Probing the Higher Order Structure of Proteins by Hydrogen/Deuterium Exchange and Mass Spectrometry.

Satoko AKASHI; Koji TAKIO

doi:10.5702/massspec.48.94

Probing the Higher Order Structure of Proteins by Hydrogen/Deuterium Exchange and Mass Spectrometry.

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.48.94 ◽

2000 ◽

Vol 48 (2) ◽

pp. 94-100 ◽

Cited By ~ 2

Author(s):

Satoko AKASHI ◽

Koji TAKIO

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

Structure Of Proteins

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Drug Discovery Today ◽

10.1016/j.drudis.2013.07.019 ◽

2014 ◽

Vol 19 (1) ◽

pp. 95-102 ◽

Cited By ~ 130

Author(s):

Hui Wei ◽

Jingjie Mo ◽

Li Tao ◽

Reb J. Russell ◽

Adrienne A. Tymiak ◽

...

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Comparative higher-order structure analysis of antibody biosimilars using combined bottom-up and top-down hydrogen-deuterium exchange mass spectrometry

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2016.08.013 ◽

2016 ◽

Vol 1864 (12) ◽

pp. 1801-1808 ◽

Cited By ~ 19

Author(s):

Jingxi Pan ◽

Suping Zhang ◽

Christoph H. Borchers

Keyword(s):

Mass Spectrometry ◽

Structure Analysis ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac501789e ◽

2014 ◽

Vol 86 (15) ◽

pp. 7293-7298 ◽

Cited By ~ 16

Author(s):

Guanbo Wang ◽

Igor A. Kaltashov

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Hydrogen Deuterium ◽

Top Down Mass Spectrometry

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Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

Characterization of Protein Therapeutics using Mass Spectrometry ◽

10.1007/978-1-4419-7862-2_8 ◽

2013 ◽

pp. 305-341 ◽

Cited By ~ 1

Author(s):

Hui Wei ◽

Adrienne A. Tymiak ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Analysis of Higher Order Structures of Proteins by Hydrogen Deuterium Exchange Mass Spectrometry

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.s18-44 ◽

2018 ◽

Vol 66 (6) ◽

pp. 218-221

Author(s):

Tetsuo Torisu ◽

Hiroaki Oyama ◽

Susumu Uchiyama

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Order Structures

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Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-014-7924-3 ◽

2014 ◽

Vol 406 (26) ◽

pp. 6541-6558 ◽

Cited By ~ 57

Author(s):

Richard Y.-C. Huang ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Impact of Glycosylation on the Comparability of the Higher-Order Structures in Idursulfase by Hydrogen–Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.0c00661 ◽

2020 ◽

Vol 92 (12) ◽

pp. 8306-8314

Author(s):

Chris Barton ◽

Xuesong Scott Li ◽

Siyang Peter Li ◽

Brian Flaherty ◽

Lionel Sison ◽

...

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Order Structures

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Pinpointing changes in higher-order protein structure by hydrogen/deuterium exchange coupled to electron transfer dissociation mass spectrometry

International Journal of Mass Spectrometry ◽

10.1016/j.ijms.2012.08.010 ◽

2013 ◽

Vol 338 ◽

pp. 2-10 ◽

Cited By ~ 20

Author(s):

Kasper D. Rand

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Protein Structure ◽

Electron Transfer Dissociation ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium

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Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

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