The Fitness of the Human Zygote

1975 ◽  
Vol 7 (1) ◽  
pp. 1-4 ◽  
Author(s):  
William H. James

SummaryThe fitness of human zygotes depends on both biological and demographic parameters. Some of the demographic parameters are changing at present in this country and accurate estimates of them are not available but this imprecision has no great bearing on the estimate of fitness offered below.Of 100 human zygotes, now, in this country, it is estimated that embryonic and early fetal loss (before the end of the 3rd month) accounts for 44; induced abortion, 7; late fetal loss (after the 3rd month), 4; and mortality between birth and maturity, 1½. Of the remaining 43½ who reach maturity, it is estimated that 8 fail to reproduce, leaving 35½ who do reproduce.The standard error of this estimate must be large because of the large standard error of the estimate of the incidence of natural reproductive wastage from which it was derived.

2020 ◽  
pp. 153450842093780
Author(s):  
Joseph F. T. Nese ◽  
Akihito Kamata

Curriculum-based measurement of oral reading fluency (CBM-R) is widely used across the country as a quick measure of reading proficiency that also serves as a good predictor of comprehension and overall reading achievement, but has several practical and technical inadequacies, including a large standard error of measurement (SEM). Reducing the SEM of CBM-R scores has positive implications for educators using these measures to screen or monitor student growth. The purpose of this study was to compare the SEM of traditional CBM-R words correct per minute (WCPM) fluency scores and the conditional SEM (CSEM) of model-based WCPM estimates, particularly for students with or at risk of poor reading outcomes. We found (a) the average CSEM for the model-based WCPM estimates was substantially smaller than the reported SEMs of traditional CBM-R systems, especially for scores at/below the 25th percentile, and (b) a large proportion (84%) of sample scores, and an even larger proportion of scores at/below the 25th percentile (about 99%) had a smaller CSEM than the reported SEMs of traditional CBM-R systems.


1967 ◽  
Vol 7 (26) ◽  
pp. 213
Author(s):  
RJW Gartner ◽  
JG Morris ◽  
GR Clark

Data on plasma and liver vitamin A concentrations were obtained from 84 Hereford steers approximately two years of age and approximately 900 lb in body-weight. The animals were sampled from two experiments : 57 received high-grain rations low in carotene for 150 � 15 days, 27 received similar rations for 154 � 6 days. Plasma vitamin A levels in 18 animals were below 20 �g/100 ml, and these values were associated with hepatic levels of less than 10 �g/g. The regression of plasma vitamin A on the logarithm of liver vitamin A was significant (P<0.01) and the regression coefficients were not significantly different between experiments. The equation was y = -30.506 + 19.705 log x. This equation has only limited value for prediction over the whole range tested due to the large standard error (9.24) and the limited magnitude of the correlation coefficient (0.80).


1982 ◽  
Vol 72 (6) ◽  
pp. 548-554 ◽  
Author(s):  
C S Chung ◽  
R G Smith ◽  
P G Steinhoff ◽  
M P Mi
Keyword(s):  

Epidemiology ◽  
1996 ◽  
Vol 7 (5) ◽  
pp. 540-542 ◽  
Author(s):  
Claire Infante-Rivard ◽  
Robert Gauthier

2020 ◽  
Vol 7 ◽  
pp. 233339282094134
Author(s):  
James Studnicki ◽  
John W. Fisher ◽  
David C. Reardon ◽  
Christopher Craver ◽  
Tessa Longbons ◽  
...  

Introduction: The number and outcomes of pregnancies experienced by a woman are consequential determinants of her health status. However, there is no published research comparing the patterns of subsequent pregnancy outcomes following a live birth, natural fetal loss, or induced abortion. Objectives: The objective of this study was to describe the characteristic patterns of subsequent pregnancy outcomes evolving from each of three initiating outcome events (birth, induced abortion, natural fetal loss) occurring in a Medicaid population fully insured for all reproductive health services. Methods: We identified 7,388,842 pregnancy outcomes occurring to Medicaid-eligible women in the 17 states which paid for abortion services between 1999-2014. The first known pregnancy outcome for each woman was marked as the index outcome which assigned each woman to one of three cohorts. All subsequent outcomes occurring up to the fifth known pregnancy were identified. Analyses of the three index outcome cohorts were conducted separately for all pregnancy outcomes, three age bands (<17, 17-35, 36+), and three race/ethnicity groups (Hispanic, Black, White). Results: Women with index abortions experienced more lifetime pregnancies than women with index births or natural fetal losses and were increasingly more likely to experience another pregnancy with each subsequent pregnancy. Women whose index pregnancy ended in abortion were also increasingly more likely to experience another abortion at each subsequent pregnancy. Both births and natural fetal losses were likely to result in a subsequent birth, rather than abortion. Women with natural losses were increasingly more likely to have a subsequent birth than women with an index birth. All age and racial/ethnic groups exhibited the characteristic pattern we have described for all pregnancy outcomes: abortion is associated with more subsequent pregnancies and abortions; births and fetal losses are associated with subsequent births. Other differences between groups are, however, apparent. Age is positively associated with the likelihood of a birth following an index birth, but negatively associated with the likelihood of a birth following an index abortion. Hispanic women are always more likely to have a birth and less likely to have an abortion than Black or White women, for all combinations of index outcome and the number of subsequent pregnancies. Similarly, Black women are always more likely to have an abortion and less likely to experience a birth than Hispanic or White women. Conclusion: Women experiencing repeated pregnancies and subsequent abortions following an index abortion are subjected to an increased exposure to hemorrhage and infection, the major causes of maternal mortality, and other adverse consequences resulting from multiple separation events.


Toxins ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 404 ◽  
Author(s):  
Hyunjung Baek ◽  
HyeJin Yang ◽  
Jong Hoon Lee ◽  
Na-Hoon Kang ◽  
Jinwook Lee ◽  
...  

Spontaneous abortion represents a common form of embryonic loss caused by early pregnancy failure. In the present study, we investigated the prophylactic effects of bee venom phospholipase A2 (bvPLA2), a regulatory T cell (Treg) inducer, on a lipopolysaccharide (LPS)-induced abortion mouse model. Fetal loss, including viable implants, the fetal resorption rate, and the fetal weight, were measured after LPS and bvPLA2 treatment. The levels of serum and tissue inflammatory cytokines were determined. To investigate the involvement of the Treg population in bvPLA2-mediated protection against fetal loss, the effect of Treg depletion was evaluated following bvPLA2 and LPS treatment. The results clearly revealed that bvPLA2 can prevent fetal loss accompanied by growth restriction in the remaining viable fetus. When the LPS-induced abortion mice were treated with bvPLA2, Treg cells were significantly increased compared with those in the non-pregnant, PBS, and LPS groups. After LPS injection, the levels of proinflammatory cytokines were markedly increased compared with those in the PBS mouse group, while bvPLA2 treatment showed significantly decreased TNF-α and IFN-γ expression compared with that in the LPS group. The protective effects of bvPLA2 treatment were not detected in Treg-depleted abortion-prone mice. These findings suggest that bvPLA2 has protective effects in the LPS-induced abortion mouse model by regulating Treg populations.


1987 ◽  
Vol 9 (3) ◽  
pp. 195-202 ◽  
Author(s):  
David B. Acker ◽  
Benjamin P. Sachs ◽  
Bernard J. Ransil ◽  
Emanuel A. Friedman

In the population of 563 normal live births, subject to the selection criteria of this study, the mean ultrasonographically-estimated fetal weight calculated using the Birnholz equation accurately predicts the mean true birth weight with less than 1 percent error. However, on a pairwise basis, the error was found to be systematic (rather than random) with a large standard error of the estimate (± 300 g). The equation consistently underestimated the mean birth weight between 1500–3750 g and consistently overestimated it thereafter.


1978 ◽  
Vol 48 ◽  
pp. 155-166 ◽  
Author(s):  
A. N. Argue ◽  
E. D. Clements ◽  
G. M. Harvey ◽  
C. A. Murray

SummaryAGK3-based optical positions are presented for 38 counterparts of radio sources selected from the catalogue of Elsmore &amp; Ryle. The measurements were made from plates taken with the 13-inch Astrograph, the 26-inch refractor and the 2.5 m (INT) reflector at Herstmonceux, and the 17-inch Schmidt at Cambridge. The standard error for a mean position of unit weight is 0”.11, and the weights range from 3.0 for the brightest sources to 0.5 for the faintest. Comparison with the radio positions shows no significant differences. The effects of applying the Brorfelde corrections to AGK3 are discussed.


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