scholarly journals Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State Analogue

Biochemistry ◽  
2016 ◽  
Vol 55 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Aamir Mir ◽  
Barbara L. Golden
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Active Site ◽  
Hammerhead Ribozyme ◽  
Divalent Ions ◽  
Transition State Analogue

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue

Science ◽  
1990 ◽  
Vol 250 (4987) ◽  
pp. 1560-1563 ◽  
Author(s):  
S. White ◽  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Phospholipase A2 ◽  
Cobra Venom ◽  
Transition State Analogue

Structure and Conformations of Gaba-Transaminase Inhibitors. II. Transition-State Analogs

1986 ◽  
Vol 39 (10) ◽  
pp. 1575 ◽  
Author(s):  
PR Andrews ◽  
V Cody ◽  
JM Gulbis ◽  
MN Iskander ◽  
AI Jeffrey ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Crystal Structures ◽  
Gaba Transaminase ◽  
Preceding Article ◽  
Transition State Analogs ◽  
Calculated Energy ◽  
Transition State Analogue ◽  
Oxazine Ring ◽  
Transition State Analogue Inhibitors

Crystal structures of two benzoxazine derivatives designed as transition state analogue inhibitors of GABA-T were determined. These cyclic oxazine structures are shown to be more similar to the proposed transition state than the pyridoxal derivatives reported in the preceding article.1 Conformational analyses (non-bonded energy, MINDO/3, MNDO) show that the crystal structures are close to the calculated energy minima. The MNDO parameterization gives geometries close to the crystal structure, with the configuration at the nitrogen of the oxazine ring in particular being better reproduced than by the MINDO/3 method, which tends to prefer planar (sp2) nitrogen.

Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue

Science ◽  
1990 ◽  
Vol 250 (4987) ◽  
pp. 1563-1566 ◽  
Author(s):  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Phospholipase A2 ◽  
Bee Venom ◽  
Transition State Analogue

scholarly journals A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site

2006 ◽  
Vol 103 (40) ◽  
pp. 14732-14737 ◽  
Author(s):  
N. J. Baxter ◽  
L. F. Olguin ◽  
M. Golicnik ◽  
G. Feng ◽  
A. M. Hounslow ◽  
...  
Keyword(s):  
Transition State ◽  
Active Site ◽  
Trojan Horse ◽  
Enzyme Active Site ◽  
Transition State Analogue
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