surfactant ◽  
Statistical Technique ◽  
Lung Lavage ◽  
Chemical Components ◽  
Isoleucine Leucine ◽  
Analysis Technique ◽  
Lung Lining Fluid

Components of surfactant act as opsonins and enhance phagocytosis of bacteria; whether this process occurs with atmospheric fine particles has not been shown. We have studied the interactions of fine particles (urban PM2.5) and surfactant removed from normal human lungs by lavage, using a surface analysis technique. The aim was to identify which of the chemical components of brochoalveolar lavage (BAL) deposit on the surfaces of urban PM2.5. Deposition of surfactant components on urban PM2.5 surfaces was reported in previous studies, but molecular identification and relative quantification was not possible using simple data analysis. In this study, we were able to identify adsorbed components by applying an appropriate statistical technique, factor analysis. In this study, the most strongly associated mass fragment on PM2.5 surfaces exposed to BAL (and undetected on both untreated samples and saline controls) was di-palmitoyl-phosphatidylcholine, a component of lung surfactant. Amino acids were also strongly associated with BAL-exposed PM2.5 surfaces and not other sample types. Thirteen mass fragments were identified, diagnostic of the amino acids alanine, arginine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, serine, and valine. This study provides evidence that lung surfactant and amino acids related to opsonin proteins adsorb to nonbiological particle surfaces exposed to human lung lining fluid. Disruption of normal surfactant function, both physical and immunological, is possible but unproven. Further work on this PM-opsonin interaction is recommended.

Biochemical composition of adult human lung surfactant

Lung ◽  
1982 ◽  
Vol 160 (1) ◽  
pp. 195-206 ◽  
Author(s):  
S. A. Shelley ◽  
J. U. Balis ◽  
J. E. Paciga ◽  
C. G. Espinoza ◽  
A. V. Richman
Keyword(s):  
Biochemical Composition ◽  
Human Lung ◽  
Lung Surfactant ◽  
Adult Human ◽  
Adult Human Lung

scholarly journals Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

2010 ◽  
Vol 1 (6) ◽  
pp. 563-572 ◽  
Author(s):  
Anne Jäkel ◽  
Howard Clark ◽  
Kenneth B. M. Reid ◽  
Robert B. Sim
Keyword(s):  
Human Lung ◽  
Lung Surfactant ◽  
Surfactant Proteins
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