Biochemical composition of adult human lung surfactant

Lung ◽  
1982 ◽  
Vol 160 (1) ◽  
pp. 195-206 ◽  
Author(s):  
S. A. Shelley ◽  
J. U. Balis ◽  
J. E. Paciga ◽  
C. G. Espinoza ◽  
A. V. Richman
Keyword(s):  
Biochemical Composition ◽  
Human Lung ◽  
Lung Surfactant ◽  
Adult Human ◽  
Adult Human Lung

Branching pattern of airways and air spaces of a single human terminal bronchiole

1975 ◽  
Vol 38 (6) ◽  
pp. 983-989 ◽  
Author(s):  
J. E. Hansen ◽  
E. P. Ampaya ◽  
G. H. Bryant ◽  
J. J. Navin
Keyword(s):  
Young Adult ◽  
Polyurethane Foam ◽  
First Generation ◽  
Human Lung ◽  
Branching Pattern ◽  
Serial Sections ◽  
Adult Human ◽  
Three Generations ◽  
Terminal Bronchiole ◽  
Adult Human Lung

A polyurethane-foam enlarged reconstruction was made from serial sections of a portion of young adult human lung parenchyman. Study of the progeny of a terminal bronchiole disclosed three generations of respiratory bronchioles and an irregular branching pattern of eight generations of alveolar ducts. Sacs and alveoli arose from the lateral and distal aspects of all generations of ducts. There were an average of 3.5 alveoli per sac. Considering the terminal bronchiole as the first generation branch of the acinus, over 60 per cent of the alveoli counted and predicted were members of the 10–12th generations. The acinus contained one terminal bronchiole and approximately 14 respiratory bronchioles, 1,200–1,500 ducts, 2,500–4,500 sacs, and 14,000–20,000 alveoli.

Characterization of the human pH- and PKA-activated ClC-2G(2 alpha) Cl- channel

1997 ◽  
Vol 273 (2) ◽  
pp. C384-C393 ◽  
Author(s):  
A. M. Sherry ◽  
K. Stroffekova ◽  
L. M. Knapp ◽  
E. Y. Kupert ◽  
J. Cuppoletti ◽  
...  
Keyword(s):  
Human Lung ◽  
Single Channel ◽  
Reversal Potential ◽  
Fetal Lung ◽  
Northern Analysis ◽  
Adult Human ◽  
Cl Channel ◽  
Voltage Curve ◽  
Current Voltage Curve ◽  
Adult Human Lung

A ClC-2G(2 alpha) Cl- channel was identified to be present in human lung and stomach, and a partial cDNA for this Cl- channel was cloned from a human fetal lung library. A full-length expressible human ClC-2G(2 alpha) cDNA was constructed by ligation of mutagenized expressible rabbit ClC-2G(2 alpha) cDNA with the human lung ClC-2G(2 alpha) cDNA, expressed in oocytes, and characterized at the single-channel level. Adenosine 3',5'-cyclic monophosphate-dependent protein kinase (PKA) treatment increased the probability of opening of the channel (Po). After PKA activation, the channel exhibited a linear (r = 0.99) current-voltage curve with a slope conductance of 22.1 +/- 0.8 pS in symmetric 800 mM tetraethylammonium chloride (TEACl; pH 7.4). Under fivefold gradient conditions of TEACl, a reversal potential of +21.5 +/- 2.8 mV was measured demonstrating anion-to-cation discrimination. As previously demonstrated for the rabbit ClC-2G(2 alpha) Cl- channel, the human analog, hClC-2G(2 alpha), was active at pH 7.4 as well as when the pH of the extracellular face of the channel (trans side of the bilayer; pHtrans) was asymmetrically reduced to pH 3.0. The extent of PKA activation was dependent on pHtrans. With PKA treatment, Po increased fourfold with a pHtrans of 7.4 and eightfold with a pHtrans of 3.0. Effects of sequential PKA addition followed by pHtrans reduction on the same channel suggested that the PKA- and pH-dependent increases in channel Po were separable and cumulative. Northern analysis showed ClC-2G(2 alpha) mRNA to be present in human adult and fetal lung and adult stomach, and quantitative reverse transcriptase-polymerase chain reaction showed this channel to be present in the adult human lung and stomach at about one-half the level found in fetal lung. The findings of the present study suggest that the ClC-2G(2 alpha) Cl- channel may play an important role in Cl- transport in the fetal and adult human lung.

scholarly journals Gene transfer to adult human lung tissue ex vivo

Gene Therapy ◽  
2000 ◽  
Vol 7 (8) ◽  
pp. 675-678 ◽  
Author(s):  
S McBride ◽  
D Rannie ◽  
D J Harrison
Keyword(s):  
Gene Transfer ◽  
Lung Tissue ◽  
Human Lung ◽  
Ex Vivo ◽  
Human Lung Tissue ◽  
Adult Human ◽  
Adult Human Lung

scholarly journals CD105-Positive Cells in Pulmonary Arterial Blood of Adult Human Lung Cancer Patients Include Mesenchymal Progenitors

Stem Cells ◽  
2008 ◽  
Vol 26 (10) ◽  
pp. 2523-2530 ◽  
Author(s):  
Haruki Chiba ◽  
Genicihro Ishii ◽  
Ta-Kashi Ito ◽  
Kazuhiro Aoyagi ◽  
Hiroki Sasaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Mesenchymal Progenitors ◽  
Lung Cancer Patients ◽  
Adult Human ◽  
Arterial Blood ◽  
Pulmonary Arterial ◽  
Adult Human Lung

scholarly journals Difference in the apoptotic response of fetal versus adult human lung fibroblasts in collagen gels

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Maria A Navarro Olmo ◽  
Dong Xu ◽  
Mo Rezaiekhaligh ◽  
Sherry Mabry ◽  
Ricardo E Perez ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Fibroblasts ◽  
Collagen Gels ◽  
Apoptotic Response ◽  
Human Lung Fibroblasts ◽  
Adult Human ◽  
Adult Human Lung

Normal Newborn and Adult Human Lung Collagen — Analysis of Types

1977 ◽  
Vol 5 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Daniel J. Hurst ◽  
Kaye H. Kilburn ◽  
William M. Baker
Keyword(s):  
Human Lung ◽  
Adult Human ◽  
Collagen Analysis ◽  
Adult Human Lung

Alpha smooth muscle actin expression in developing and adult human lung

1990 ◽  
Vol 44 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Kevin O. Leslie ◽  
John J. Mitchell ◽  
Janet L. Woodcock-Mitchell ◽  
Robert B. Low
Keyword(s):  
Smooth Muscle ◽  
Human Lung ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Adult Human ◽  
Actin Expression ◽  
Adult Human Lung

scholarly journals Quantitative study of endocrine cells immunoreactive for calcitonin in the normal adult human lung.

Thorax ◽  
1985 ◽  
Vol 40 (11) ◽  
pp. 866-869 ◽  
Author(s):  
J R Gosney ◽  
M C Sissons ◽  
J A O'Malley
Keyword(s):  
Quantitative Study ◽  
Endocrine Cells ◽  
Human Lung ◽  
Normal Adult ◽  
Adult Human ◽  
Adult Human Lung
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