Bilinear Temperature Gradient Focusing in a Hybrid PDMS/Glass Microfluidic Chip Integrated with Planar Heaters for Generating Temperature Gradients

2012 ◽  
Vol 84 (6) ◽  
pp. 2968-2973 ◽  
Author(s):  
Seyed Mostafa Shameli ◽  
Tomasz Glawdel ◽  
Zhen Liu ◽  
Carolyn L. Ren
Keyword(s):  
Temperature Gradient ◽  
Microfluidic Chip ◽  
Temperature Gradients ◽  
Temperature Gradient Focusing

Temperature gradient focusing in a PDMS/glass hybrid microfluidic chip

2007 ◽  
Vol 28 (24) ◽  
pp. 4606-4611 ◽  
Author(s):  
Takuya Matsui ◽  
Joachim Franzke ◽  
Andreas Manz ◽  
Dirk Janasek
Keyword(s):  
Temperature Gradient ◽  
Microfluidic Chip ◽  
Temperature Gradient Focusing

Design of Liquid-Metals Heating-Induced Temperature Gradient Focusing in Microfluidic Channels

2012 ◽  
Author(s):  
Meng Gao ◽  
Lin Gui ◽  
Jing Liu
Keyword(s):  
Temperature Gradient ◽  
Microfluidic Chip ◽  
Liquid Metals ◽  
Electrical Current ◽  
Microfluidic Channels ◽  
Linear Temperature ◽  
Linear Temperature Gradient ◽  
Temperature Gradient Focusing ◽  
Clear Guideline ◽  
A New Technique

Temperature gradient focusing (TGF) is a highly efficient focusing technique for the concentration and separation of charged analytes in microfluidic channels. Design and control of an appropriate temperature gradient are very important for protein concentration and separation. In this study, we propose a new technique to generate the temperature gradient for the focusing purpose. This technique utilizes a microchannel filled with liquid-metals as a heater in the microfluidic chip. By applying electrical current, the liquid-metal microchannel generates Joule heat to form temperature gradient in the microfluidic chip. To optimize the temperature gradient, several typical designs were investigated. The results show the best design which provides the largest linear temperature gradient. The parametric studies present a clear guideline for designing aTGF microfluidic chip.

scholarly journals The principle of minimum entropy production and snow structure

2004 ◽  
Vol 50 (170) ◽  
pp. 342-352 ◽  
Author(s):  
Perry Bartelt ◽  
Othmar Buser
Keyword(s):  
Mass Transfer ◽  
Temperature Gradient ◽  
Entropy Production ◽  
Surface Curvature ◽  
The State ◽  
Temperature Gradients ◽  
Curvature Radius ◽  
Minimum Entropy ◽  
Snow Layer ◽  
Minimum Entropy Production

AbstractAn essential problem in snow science is to predict the changing form of ice grains within a snow layer. Present theories are based on the idea that form changes are driven by mass diffusion induced by temperature gradients within the snow cover. This leads to the well-established theory of isothermal- and temperature-gradient metamorphism. Although diffusion theory treats mass transfer, it does not treat the influence of this mass transfer on the form — the curvature radius of the grains and bonds — directly. Empirical relations, based on observations, are additionally required to predict flat or rounded surfaces. In the following, we postulate that metamorphism, the change of ice surface curvature and size, is a process of thermodynamic optimization in which entropy production is minimized. That is, there exists an optimal surface curvature of the ice grains for a given thermodynamic state at which entropy production is stationary. This state is defined by differences in ice and air temperature and vapor pressure across the interfacial boundary layer. The optimal form corresponds to the state of least wasted work, the state of minimum entropy production. We show that temperature gradients produce a thermal non-equilibrium between the ice and air such that, depending on the temperature, flat surfaces are required to mimimize entropy production. When the temperatures of the ice and air are equal, larger curvature radii are found at low temperatures than at high temperatures. Thus, what is known as isothermal metamorphism corresponds to minimum entropy production at equilibrium temperatures, and so-called temperature-gradient metamorphism corresponds to minimum entropy production at none-quilibrium temperatures. The theory is in good agreement with general observations of crystal form development in dry seasonal alpine snow.

Joule Heating Induced Temperature Gradient Focusing for Microfluidic Concentration of Samples

2010 ◽  
Author(s):  
Zhengwei Ge ◽  
Chun Yang
Keyword(s):  
Temperature Gradient ◽  
Electric Field ◽  
Joule Heating ◽  
Field Experiments ◽  
Dc Voltage ◽  
Sample Concentration ◽  
Great Achievement ◽  
Temperature Gradient Focusing ◽  
Concentration Enhancement ◽  
High Frequency Ac

Microfluidic concentration of sample species is achieved using the temperature gradient focusing (TGF) in a microchannel with a step change in the cross-section under a pure direct current (DC) field or a combined alternating current (AC) and DC electric field. Experiments were carried out to study the effects of applied voltage, buffer concentration and channel size on sample concentration in the TGF processes. These effects were analyzed and summarized using a dimensionless Joule number that is introduced in this study. In addition, Joule number effect in the Poly-dimethylsiloxane (PDMS)/PDMS microdevice was compared with the PDMS/Glass microdevice. A more than 450-fold concentration enhancement was obtained within 75 seconds in the PDMS/PDMS microdevice. Results also showed that the high frequency AC electric field which contributes to produce the temperature gradient and reduces the required DC voltage for the sample concentration. The lower DC voltage has generated slower electroosmotic flow (EOF), which reduces the backpressure effect associated with the finite reservoir size. Finally, a more than 2500-fold concentration enhancement was obtained within 14 minutes in the PDMS/PDMS microdevice, which was a great achievement in this TGF technique using inherent Joule heating effects.

Optothermal Analyte Manipulation With Temperature Gradient Focusing

2010 ◽  
Author(s):  
M. Akbari ◽  
M. Bahrami ◽  
D. Sinton
Keyword(s):  
Temperature Gradient ◽  
Heat Source ◽  
Optical System ◽  
Fluorescent Dye ◽  
Source Position ◽  
Video Projector ◽  
Temperature Gradient Focusing ◽  
Arbitrary Location ◽  
And Control ◽  
Preconcentration Method

An optothermal analyte preconcentration method is introduced in this work based on temperature gradient focusing. The present approach offers a flexible, noncontact technique for focusing and transporting of analytes. Here, we use a commercial video projector and an optical system to generate heat and control the heat source position, size and power. This heater is used to focus a sample model analyte, fluorescent dye, at an arbitrary location along the microchannel. Optothermal manipulation of the focused band was demonstrated by projecting a series of images with a moving light band.

XXV.—The Determination of Temperature Gradients over the Greenland Ice Sheet by Optical Methods

1957 ◽  
Vol 64 (4) ◽  
pp. 381-397
Author(s):  
R. A. Hamilton
Keyword(s):  
Temperature Gradient ◽  
Ice Sheet ◽  
Greenland Ice Sheet ◽  
Temperature Gradients ◽  
Lower Atmosphere ◽  
Optical Methods ◽  
Snow Surface ◽  
Vertical Angle ◽  
Gradient Measurements

SynopsisThe temperature gradient in the lower atmosphere can be directly determined by measuring the optical refractive index of the air. This method is suitable for use on the Greenland ice sheet where errors introduced by water vapour are small, and where the strong solar radiation reflected by the snow surface makes it difficult to measure temperature differences over height differences of about I metre.The refraction was measured by observing the apparent vertical angle of each of a set of targets at distances up to 4 km. from a theodolite. The refraction was found to vary linearly with the distance of the target. The true vertical angle to the targets was determined when a second theodolite was available and reciprocal sights could be taken with it from the site of target to the fixed theodolite. The true vertical angle varied with time due to slow descent of the theodolite as the firn slumped; a correction for this was made. The standard error of the temperature gradient measurements was about 1.5 × 10−2 C.° per metre. It is considered that the method could be developed and improved so that over a range of only 100 metres temperature gradients could be measured to an accuracy of about 0·1° C. per metre.

Microfluidic concentration enhancement of bio-analyte by temperature gradient focusing via Joule heating by DC plus AC field: A numerical approach

2021 ◽  
pp. 1-17
Author(s):  
Amitava Dutta ◽  
Apurba Kumar Santra ◽  
Ranjan Ganguly
Keyword(s):  
Temperature Gradient ◽  
Joule Heating ◽  
Phosphate Buffer ◽  
Phosphate Buffer Solution ◽  
Numerical Approach ◽  
High Concentration ◽  
Buffer Solution ◽  
Temperature Gradient Focusing ◽  
Ac Field ◽  
Target Analyte

Abstract We present a detailed numerical analysis of electrophoresis induced concentration of a bio-analyte facilitated by temperature gradient focusing in a phosphate buffer solution via Joule heating inside a converging-diverging microchannel. The purpose is to study the effects of frequency of AC field and channel width variation on the concentration of target analyte. We tune the buffer viscosity, conductivity and electrophoretic mobility of the analyte such that the electrophoretic velocity of the analyte locally balances the electroosmotic flow of the buffer, resulting in a local build-up of the analyte concentration in a target region. An AC field is superimposed on the applied DC field within the microchannel in such a way that the back pressure effect is minimized, resulting in minimum dispersion and high concentration of the target analyte. Axial transport of fluorescein-Na in the phosphate buffer solution is controlled by inducing temperature gradient through Joule heating. The technique leverages the fact that the buffer's ionic strength and viscosity depends on temperature, which in turn guides the analyte transport. A numerical model is proposed and a finite element-based solution of the coupled electric field, mass, momentum, energy and species equations are carried out. Simulation predict peak of 670-fold concentration of fluorescein-Na is achieved. The peak concentration is found to increase sharply as the channel throat width, while the axial spread of concentrated analyte increases at lower frequency of AC field. The results of the work may improve the design of micro concentrator.

Counterflow Rejection of Adsorbing Proteins for Characterization of Biomolecular Interactions by Temperature Gradient Focusing

2008 ◽  
Vol 80 (1) ◽  
pp. 172-178 ◽  
Author(s):  
Matthew S. Munson ◽  
J. Mark Meacham ◽  
Laurie E. Locascio ◽  
David Ross
Keyword(s):  
Temperature Gradient ◽  
Biomolecular Interactions ◽  
Temperature Gradient Focusing

Effects of Age and Overhead Illumination on Temperatures Preferred by Underyearling Rainbow Trout, Salmo gairdneri, in a Vertical Temperature Gradient

1978 ◽  
Vol 35 (11) ◽  
pp. 1430-1433 ◽  
Author(s):  
Wen-Hwa Kwain ◽  
Robert W. McCauley
Keyword(s):  
Rainbow Trout ◽  
Temperature Gradient ◽  
Temperature Gradients ◽  
Salmo Gairdneri ◽  
Vertical Temperature Gradient ◽  
Temperature Preference ◽  
Vertical Temperature ◽  
Preferred Temperature ◽  
Distribution Of Fish ◽  
Vertical Gradients

During their first 12 mo of life rainbow trout, Salmo gairdneri, preferred progressively cooler temperatures as they grew older; 19 °C was selected during the 1st mo and the selected temperature declined by intervals of 0.5 °C for each of the following months up to the 3rd mo. Fish swam higher in temperature gradients exposed to overhead illumination than in those in total darkness. This trend was reversed during the following 9 mo. These findings demonstrate the important role that age plays in the temperature preference of this species and the influence that overhead light may have on the distribution of fish in vertical gradients. Key words: preferred temperature, age, Salmo gairdneri, light gradients

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