Molecular Structure of the Extracellular Surface Layer of the Human Lung Surfactant

2015 ◽  
pp. 176-180 ◽  
Author(s):  
Erna Ladanyi ◽  
I. R. Miller ◽  
Ronit Popovits-Biro ◽  
Y. Marikovsky ◽  
P. von Wichert ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Surface Layer ◽  
Human Lung ◽  
Lung Surfactant

Development of a human lung surfactant, derived from extracted amniotic fluid

1991 ◽  
Vol 1086 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Geertrui C.M. Gorree ◽  
Johannes Egberts ◽  
Gerard C.H. Bakker ◽  
Anneke Beintema ◽  
Margriet A. Top
Keyword(s):  
Amniotic Fluid ◽  
Human Lung ◽  
Lung Surfactant

The proteins of human lung surfactant

1985 ◽  
Vol 837 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Anthony D. Postle ◽  
Alan N. Hunt ◽  
I.Colin S. Normand
Keyword(s):  
Human Lung ◽  
Lung Surfactant

Sea Spray Aerosols Contain the Major Component of Human Lung Surfactant

2021 ◽  
Author(s):  
Emmanuel Van Acker ◽  
Maarten De Rijcke ◽  
Zixia Liu ◽  
Jana Asselman ◽  
Karel A.C. De Schamphelaere ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Surfactant ◽  
Sea Spray

Synthesis of a Carbosilane Dendrimer with Fluorocarbon Substituents at the Silicon Atoms in the Surface Layer of the Molecular Structure

2005 ◽  
Vol 403 (4-6) ◽  
pp. 155-159 ◽  
Author(s):  
N. A. Shumilkina ◽  
V. D. Myakushev ◽  
E. A. Tatarinova ◽  
M. O. Gallyamov ◽  
A. R. Khokhlov ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Surface Layer ◽  
Carbosilane Dendrimer

scholarly journals Studying penetrating ability of alkaline flow solution of caprolactam production in flint aggregate

2018 ◽  
Vol 196 ◽  
pp. 04016
Author(s):  
Natalia Chumachenko ◽  
Diana Kizilova ◽  
Ilnur Hafizov
Keyword(s):  
Molecular Structure ◽  
Surface Layer ◽  
Alkaline Solution ◽  
Solution Concentration ◽  
Processing Conditions ◽  
Duration Of Treatment ◽  
Processing Mode ◽  
Flow Solution ◽  
Optimal Processing ◽  
Siliceous Rock

The study focuses on increasing the clinker formation degree of calculus types of siliceous rock. One of the ways to increase the flint aggregate strength is to saturate the surface layer of grains with alkaline ions. While calcining, this will provide formation of confining elements which are more caked than the inner layers. To preserve natural porosity inside granules and to increase density and durability of a surface layer, it is offered to process grains of dense siliceous rock before calcining them with a solution of alkaline flow of caprolactam production (AFCP). It is shown that the degree of density is determined by the soaking depth, which depends on the molecular structure of alkaline solution. The paper also demonstrates results of influence of processing conditions on soaking depth of grains with 10-15 mm fraction. The researchers studied the effect of AFCP solution concentration in the range varying from 3 to 20%. The duration of treatment ranged from 2 to 5 minutes. The research results are presented in the form of graphs. The optimal processing mode is also determined.

Fine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavage

2007 ◽  
Vol 293 (4) ◽  
pp. L1053-L1058 ◽  
Author(s):  
Michaela Kendall
Keyword(s):  
Amino Acids ◽  
Fine Particles ◽  
Human Lung ◽  
Lung Surfactant ◽  
Statistical Technique ◽  
Lung Lavage ◽  
Chemical Components ◽  
Isoleucine Leucine ◽  
Analysis Technique ◽  
Lung Lining Fluid

Components of surfactant act as opsonins and enhance phagocytosis of bacteria; whether this process occurs with atmospheric fine particles has not been shown. We have studied the interactions of fine particles (urban PM2.5) and surfactant removed from normal human lungs by lavage, using a surface analysis technique. The aim was to identify which of the chemical components of brochoalveolar lavage (BAL) deposit on the surfaces of urban PM2.5. Deposition of surfactant components on urban PM2.5 surfaces was reported in previous studies, but molecular identification and relative quantification was not possible using simple data analysis. In this study, we were able to identify adsorbed components by applying an appropriate statistical technique, factor analysis. In this study, the most strongly associated mass fragment on PM2.5 surfaces exposed to BAL (and undetected on both untreated samples and saline controls) was di-palmitoyl-phosphatidylcholine, a component of lung surfactant. Amino acids were also strongly associated with BAL-exposed PM2.5 surfaces and not other sample types. Thirteen mass fragments were identified, diagnostic of the amino acids alanine, arginine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, serine, and valine. This study provides evidence that lung surfactant and amino acids related to opsonin proteins adsorb to nonbiological particle surfaces exposed to human lung lining fluid. Disruption of normal surfactant function, both physical and immunological, is possible but unproven. Further work on this PM-opsonin interaction is recommended.

scholarly journals Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract

2017 ◽  
Vol 114 (18) ◽  
pp. E3592-E3601 ◽  
Author(s):  
Jenny Marie Andersson ◽  
Carl Grey ◽  
Marcus Larsson ◽  
Tiago Mendes Ferreira ◽  
Emma Sparr
Keyword(s):  
Molecular Structure ◽  
Self Assembly ◽  
Lung Surfactant ◽  
Dry Weight ◽  
Isotopic Labeling ◽  
Lamellar Phase ◽  
Large Set ◽  
Clinical Grade ◽  
Surfactant Mixtures ◽  
Protein Film

The lipid–protein film covering the interface of the lung alveolar in mammals is vital for proper lung function and its deficiency is related to a range of diseases. Here we present a molecular-level characterization of a clinical-grade porcine lung surfactant extract using a multitechnique approach consisting ofH1–C13solid-state nuclear magnetic spectroscopy, small- and wide-angle X-ray scattering, and mass spectrometry. The detailed characterization presented for reconstituted membranes of a lung extract demonstrates that the molecular structure of lung surfactant strongly depends on the concentration of cholesterol. If cholesterol makes up about 11% of the total dry weight of lung surfactant, the surfactant extract adopts a single liquid-ordered lamellar phase,Lα(o), at physiological temperatures. ThisLα(o)phase gradually changes into a liquid-disordered lamellar phase,Lα(d), when the temperature is increased by a few degrees. In the absence of cholesterol the system segregates into one lamellar gel phase and oneLα(d)phase. Remarkably, it was possible to measure a large set of order parameter magnitudes|SCH|from the liquid-disordered and -ordered lamellar phases and assign them to specific C–H bonds of the phospholipids in the biological extract with no use of isotopic labeling. These findings with molecular details on lung surfactant mixtures together with the presented NMR methodology may guide further development of pulmonary surfactant pharmaceuticals that better mimic the physiological self-assembly compositions for treatment of pathological states such as respiratory distress syndrome.

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