The Norwegian Twin Registry

2012 ◽  
Vol 15 (6) ◽  
pp. 775-780 ◽  
Author(s):  
Thomas S. Nilsen ◽  
Ingunn Brandt ◽  
Per Magnus ◽  
Jennifer R. Harris
Keyword(s):  
Public Health ◽  
Scientific Community ◽  
Twin Studies ◽  
Population Based ◽  
Twin Data ◽  
Related Research ◽  
Twin Registry ◽  
Broad Array ◽  
Health Related Research ◽  
Health Related

Norway has a long-standing tradition in twin research, but the data collected in several population-based twin studies were not coordinated centrally or easily accessible to the scientific community. In 2009, the Norwegian Twin Registry was established at the Norwegian Institute of Public Health (NIPH) in Oslo with the purpose of creating a single research resource for Norwegian twin data. As of today, the Norwegian Twin Registry contains 47,989 twins covering birth years 1895–1960 and 1967–1979; 31,440 of these twins consented to participate in health-related research. In addition, DNA from approximately 4,800 of the twins is banked at the NIPH biobank and new studies are continually adding new data to the registry. The value of the Norwegian twin data is greatly enhanced by the linkage opportunities offered by Norway's many nationwide registries, spanning a broad array of medical, demographic, and socioeconomic information.

scholarly journals Comprehensive scoping review of health research using social media data

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e022931 ◽  
Author(s):  
Joanna Taylor ◽  
Claudia Pagliari
Keyword(s):  
Public Health ◽  
Social Media ◽  
Scoping Review ◽  
Ethical Issues ◽  
Social Media Data ◽  
Related Research ◽  
Health Related Research ◽  
Health Related ◽  
Google Search ◽  
Media Data

IntroductionThe rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews tend to be narrow in scope, with limited consideration of the different types of data, analytical methods and ethical issues involved. There has also been a tendency for research to be siloed within different academic communities (eg, computer science, public health), hindering knowledge translation. To address these limitations, we will undertake a comprehensive scoping review, to systematically capture the broad corpus of published, health-related research based on social media data. Here, we present the review protocol and the pilot analyses used to inform it.MethodsA version of Arksey and O’Malley’s five-stage scoping review framework will be followed: (1) identifying the research question; (2) identifying the relevant literature; (3) selecting the studies; (4) charting the data and (5) collating, summarising and reporting the results. To inform the search strategy, we developed an inclusive list of keyword combinations related to social media, health and relevant methodologies. The frequency and variability of terms were charted over time and cross referenced with significant events, such as the advent of Twitter. Five leading health, informatics, business and cross-disciplinary databases will be searched: PubMed, Scopus, Association of Computer Machinery, Institute of Electrical and Electronics Engineers and Applied Social Sciences Index and Abstracts, alongside the Google search engine. There will be no restriction by date.Ethics and disseminationThe review focuses on published research in the public domain therefore no ethics approval is required. The completed review will be submitted for publication to a peer-reviewed, interdisciplinary open access journal, and conferences on public health and digital research.

scholarly journals The Norwegian Institute of Public Health Twin Program of Research: An Update

2006 ◽  
Vol 9 (6) ◽  
pp. 858-864 ◽  
Author(s):  
Jennifer R. Harris ◽  
Per Magnus ◽  
Kristian Tambs
Keyword(s):  
Public Health ◽  
Large Population ◽  
Population Based ◽  
Twin Data ◽  
Twin Research ◽  
Physical Health Outcomes ◽  
Research Activities ◽  
Broad Array ◽  
Axis I ◽  
Large Effort

AbstractThe population-based twin program of research at the Norwegian Institute of Public Health (NIPH) was begun in 1992. It consists of a number of questionnaire and clinical interview projects exploring a broad array of mental and physical health outcomes. This article provides a brief update summarizing our research activities, some research highlights, new developments and potentials for further developing the program of twin research. In the most recent years a large effort has concentrated on completing a mental health interview study of Axis I psychiatric and substance use disorders and Axis II personality disorders. Although still in the early planning phases, one of the most significant developments is that an agreement is now in place to centralize the Norwegian twin data into a national Norwegian Twin Registry. This new registry will include twin cohorts born from 1905 onwards. Other resources for building twin projects are described. Nationally, there is great potential for linking the NIPH twin data with other health registries and with information in a number of Norway's large population-based biobank studies. Internationally, platforms such as those developed within GenomEUtwin, for data standards and data sharing and access are greatly facilitating international collaborations in twin research.

scholarly journals The Norwegian Twin Registry

2016 ◽  
Vol 26 (1-2) ◽  
Author(s):  
Thomas S. Nilsen ◽  
Ingunn Brandt ◽  
Nikolai Czajkowski ◽  
Peggy Knudsen ◽  
Per Magnus ◽  
...  
Keyword(s):  
Mental Health ◽  
Large Population ◽  
Twin Studies ◽  
Population Based ◽  
Twin Data ◽  
Twin Research ◽  
Health Lifestyle ◽  
Twin Registry ◽  
The 1960S ◽  
Access To Data

The Norwegian Twin Registry (NTR) is a large population based twin cohort for research purposes. At present,<br />the registry has 14 692 complete twin pairs with information on zygosity and to varying degree information on<br />somatic and mental health, lifestyle and demographics. The registry covers birth years 1895-1960 and 1967-<br />1991. NTR was established in 2009, at the Norwegian Institute of Public Health, as a merger of three major<br />twin panels, the oldest originating in the 1960s. Since then Norwegian twin research has been a notable<br />contributor to twin research internationally. Norwegian twin researchers have published over 250 papers based<br />on Norwegian twin data, spanning a broad range of somatic and mental health phenotypes. In twin studies of<br />heritability a data structure with both variance within and between pairs is required. Therefore a large sample is<br />necessary, especially when studying rare diseases and conditions, and it is of vital importance to expand the<br />registry. NTR is actively recruiting new twins, both young and older, but declining response rates are a<br />challenge. The value of NTR is greatly enhanced through the linkage possibilities offered by Norway’s many<br />nationwide registries (medical, demographic, and socio-economic). Access to data is permitted by the NTR<br />steering group and will in most instances need permission from the Regional Ethics Committee.

scholarly journals Internalization of Phospholipid-Coated Gold Nanoparticles

Crystals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 544
Author(s):  
Lindsay J. Shearer ◽  
Nils O. Petersen
Keyword(s):  
Gold Nanoparticles ◽  
A549 Cells ◽  
Cell Types ◽  
Endocytic Pathway ◽  
Cell Entry ◽  
Potential Drug ◽  
Cell Type ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Gold nanoparticles are used in health-related research; however, their effectiveness appears to depend on how well they are internalized and where they are destined to travel. Internalization in cells is efficient if the gold nanoparticles are biocompatible, where one possible pathway of cell entry and processing is clathrin-mediated endocytosis. In this work we studied the co-localization of phospholipid-coated gold nanoparticles (PCAuNPs) with markers of the endocytic pathway (Rab and LAMP-1 proteins) in C2C12 and A549 cells and found that the internalization was consistent with clathrin-mediated endocytosis and was cell type dependent. We further found that the time evolution of uptake and disposal of these PCAuNPs was similar for both cell types, but aggregation was more significant in A549 cells. Our results support the use of these PCAuNPs as models for potential drug delivery platforms.

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