scholarly journals Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide

Biochemistry ◽  
2013 ◽  
Vol 52 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Ling-Hsien Tu ◽  
Daniel P. Raleigh
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Aromatic Interactions

scholarly journals Analysis of the Role of the Conserved Disulfide in Amyloid Formation by Human Islet Amyloid Polypeptide in Homogeneous and Heterogeneous Environments

Biochemistry ◽  
2018 ◽  
Vol 57 (21) ◽  
pp. 3065-3074 ◽  
Author(s):  
Zachary Ridgway ◽  
Xiaoxue Zhang ◽  
Amy G. Wong ◽  
Andisheh Abedini ◽  
Ann Marie Schmidt ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Heterogeneous Environments ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals The Role of the 14–20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Sharon Gilead ◽  
Ehud Gazit
Keyword(s):  
Molecular Recognition ◽  
Molecular Mechanism ◽  
Amyloid Fibrils ◽  
Recent Literature ◽  
Islet Amyloid Polypeptide ◽  
Supporting Evidence ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Human And Mouse

The molecular mechanism of amyloid formation by the islet amyloid polypeptide (IAPP) has been intensively studied since its identification in the late 1980s. The IAPP(20–29) region is considered to be the central amyloidogenic module of the polypeptide. This assumption is mainly based on the amyloidogenic properties of the region and on the large sequence diversity within this region between the human and mouse IAPP, as the mouse IAPP does not form amyloids. A few years ago, another region within IAPP was identified that seems to be at least as important as IAPP(20–29) in facilitation of molecular recognition that leads to amyloid formation. Here, we reinforce our and others' previous findings by analyzing supporting evidence from the recent literature. Moreover, we provide new proofs to our hypothesis by comparing between the amyloidogenic properties of the two regions derived from the IAPP of cats, which is also known to form amyloid fibrils.

scholarly journals Matrix Metalloproteinase-9 Reduces Islet Amyloid Formation by Degrading Islet Amyloid Polypeptide

2012 ◽  
Vol 288 (5) ◽  
pp. 3553-3559 ◽  
Author(s):  
Kathryn Aston-Mourney ◽  
Sakeneh Zraika ◽  
Jayalakshmi Udayasankar ◽  
Shoba L. Subramanian ◽  
Pattie S. Green ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Islet Amyloid Polypeptide ◽  
Matrix Metalloproteinase 9 ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Metalloproteinase 9

scholarly journals Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation

2014 ◽  
Vol 106 (7) ◽  
pp. 1520-1527 ◽  
Author(s):  
Ling-Hsien Tu ◽  
Arnaldo L. Serrano ◽  
Martin T. Zanni ◽  
Daniel P. Raleigh
Keyword(s):  
Mutational Analysis ◽  
Amyloid Formation ◽  
Islet Amyloid

Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21

Biochemistry ◽  
2017 ◽  
Vol 56 (29) ◽  
pp. 3808-3817 ◽  
Author(s):  
Phuong Trang Nguyen ◽  
Ximena Zottig ◽  
Mathew Sebastiao ◽  
Steve Bourgault
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Site Specific ◽  
Asparagine Deamidation
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