Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

Guanbo Wang; Igor A. Kaltashov

doi:10.1021/ac501789e

Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac501789e ◽

2014 ◽

Vol 86 (15) ◽

pp. 7293-7298 ◽

Cited By ~ 16

Author(s):

Guanbo Wang ◽

Igor A. Kaltashov

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

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Comparative higher-order structure analysis of antibody biosimilars using combined bottom-up and top-down hydrogen-deuterium exchange mass spectrometry

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2016.08.013 ◽

2016 ◽

Vol 1864 (12) ◽

pp. 1801-1808 ◽

Cited By ~ 19

Author(s):

Jingxi Pan ◽

Suping Zhang ◽

Christoph H. Borchers

Keyword(s):

Mass Spectrometry ◽

Structure Analysis ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Top-down mass spectrometry and hydrogen/deuterium exchange for comprehensive structural characterization of interferons: Implications for biosimilars

PROTEOMICS ◽

10.1002/pmic.201300341 ◽

2014 ◽

Vol 14 (10) ◽

pp. 1249-1258 ◽

Cited By ~ 16

Author(s):

Jingxi Pan ◽

Christoph H. Borchers

Keyword(s):

Mass Spectrometry ◽

Structural Characterization ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

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Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry

Journal of Visualized Experiments ◽

10.3791/62672 ◽

2021 ◽

Author(s):

Lingxiao Chaihu ◽

Xiaopeng Yao ◽

Xiang Xu ◽

Zhongqin Zhu ◽

David D. Y. Chen ◽

...

Keyword(s):

Mass Spectrometry ◽

Capillary Electrophoresis ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Drug Discovery Today ◽

10.1016/j.drudis.2013.07.019 ◽

2014 ◽

Vol 19 (1) ◽

pp. 95-102 ◽

Cited By ~ 130

Author(s):

Hui Wei ◽

Jingjie Mo ◽

Li Tao ◽

Reb J. Russell ◽

Adrienne A. Tymiak ◽

...

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-014-7924-3 ◽

2014 ◽

Vol 406 (26) ◽

pp. 6541-6558 ◽

Cited By ~ 57

Author(s):

Richard Y.-C. Huang ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

Characterization of Protein Therapeutics using Mass Spectrometry ◽

10.1007/978-1-4419-7862-2_8 ◽

2013 ◽

pp. 305-341 ◽

Cited By ~ 1

Author(s):

Hui Wei ◽

Adrienne A. Tymiak ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Probing the Higher Order Structure of Proteins by Hydrogen/Deuterium Exchange and Mass Spectrometry.

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.48.94 ◽

2000 ◽

Vol 48 (2) ◽

pp. 94-100 ◽

Cited By ~ 2

Author(s):

Satoko AKASHI ◽

Koji TAKIO

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

Structure Of Proteins

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Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

ChemBioChem ◽

10.1002/cbic.200890061 ◽

2008 ◽

Vol 9 (16) ◽

pp. 2549-2549

Author(s):

Michael B. Tropak ◽

Gregory J. Kornhaber ◽

Brigitte A. Rigat ◽

Gustavo H. Maegawa ◽

Justin D. Buttner ◽

...

Keyword(s):

Mass Spectrometry ◽

Gaucher Disease ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Pharmacological Chaperones ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Picture Identification

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Analysis of Higher Order Structures of Proteins by Hydrogen Deuterium Exchange Mass Spectrometry

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.s18-44 ◽

2018 ◽

Vol 66 (6) ◽

pp. 218-221

Author(s):

Tetsuo Torisu ◽

Hiroaki Oyama ◽

Susumu Uchiyama

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Order Structures

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Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac802575y ◽

2009 ◽

Vol 81 (7) ◽

pp. 2644-2651 ◽

Cited By ~ 137

Author(s):

Damian Houde ◽

Joseph Arndt ◽

Wayne Domeier ◽

Steven Berkowitz ◽

John R. Engen

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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