scholarly journals Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

2010 ◽  
Vol 132 (26) ◽  
pp. 8973-8983 ◽  
Author(s):  
Jeffrey R. Brender ◽  
Kevin Hartman ◽  
Ravi Prakash Reddy Nanga ◽  
Nataliya Popovych ◽  
Roberto de la Salud Bea ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Analysis of the Role of the Conserved Disulfide in Amyloid Formation by Human Islet Amyloid Polypeptide in Homogeneous and Heterogeneous Environments

Biochemistry ◽  
2018 ◽  
Vol 57 (21) ◽  
pp. 3065-3074 ◽  
Author(s):  
Zachary Ridgway ◽  
Xiaoxue Zhang ◽  
Amy G. Wong ◽  
Andisheh Abedini ◽  
Ann Marie Schmidt ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Heterogeneous Environments ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

Human Islet Amyloid Polypeptide Assembly: The Key Role of the 8–20 Fragment

2016 ◽  
Vol 120 (46) ◽  
pp. 11905-11911 ◽  
Author(s):  
Li Wang ◽  
Alexandre I. Ilitchev ◽  
Maxwell J. Giammona ◽  
Fei Li ◽  
Steven K. Buratto ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Cholesterol-sensing role of phenylalanine in the interaction of human islet amyloid polypeptide with lipid bilayers

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40581-40588
Author(s):  
Ruijie Hao ◽  
Yang Li ◽  
Liping Guan ◽  
Tong Lu ◽  
Feihong Meng ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

The interaction of hIAPP with cholesterol in the membrane is mediated by Phe15.

Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans

Diabetes ◽  
1994 ◽  
Vol 43 (5) ◽  
pp. 640-644 ◽  
Author(s):  
E. J. de Koning ◽  
J. W. Hoppener ◽  
J. S. Verbeek ◽  
C. Oosterwijk ◽  
K. L. van Hulst ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals The flanking peptides issue from the maturation of the human islet amyloid polypeptide (hIAPP) slightly modulate hIAPP-fibril formation but not hIAPP-induced cell death

Biochimie ◽  
2020 ◽  
Vol 170 ◽  
pp. 26-35 ◽  
Author(s):  
Shadai Salazar Vazquez ◽  
Bertrand Blondeau ◽  
Pierre Cattan ◽  
Mathieu Armanet ◽  
Ghislaine Guillemain ◽  
...  
Keyword(s):  
Cell Death ◽  
Islet Amyloid Polypeptide ◽  
Fibril Formation ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Regulation of divalent metal ions to the aggregation and membrane damage of human islet amyloid polypeptide oligomers

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12815-12825
Author(s):  
Yajie Wang ◽  
Feihong Meng ◽  
Tong Lu ◽  
Chunyun Wang ◽  
Fei Li
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Membrane Damage ◽  
Islet Amyloid Polypeptide ◽  
Divalent Metal ◽  
Human Islet ◽  
Divalent Metal Ions ◽  
Islet Amyloid ◽  
Induced Membrane ◽  
Human Islet Amyloid Polypeptide

Their is a counteraction between a decrease in the disruptive ability of metal-associated oligomer species and an increase in the quantity of oligomers promoted by the metal binding in the activity of hIAPP induced membrane damage.

scholarly journals Interactions of human islet amyloid polypeptide with lipid structure of different curvatures

2020 ◽  
Vol 10 (6) ◽  
pp. 412-418
Author(s):  
Le Mei ◽  
Wenhui Shen ◽  
Xuwei Wu ◽  
Jie Liu ◽  
Dechang Li ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Lipid Structure ◽  
Human Islet Amyloid Polypeptide

scholarly journals Amyloidogenicity and Cytotoxicity of Recombinant Mature Human Islet Amyloid Polypeptide (rhIAPP)

2004 ◽  
Vol 279 (41) ◽  
pp. 42803-42810 ◽  
Author(s):  
Dahabada H. J. Lopes ◽  
Christian Colin ◽  
Theri L. Degaki ◽  
Ana Christina V. de Sousa ◽  
Marcelo N. N. Vieira ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide
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