Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21

Biochemistry ◽  
2017 ◽  
Vol 56 (29) ◽  
pp. 3808-3817 ◽  
Author(s):  
Phuong Trang Nguyen ◽  
Ximena Zottig ◽  
Mathew Sebastiao ◽  
Steve Bourgault
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Site Specific ◽  
Asparagine Deamidation

scholarly journals Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

2010 ◽  
Vol 132 (26) ◽  
pp. 8973-8983 ◽  
Author(s):  
Jeffrey R. Brender ◽  
Kevin Hartman ◽  
Ravi Prakash Reddy Nanga ◽  
Nataliya Popovych ◽  
Roberto de la Salud Bea ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study

2008 ◽  
Vol 463 (4-6) ◽  
pp. 396-399 ◽  
Author(s):  
Danilo Milardi ◽  
Matteo Pappalardo ◽  
Martina Pannuzzo ◽  
Domenico M. Grasso ◽  
Carmelo La Rosa
Keyword(s):  
Molecular Dynamics ◽  
Islet Amyloid Polypeptide ◽  
Disulfide Bridge ◽  
Islet Amyloid

Role of islet amyloid polypeptide secretion in insulin-resistant humans

Diabetologia ◽  
1994 ◽  
Vol 37 (2) ◽  
pp. 188-194 ◽  
Author(s):  
A. Kautzky-Willer ◽  
K. Thomaseth ◽  
G. Pacini ◽  
M. Clodi ◽  
B. Ludvik ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Insulin Resistant

Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity

2016 ◽  
Vol 94 (3) ◽  
pp. 341-346 ◽  
Author(s):  
Jessica S. Fortin ◽  
Marie-Odile Benoit-Biancamano ◽  
René C.-Gaudreault
Keyword(s):  
Small Molecules ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Cytotoxic Effects ◽  
Urea Derivatives ◽  
Amyloid Deposits ◽  
Survival Assay

Islet amyloid polypeptide (IAPP) has been shown to form amyloid deposits in pancreatic islets, thereby furthering type 2 diabetes disease progression. Further discovery of new molecules is needed to create a diverse set of molecules that impede pancreatic amyloidosis. We have recently designed and synthesized N-phenyl-N′-(2-ethyl)ureas (EU) that are non-cytotoxic small molecules, to evaluate the role of the aryl-substituted moiety on the inhibition of hIAPP fibrillization. Several EUs were tested in vitro for their anti-amyloidogenic activity using the fluorometric ThT assay, the photo-induced cross-linking (PIUCP) assay, and cell survival assay in pancreatic MIN-6 cells. EU-362 and EU-418 were able to significantly inhibit the formation of hIAPP fibrils and protected cells from amyloid cytotoxic effects. Our results suggest that increasing the nucleophilic potency of the aryl moiety significantly enhances the anti-amyloidogenic activity of the molecules.

scholarly journals Analysis of the Role of the Conserved Disulfide in Amyloid Formation by Human Islet Amyloid Polypeptide in Homogeneous and Heterogeneous Environments

Biochemistry ◽  
2018 ◽  
Vol 57 (21) ◽  
pp. 3065-3074 ◽  
Author(s):  
Zachary Ridgway ◽  
Xiaoxue Zhang ◽  
Amy G. Wong ◽  
Andisheh Abedini ◽  
Ann Marie Schmidt ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Heterogeneous Environments ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

2010 ◽  
Vol 39 (9) ◽  
pp. 1359-1364 ◽  
Author(s):  
Lucie Khemtémourian ◽  
Maarten F. M. Engel ◽  
John A. W. Kruijtzer ◽  
Jo W. M. Höppener ◽  
Rob M. J. Liskamp ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid
Sign in / Sign up

Export Citation Format

Share Document