gaba transaminase
Recently Published Documents


TOTAL DOCUMENTS

259
(FIVE YEARS 7)

H-INDEX

38
(FIVE YEARS 0)

2021 ◽  
pp. 136-142
Author(s):  
Oshi Amira ◽  
Alfaifi Abdullah ◽  
Z. Seidahmed Mohammed ◽  
Al Hussein Khalid ◽  
Miqdad Abeer ◽  
...  

Cell Reports ◽  
2021 ◽  
Vol 36 (4) ◽  
pp. 109475
Author(s):  
Vahan Martirosian ◽  
Krutika Deshpande ◽  
Hao Zhou ◽  
Keyue Shen ◽  
Kyle Smith ◽  
...  

Cell Reports ◽  
2021 ◽  
Vol 35 (13) ◽  
pp. 109302
Author(s):  
Vahan Martirosian ◽  
Krutika Deshpande ◽  
Hao Zhou ◽  
Keyue Shen ◽  
Kyle Smith ◽  
...  

2021 ◽  
Author(s):  
Amira Oshi ◽  
Abdullah Alfaifi ◽  
Mohammed Z. Seidahmed ◽  
Khalid Al Hussein ◽  
Abeer Miqdad ◽  
...  

2021 ◽  
Vol 36 (1) ◽  
pp. 2016-2024
Author(s):  
Mingu Gordon Park ◽  
Ah-reum Han ◽  
Su Yeon Kim ◽  
Tai Young Kim ◽  
Ho Min Kim ◽  
...  

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii225-ii226
Author(s):  
Vahan Martirosian ◽  
Krutika Deshpande ◽  
Hao Zhou ◽  
Keyue Shen ◽  
Vazgen Stepanosyan ◽  
...  

Abstract Medulloblastoma (MB) is a malignant pediatric brain tumor. Studies have shown heterogeneous cells amongst the tumor bulk which mirror normal neural cells in various neurodevelopmental stages. To discern exploited mechanisms promoting MB leptomeningeal disease, we drew conclusions from developmental neurobiology. In normal differentiation, the metabolic phenotype in proliferating neural progenitor cells evolves from a glycolysis-dependent to an oxidative phosphorylation-reliant energetic profile in quiescent differentiated neurons. Cancer cells mirror this evolution, which also grants them the capability to utilize alternative nutrients in the microenvironment as an energy source. Considering metastatic cells are typically in a dormant state and primarily utilize oxidative phosphorylation, we hypothesized metastatic MB cells emulate a quiescent neuron-like cellular profile to survive in the cerebrospinal fluid and form leptomeningeal metastases. To examine this, we query the expression of GABA catabolic enzyme GABA transaminase (ABAT) in MB. GABA is found in the cerebellar and leptomeningeal microenvironments, and is utilized by metastatic cancer cells in the CNS as an energy source. We correlate an increase in ABAT expression with neurodevelopment and show heterogeneous expression of this protein in primary MB tumors. MB cells with increased expression of ABAT were slower-dividing, expressed a genetic and metabolic phenotype reminiscent of quiescent neuron-like cells, and had increased capability to metabolize GABA. Conversely, lower expression of ABAT was associated with an increased proliferation rate and correlated with a progenitor-like cellular profile. Transplantation of MB cells into the leptomeningeal compartment decreased proliferative capacity and enhanced ABAT expression. Xenograft models showed MB cells with ABAT knockdown had increased growth in the cerebellar microenvironment. Conversely, MB cells with ABAT overexpression transplanted into the cerebrospinal fluid formed leptomeningeal metastases whereas ABAT knockdown cells could not. These results suggest ABAT expression in MB cells can be modulated by the tumor microenvironment and is required to form leptomeningeal metastases.


2020 ◽  
Vol 13 ◽  
Author(s):  
Adam D. Kennedy ◽  
Kirk L. Pappan ◽  
Taraka Donti ◽  
Mauricio R. Delgado ◽  
Marwan Shinawi ◽  
...  

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S123-S124
Author(s):  
Lee Wonseok ◽  
Park Min Gu ◽  
Woo Junsung ◽  
C. Justin Lee ◽  
Yoon Boeun

Sign in / Sign up

Export Citation Format

Share Document