scholarly journals Deregulation of the cell cycle by breast tumor kinase (Brk)

2010 ◽  
Vol 127 (11) ◽  
pp. 2723-2731 ◽  
Author(s):  
Edward Chan ◽  
Anjaruwee S. Nimnual
Keyword(s):  
Cell Cycle ◽  
Breast Tumor ◽  
Breast Tumor Kinase

scholarly journals Tyrosine Phosphorylation of Sam68 by Breast Tumor Kinase Regulates Intranuclear Localization and Cell Cycle Progression

2005 ◽  
Vol 280 (46) ◽  
pp. 38639-38647 ◽  
Author(s):  
Kiven Erique Lukong ◽  
Daniel Larocque ◽  
Angela L. Tyner ◽  
Stéphane Richard
Keyword(s):  
Cell Cycle ◽  
Tyrosine Phosphorylation ◽  
Breast Tumor ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Breast Tumor Kinase

Breast Tumor Kinase (Brk)

2012 ◽  
pp. 203-203
Author(s):  
Zuzana Saidak ◽  
Zakaria Ezzoukhry ◽  
Jean-Claude Maziere ◽  
Antoine Galmiche ◽  
Ken-Ichi Takemaru ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Breast Tumor Kinase

scholarly journals Roquin1 Suppresses Breast Cancer Growth by Inducing Cell Cycle Arrest via Selectively Destabilizing Cell Cycle–Promoting Gene mRNAs

2020 ◽  
Author(s):  
Wenbao Lu ◽  
Meicen Zhou ◽  
Bing Wang ◽  
Xueting Liu ◽  
Bingwei Li
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Breast Cancer Cell ◽  
Breast Tumor ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Cycle Arrest

Abstract Background: Dysregulation of cell cycle progression is one of the common features of human cancer cells, however, its mechanism remains unclear. This study aims to clarify the role and the underlying mechanisms of Roquin1 in cell cycle arrest induction in breast cancer.Methods: Public cancer databases were analyzed to identify the expression pattern of Roquin1 in human breast cancers and the significant association with patient survival. Quantitative real-time PCR and western blots were performed to detect the expression of Roquin1 in breast cancer samples and cell lines. Cell counting, MTT assay, flow cytometry, and in vivo study were conducted to investigate the effects of Roquin1 on cell proliferation, cell cycle progression and tumor progression. RNA-sequencing was applied to identify the differential genes and pathways regulated by Roquin1. RNA immunoprecipitation assay, luciferase reporter assay, mRNA half-life detection, RNA affinity binding assay, and RIP-ChIP were used to explore the molecular mechanisms of Roquin1.Results: We showed that Roquin1 expression in breast cancer tissues and cell lines was inhibited, and the reduction in Roquin1 expression was associated with poor overall survival and relapse free survival of patients with breast cancer. Roquin1 overexpression inhibited breast cancer cell proliferation and induced G1/S cell cycle arrest without causing significant apoptosis. In contrast, knockdown of Roquin1 promoted breast cancer cell growth and cycle progression. Moreover, in vivo induction of Roquin1 by adenovirus significantly suppressed breast tumor growth and metastasis. Mechanistically, Roquin1 selectively destabilizing cell cycle–promoting genes, including Cyclin D1, Cyclin E1, cyclin dependent kinase 6 (CDK6) and minichromosome maintenance 2 (MCM2) through targeting the stem–loop structure in the 3’untranslated region (3’UTR) of mRNAs via its ROQ domain, leading to the downregulation of cell cycle–promoting mRNAs.Conclusions: Our findings demonstrated that Roquin1 was a novel breast tumor suppressor and could induce G1/S cell cycle arrest by selectively downregulating the expression of cell cycle–promoting genes, which might as a potential molecular target for breast cancer treatment.

scholarly journals Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sayem Miah ◽  
Edward Bagu ◽  
Raghuveera Goel ◽  
Yetunde Ogunbolude ◽  
Chenlu Dai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Tumor ◽  
Breast Cancer Cells ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling ◽  
Breast Tumor Kinase

scholarly journals Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 41679-41691 ◽  
Author(s):  
Li Xu ◽  
Huan Ning ◽  
Ling Gu ◽  
Qinghong Wang ◽  
Wenbao Lu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Tumor Cells ◽  
Breast Tumor ◽  
Breast Tumor Cells ◽  
Cycle Arrest

scholarly journals Breast Tumor Kinase (Protein Tyrosine Kinase 6) Regulates Heregulin-Induced Activation of ERK5 and p38 MAP Kinases in Breast Cancer Cells

2007 ◽  
Vol 67 (9) ◽  
pp. 4199-4209 ◽  
Author(s):  
Julie Hanson Ostrander ◽  
Andrea R. Daniel ◽  
Kristopher Lofgren ◽  
Celina G. Kleer ◽  
Carol A. Lange
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Breast Tumor ◽  
Breast Cancer Cells ◽  
Protein Tyrosine Kinase ◽  
Map Kinases ◽  
Protein Tyrosine ◽  
Breast Tumor Kinase
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