scholarly journals The Italian Twin Registry: An Update at 18 Years From Its Inception

2019 ◽  
Vol 22 (6) ◽  
pp. 572-578
Author(s):  
Emanuela Medda ◽  
Virgilia Toccaceli ◽  
Corrado Fagnani ◽  
Lorenza Nisticò ◽  
Sonia Brescianini ◽  
...  
Keyword(s):  
Age Groups ◽  
Population Based ◽  
International Studies ◽  
Questionnaire Data ◽  
Twin Registry ◽  
Health Related ◽  
Research Initiatives ◽  
Population Based Registry ◽  
Age Range ◽  
Research Period

AbstractThe Italian Twin Registry (ITR), established in 2001, is a population-based registry of voluntary twins. To date, it consists of approximately 29,000 twins who gave their consent to participate in the studies proposed by the ITR research group. The database comprises 11,500 monozygotic and 16,700 dizygotic twins resident throughout the country and belonging to a wide age range (from 0 to 95 years, mean 36.8 years). This article provides an overview of the recruitment strategies along with the major phenotypes investigated during an 18 years’ research period. Over the years, several self-reported questionnaire data were collected, together with saliva/blood samples and measurements taken during in-person interviews or outpatient clinical examinations. Mental and behavioral phenotypes as well as atherosclerotic traits were studied in depth across different age groups. A birth cohort of twins was established and followed up. Novel research hypotheses are also being tested in ongoing projects. The ITR is involved in international studies in collaboration with other twin registries and represents a valuable resource for national and international research initiatives regarding a broad spectrum of health-related characteristics.

An Update of Twin Research in Spain: The Murcia Twin Registry

2019 ◽  
Vol 22 (6) ◽  
pp. 667-671 ◽  
Author(s):  
Juan R. Ordoñana ◽  
Eduvigis Carrillo ◽  
Lucía Colodro-Conde ◽  
Francisco J. García-Palomo ◽  
Francisca González-Javier ◽  
...  
Keyword(s):  
Population Based ◽  
Short Term ◽  
Public Health Perspective ◽  
Twin Research ◽  
Main Research ◽  
Twin Registry ◽  
Adult Participants ◽  
Health Related ◽  
Population Based Registry

AbstractThe Murcia Twin Registry (MTR) is the only population-based registry in Spain. Created in 2006, the registry has been growing more than a decade to become one of the references for twin research in the Mediterranean region. The MTR database currently comprises 3545 adult participants born between 1940 and 1977. It also holds a recently launched satellite registry of university students (N = 204). Along five waves of data collection, the registry has gathered questionnaire and anthropometric data, as well as biological samples. The MTR keeps its main research focus on health and health-related behaviors from a public health perspective. This includes lifestyle, health promotion, quality of life or environmental conditions. Future short-term development points to the expansion of the biobank and the continuation of the collection of longitudinal data.

The Murcia Twin Registry: A Population-Based Registry of Adult Multiples in Spain

2012 ◽  
Vol 16 (1) ◽  
pp. 302-306 ◽  
Author(s):  
Juan R. Ordoñana ◽  
Irene Rebollo-Mesa ◽  
Eduvigis Carrillo ◽  
Lucía Colodro-Conde ◽  
Francisco J. García-Palomo ◽  
...  
Keyword(s):  
Development Strategy ◽  
Population Based ◽  
Short Term ◽  
Twin Registry ◽  
Health Related Behaviors ◽  
Health Related ◽  
Opposite Sex ◽  
The University ◽  
Population Based Registry

The Murcia Twin Registry (MTR) was created in 2006, under the auspices of the University of Murcia and the regional Health Authority, aiming to develop a research resource in Spain intended to stimulate current research and new investigation on the analysis of genetic factors related to health and health-related behaviors. The MTR development strategy was designed as a step-by-step process. Initially, it was focused on women's health but nowadays it includes males and opposite-sex twins. The database comprises 2,281 participants born between 1940 and 1966 in the region of Murcia, in Spain. There have been three waves of data collection and today the MTR databases include questionnaire and anthropometric data as well as biological samples. The current main areas of research interest are health and health-related behaviors, including lifestyle, health promotion, and quality of life. Future short-term development points to the completion of the biobank and continuing the collection of longitudinal data.

The Mid-Atlantic Twin Registry, Revisited

2012 ◽  
Vol 16 (1) ◽  
pp. 424-428 ◽  
Author(s):  
Emily C. H. Lilley ◽  
Judy L. Silberg
Keyword(s):  
South Carolina ◽  
Developmental Psychopathology ◽  
Human Microbiome ◽  
Population Based ◽  
Data Set ◽  
Twin Registry ◽  
Children Of Twins ◽  
Scientific Disciplines ◽  
Sleep Homeostasis ◽  
Population Based Registry

The Mid-Atlantic Twin Registry (MATR) is a population-based registry of more than 56,000 twins primarily born or living in Virginia, North Carolina, and South Carolina. The MATR employs several methods of ascertaining twins, and devotes considerable resources to tracking and maintaining communication with MATR participants. Researchers may utilize the MATR for administration of research services including study recruitment, collection of DNA, archival data set creation, as well as data collection through mailed, phone, or online surveys. In addition, the MATR houses the MATR Repository, with over 1,200 blood samples available for researchers interested in DNA genotyping. For over 35 years MATR twins have participated in research studies with investigators from diverse scientific disciplines and various institutions. These studies, which have resulted in numerous publications, have covered a range of topics, including the human microbiome, developmental psychopathology, depression, anxiety, substance use, epigenetics of aging, children of twins, pre-term birth, social attitudes, seizures, eating disorders, as well as sleep homeostasis. Researchers interested in utilizing twins are encouraged to contact the MATR to discuss potential research opportunities.

Colorado Twin Registry

2006 ◽  
Vol 9 (6) ◽  
pp. 941-949 ◽  
Author(s):  
Sally-Ann Rhea ◽  
Andy A. Gross ◽  
Brett C. Haberstick ◽  
Robin P. Corley
Keyword(s):  
Reading Ability ◽  
Behavioral Genetics ◽  
Early Reading ◽  
Population Based ◽  
Demographic Information ◽  
Early Reading Development ◽  
University Of Colorado ◽  
Executive Cognitive Function ◽  
Twin Registry ◽  
Population Based Registry

AbstractThe Colorado Twin Registry (CTR) is a population-based registry housed at the Institute for Behavioral Genetics, University of Colorado. Recruited subjects' birth years date from 1968. Four samples comprise the CTR: the Community Twin Sample, Infant Twin Sample, Longitudinal Twin Sample, and the Early Reading Development Sample. Criteria for enrollment, recruitment strategies, demographic information and zygosity assignment are explained for each sample. In addition, 8 studies in which CTR twins have participated are highlighted. These include studies of early cognition, early reading ability, executive cognitive function, and vulnerability to substance abuse and antisocial behavior. Goals, measures, and brief results are provided for each study. The development of the CTR is an ongoing and evolving process, and it has proved to be a valuable resource, relatively representative of the population from which it was drawn.

scholarly journals The hidden harms of using alcohol for pain relief in older adults

2014 ◽  
Vol 26 (11) ◽  
pp. 1929-1930 ◽  
Author(s):  
Kim-Michelle Gilson ◽  
Christina Bryant ◽  
Fiona Judd
Keyword(s):  
Older Adults ◽  
Blood Alcohol Concentration ◽  
Age Groups ◽  
Household Survey ◽  
Population Based ◽  
Alcohol Concentration ◽  
Fatty Tissue ◽  
National Household Survey ◽  
Increased Sensitivity ◽  
Age Range

Estimates from population-based studies indicate that older adults drink more frequently than younger age groups. Data from the 2010 Australian national household survey reported that daily drinking was evident in 13.3% of older adults aged 60–69 years and in 14.8% of older adults aged 70+ years. These findings are compared to daily drinking rates reported by 10.1% of adults aged 50–59 years and 7.5% in the 40–49 years age range (Australian Institute of Health and Welfare, 2011). The study of alcohol consumption in older adults is particularly important because of their increased sensitivity to alcohol-related harms. With age, the body's ability to process alcohol decreases as a result of physiological changes, such as decreases in body mass and higher levels of fatty tissue, leading to a higher blood alcohol concentration for a given dose compared with younger adults (National Institute on Alcohol Abuse and Alcoholism, 1998). This greater vulnerability to the effects of alcohol necessitates a stronger understanding of drinking practices in older adults.

Sick-Leave due to Psychiatric Disorder: Higher Incidence among Women and Longer Duration for Men

1996 ◽  
Vol 169 (6) ◽  
pp. 740-746 ◽  
Author(s):  
Gunnel Hensing ◽  
Kristina Alexanderson ◽  
Peter Allebeck ◽  
Per Bjurulf
Keyword(s):  
Gender Differences ◽  
Psychiatric Disorder ◽  
Sick Leave ◽  
Psychiatric Disorders ◽  
Age Groups ◽  
Quantitative Measure ◽  
Population Based ◽  
Working Capacity ◽  
Health Related ◽  
Minor Psychiatric Disorders

BackgroundWomen take sick-leave more often than men, both in general and because of psychiatric disorders. The aim of the present study was to introduce the new dimension of sick-leave duration in the analysis of gender differences in minor psychiatric disorders.MethodA population-based register was used which included all sick-leave spells exceeding seven consecutive days, 1985–1987, in a Swedish county.ResultsSick-leave duration was longer for men. The greatest gender differences were found in the youngest and oldest age-groups. Women had higher incidence also in the longest spells. An increase in duration over the three years was found among women, leading to decreased gender differences.ConclusionsContrary to other studies on minor psychiatric disorders, small gender differences were found. It is suggested that sick-leave duration can be used as a quantitative measure of health-related working capacity.

The Norwegian Twin Registry

2012 ◽  
Vol 15 (6) ◽  
pp. 775-780 ◽  
Author(s):  
Thomas S. Nilsen ◽  
Ingunn Brandt ◽  
Per Magnus ◽  
Jennifer R. Harris
Keyword(s):  
Public Health ◽  
Scientific Community ◽  
Twin Studies ◽  
Population Based ◽  
Twin Data ◽  
Related Research ◽  
Twin Registry ◽  
Broad Array ◽  
Health Related Research ◽  
Health Related

Norway has a long-standing tradition in twin research, but the data collected in several population-based twin studies were not coordinated centrally or easily accessible to the scientific community. In 2009, the Norwegian Twin Registry was established at the Norwegian Institute of Public Health (NIPH) in Oslo with the purpose of creating a single research resource for Norwegian twin data. As of today, the Norwegian Twin Registry contains 47,989 twins covering birth years 1895–1960 and 1967–1979; 31,440 of these twins consented to participate in health-related research. In addition, DNA from approximately 4,800 of the twins is banked at the NIPH biobank and new studies are continually adding new data to the registry. The value of the Norwegian twin data is greatly enhanced by the linkage opportunities offered by Norway's many nationwide registries, spanning a broad array of medical, demographic, and socioeconomic information.

scholarly journals Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017

2021 ◽  
Author(s):  
Chang Liu ◽  
Ying-Chao Yuan ◽  
Mo-Ning Guo ◽  
Zhong Xin ◽  
Guan-Jie Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Chinese Population ◽  
Age Groups ◽  
Population Based ◽  
Annual Incidence ◽  
Age Group ◽  
And Gender ◽  
Population Based Registry ◽  
Design And Methods

OBJECTIVE─ Previous reports of the annual incidence of type 1 diabetes (T1D) in China were conducted using retrospective hospital cases, which may not reflect the reality. This longitudinal study estimated T1D incidence in a 21.7-million Chinese population during 2007-2017. <p>RESEARCH DESIGN AND METHODS─ A population-based registry of T1D was performed by the Beijing Municipal Health Commission Information Center. Annual incidence and 95% confidence intervals (CI) were calculated by age group and gender. The association of gender with T1D incidence and predicted new T1D cases were assessed using Poisson regression models. Annual percentage change and average annual percentage of change were assessed using Joinpoint regression. </p> <p>RESULTS─ Overall, there were 6,875 individuals who developed T1D from 2007 to 2017 in this population. T1D incidence [95% CI] (/100,000 persons) significantly increased from 2.72 [2.51, 2.93] in 2007 to 3.60 [3.38, 3.78] in 2017 (p<0.001). The T1D onset peak was in the 10-14 age group. While no significant trend was found in the 0-14 and 15-29 age groups, T1D incidence markedly increased from 1.87 to 3.52 in ≥30 age group (p<0.05). The prevalence of diabetic ketoacidosis at diagnosis was highest in 0-4 age group. We predicted T1D new cases will increase to 1.57-fold over the next decade. </p> CONCLUSIONS─ T1D incidence in this large Chinese population is higher than has been reported previously. During 2007-2017, although the incidence peak was in the 10-14 age group, the T1D incidence increased sharply in adults but not in youth.

Abstract P254: Health-Related Internet Use in Patients with Hypertension: A Population-Based Analysis

2011 ◽  
Vol 4 (suppl_2) ◽  
Author(s):  
Joseph Finkelstein ◽  
Eunme Cha
Keyword(s):  
Health Status ◽  
Statistical Significance ◽  
Age Groups ◽  
Population Based ◽  
Sampling Weights ◽  
Logistic Regression Models ◽  
Income Ratio ◽  
Health Related ◽  
The Difference ◽  
The Impact

Background: With widely available web-based information about hypertension, internet has the potential to improve health literacy and to affect clinical outcomes. In this study we assessed the prevalence of health-related internet (HRI) usage by patients with hypertension and its association with health outcomes. Methods: Hypertension was defined by the question, “Have you ever been told by a doctor or health profession that you have high blood pressure?” Participants who answered “Yes” were included in the sample. If the participants stated that they accessed the Internet to look up health information, to learn about health topics in chat groups, to refill prescriptions, to schedule appointments, or to communicate with their provider, they were included in ‘HRI user’ group. Two logistic regression models were run to assess predictors of HRI usage and to explore the impact of HRI use on health status among hypertension patients. All models were controlled by age, gender, marital status, race, education, and poverty income ratio (PIR). Sampling weights were utilized to produce population-based results. Results: The prevalence of HRI use in hypertension patients was: 57% (40-55 yrs), 50% (56-65 yrs) and 26% (>65 yrs). In comparison, 58% (40-55 yrs), 56% (56-65 years) and 29% (>65 yrs) of population without hypertension used HRI. The difference between two groups was not statistically significant. Younger age (OR 4.0, p <.0001 for 40-55 group, and OR 2.6, p=0.001 for 50-65 group), women (OR 1.4, p <.0001), higher education (OR 3.8, p <.0001 for 12+ years of education), or higher PIR (OR 1.3, p=0.02 for PIR=2, and OR=3.1, p <.0001 for PIR>=3) were predictors of using HRI with statistical significance. Compared to Caucasians, Africans Americans (OR 0.5, p=0.04) were less likely to use the HRI. After adjusting for socio-demographic variables, patients who used HRI in the last 12 months were 1.3 time more likely to report improvement in health status (p=0.04). Conclusions: HRI usage between the hypertension patients and general population did not differ significantly in different age groups. Age, gender, education, PIR, and race were significant predictors of HRI usage pattern. HRI use was associated with improvement in health status within 12 months of using internet.

scholarly journals On Exploring Hidden Structures Behind Cervical Cancer Incidence

2018 ◽  
Vol 25 (1) ◽  
pp. 107327481880160 ◽  
Author(s):  
Niko Lietzén ◽  
Janne Pitkäniemi ◽  
Sirpa Heinävaara ◽  
Pauliina Ilmonen
Keyword(s):  
Cervical Cancer ◽  
Cancer Incidence ◽  
Age Groups ◽  
Population Based ◽  
Cervical Cancer Incidence ◽  
Disease Epidemiology ◽  
Age Dependent ◽  
Population Based Registry ◽  
Latent Components

Finding new etiological components is of great interest in disease epidemiology. We consider time series version of invariant coordinate selection (tICS) as an exploratory tool in the search of hidden structures in the analysis of population-based registry data. Increasing cancer burden inspired us to consider a case study of age-stratified cervical cancer incidence in Finland between the years 1953 and 2014. The latent components, which we uncover using tICS, show that the etiology of cervical cancer is age dependent. This is in line with recent findings related to the epidemiology of cervical cancer. Furthermore, we are able to explain most of the variation of cervical cancer incidence in different age groups by using only two latent tICS components. The second tICS component, in particular, is interesting since it separates the age groups into three distinct clusters. The factor that separates the three clusters is the median age of menopause occurrence.

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