scholarly journals Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition

Biochemistry ◽  
2015 ◽  
Vol 54 (20) ◽  
pp. 3173-3182 ◽  
Author(s):  
Tiffany Tsui ◽  
W. Todd Miller
Keyword(s):  
Enzyme Activity ◽  
Breast Tumor ◽  
Substrate Recognition ◽  
Breast Tumor Kinase

scholarly journals Deregulation of the cell cycle by breast tumor kinase (Brk)

2010 ◽  
Vol 127 (11) ◽  
pp. 2723-2731 ◽  
Author(s):  
Edward Chan ◽  
Anjaruwee S. Nimnual
Keyword(s):  
Cell Cycle ◽  
Breast Tumor ◽  
Breast Tumor Kinase

scholarly journals Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3601
Author(s):  
Raja Mohanrao ◽  
Ruth Manorama ◽  
Shubhra Ganguli ◽  
Mithun C. Madhusudhanan ◽  
Rashna Bhandari ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Atpase Activity ◽  
Catalytic Domain ◽  
Inositol Phosphate ◽  
Substrate Recognition ◽  
Competitive Inhibitor ◽  
Inositol Polyphosphates ◽  
Inositol Pyrophosphate ◽  
Phosphate Donor ◽  
Inositol Pyrophosphates

IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis. In this context, we synthesized four scyllo-inositol polyphosphates—scyllo-IP5, scyllo-IP6, scyllo-IP7 and Bz-scyllo-IP5—from myo-inositol and studied their activity as substrates for mouse IP6K1 and the catalytic domain of VIP1, the budding yeast variant of PPIP5K. We incubated these scyllo-inositol polyphosphates with these kinases and ATP as the phosphate donor. We tracked enzyme activity by measuring the amount of radiolabeled scyllo-inositol pyrophosphate product formed and the amount of ATP consumed. All scyllo-inositol polyphosphates are substrates for both the kinases but they are weaker than the corresponding myo-inositol phosphate. Our study reveals the importance of axial-hydroxyl/phosphate for IP6K1 substrate recognition. We found that all these derivatives enhance the ATPase activity of VIP1. We found very weak ligand-induced ATPase activity for IP6K1. Benzoyl-scyllo-IP5 was the most potent ligand to induce IP6K1 ATPase activity despite being a weak substrate. This compound could have potential as a competitive inhibitor.

Breast Tumor Kinase (Brk)

2012 ◽  
pp. 203-203
Author(s):  
Zuzana Saidak ◽  
Zakaria Ezzoukhry ◽  
Jean-Claude Maziere ◽  
Antoine Galmiche ◽  
Ken-Ichi Takemaru ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Breast Tumor Kinase

scholarly journals Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sayem Miah ◽  
Edward Bagu ◽  
Raghuveera Goel ◽  
Yetunde Ogunbolude ◽  
Chenlu Dai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Tumor ◽  
Breast Cancer Cells ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling ◽  
Breast Tumor Kinase

scholarly journals Breast Tumor Kinase (Protein Tyrosine Kinase 6) Regulates Heregulin-Induced Activation of ERK5 and p38 MAP Kinases in Breast Cancer Cells

2007 ◽  
Vol 67 (9) ◽  
pp. 4199-4209 ◽  
Author(s):  
Julie Hanson Ostrander ◽  
Andrea R. Daniel ◽  
Kristopher Lofgren ◽  
Celina G. Kleer ◽  
Carol A. Lange
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Breast Tumor ◽  
Breast Cancer Cells ◽  
Protein Tyrosine Kinase ◽  
Map Kinases ◽  
Protein Tyrosine ◽  
Breast Tumor Kinase

Overexpression of PTK6 (breast tumor kinase) protein—a prognostic factor for long-term breast cancer survival—is not due to gene amplification

2009 ◽  
Vol 455 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Michaela Aubele ◽  
Sanja Vidojkovic ◽  
Herbert Braselmann ◽  
Dominique Ritterswürden ◽  
Gert Auer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Gene Amplification ◽  
Breast Tumor ◽  
Cancer Survival ◽  
Protein A ◽  
Breast Cancer Survival ◽  
Breast Tumor Kinase
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