Clinical usefulness of catheter-drawn blood samples and catheter-tip cultures for the diagnosis of catheter-related bloodstream infections in neonates

2020 ◽  
Vol 41 (7) ◽  
pp. 854-856
Author(s):  
Janita Ferreira ◽  
Paulo Augusto Moreira Camargos ◽  
Viviane Rosado ◽  
Leni Márcia Anchieta ◽  
Roberta Maia de Castro Romanelli
Keyword(s):  
Adverse Events ◽  
Bloodstream Infection ◽  
Efficient Method ◽  
Bloodstream Infections ◽  
Central Venous Catheters ◽  
Blood Sampling ◽  
Central Venous ◽  
Blood Samples ◽  
Catheter Tip ◽  
Catheter Related Bloodstream Infection

AbstractCatheter-drawn blood sampling is an efficient method of diagnosing catheter-related bloodstream infection (CRBSI) in neonates; it has greater sensitivity and accuracy than methods using catheter-tip cultures. No association was detected between catheter-drawn blood sampling and the occurrence of adverse events with central venous catheters.

scholarly journals Tsukamurella catheter-related bloodstream infection in a pediatric patient with pulmonary hypertension

2010 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Kristen A. Wendorf ◽  
Claudia M. Espinosa ◽  
William D. LeBar ◽  
Jason B. Weinberg
Keyword(s):  
Pulmonary Hypertension ◽  
Bloodstream Infection ◽  
Pediatric Patient ◽  
Bloodstream Infections ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Catheter Related Bloodstream Infection ◽  
Immunocompetent Patients

Catheter-related bloodstream infections (CR-BSI) are important complications in patients with long-term indwelling central venous catheters. In this report, we present the case of a 14-year-old male with pulmonary hypertension treated with continuous treprostinil infusion, who presented with a CR-BSI caused by a Tsukamurella species. This case highlights the potential for this unusual organism to cause infection in immunocompetent patients.

Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial

2004 ◽  
Vol 22 (15) ◽  
pp. 3163-3171 ◽  
Author(s):  
Hend Hanna ◽  
Robert Benjamin ◽  
Ioannis Chatzinikolaou ◽  
Badie Alakech ◽  
Deborah Richardson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cancer Patients ◽  
Bloodstream Infection ◽  
Tertiary Care ◽  
Bloodstream Infections ◽  
Central Venous Catheters ◽  
Care Hospital ◽  
Central Venous ◽  
Catheter Related Bloodstream Infection

PurposeTo evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections.Patients and MethodsThis prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy.ResultsBetween September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (± standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 ± 30.88 v 63.01 ± 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters.ConclusionLong-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.

Cohort Study of the Pathogenesis and Molecular Epidemiology of Catheter-Related Bloodstream Infection in Neonates With Peripherally Inserted Central Venous Catheters

2008 ◽  
Vol 29 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Jeffery S. Garland ◽  
Colleen P. Alex ◽  
Jackie M. Sevallius ◽  
Dawn M. Murphy ◽  
Mary J. Good ◽  
...  
Keyword(s):  
Cohort Study ◽  
Bloodstream Infection ◽  
Neonatal Intensive Care ◽  
Insertion Site ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Coagulase Negative Staphylococci ◽  
Pulsed Field Electrophoresis ◽  
Catheter Tip ◽  
Catheter Related Bloodstream Infection

Objective.To better define the pathogenesis of catheter-related bloodstream infection (BSI) in neonates with peripherally inserted central venous catheters (PICCs) to guide the development of more effective strategies for prevention.Design.Prospective nested cohort study.Setting.Level III neonatal intensive care unit in a community hospital.Methods.During a randomized trial to assess the safety and efficacy of a prophylactic vancomycin-heparin catheter-lock solution for the prevention of catheter-related BSI in neonates with PICCs, we performed cultures of peripheral and catheter-drawn blood samples, and quantitative cultures of catheter hub samples if BSI was suspected clinically. We performed semiquantitative cultures of the catheter tip and the catheter hub and the skin at the insertion site when the catheter was removed. Molecular subtyping by pulsed-field electrophoresis was used to determine the probable pathogenesis of all BSIs due to coagulase-negative staphylococci (CoNS); for BSIs caused by other microorganisms, epidemiologic concordance was based on speciation and antibiograms. Catheter-related BSI was considered extraluminally acquired if concordance was demonstrable solely between isolates recovered from the catheter tip and the blood, independent of concordance with isolates recovered from the insertion site. Catheter-related BSI was considered intraluminally acquired if concordance was demonstrated only between isolates recovered from the catheter hub and the blood. The source of the infection was considered indeterminate if both concordance patterns were present.Results.Nosocomial BSI was identified in 23 of the 82 neonates in the cohort. Fifteen of these infections, 14 of which were caused by CoNS, were considered definite or probable catheter-related BSIs. Catheter-related BSI was intraluminally acquired in 10 (67%) of 15 patients, extraluminally acquired in 3 (20%), and indeterminate in 2 (13%).Conclusions.Most catheter-related BSIs in neonates with PICCs are caused by CoNS and derive from intraluminal contamination. Strategies for prevention of catheter-related BSI directed at this predominant mechanism of infection are most likely to be effective.

scholarly journals Antimicrobial Impregnated Catheters in the Prevention of Catheter-Related Bloodstream Infection in Hospitalized Patients

2007 ◽  
Vol 12 (2) ◽  
pp. 77-90
Author(s):  
Sarah K. Wassil ◽  
Catherine M. Crill ◽  
Stephanie J. Phelps
Keyword(s):  
Bloodstream Infection ◽  
Bloodstream Infections ◽  
Central Venous Catheters ◽  
Hospitalized Patients ◽  
Central Venous ◽  
Related Factors ◽  
Future Directions ◽  
The Cost ◽  
Care Costs ◽  
Catheter Related Bloodstream Infection

Catheter-related bloodstream infections have a significant impact on increasing health care costs and morbidity and mortality in hospitalized patients. Many technologies have been created in an attempt to decrease the incidence of catheter-related bloodstream infection. One of these is the impregnation of central venous catheters with antiseptics (e.g., chlorhexidine and silver sulfadiazine) or antibiotics (e.g., minocycline and rifampin). While studies evaluating the efficacy of impregnated catheters have been conducted, the data are limited and their use remains variable across institutions. This paper will discuss catheter-related factors that predispose patients to catheter-related bloodstream infection, the types of antimicrobial-impregnated catheters in use today, studies evaluating their efficacy, and common concerns associated with the use of these catheters. Issues related to the cost-effectiveness of impregnated catheters and future directions for the prevention of catheter-related bloodstream infection will also be presented.

Prospective Incidence Study of Bloodstream Infection in Infants and Children With Central Venous Catheters After Cardiac Surgery in Italy

2009 ◽  
Vol 30 (7) ◽  
pp. 698-701 ◽  
Author(s):  
Stefania Bezzio ◽  
C. Scolfaro ◽  
R. Broglia ◽  
R. Calabrese ◽  
F. Mignone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Observational Study ◽  
Bloodstream Infection ◽  
Medical Staff ◽  
Prospective Observational Study ◽  
Central Venous Catheters ◽  
Central Venous ◽  
In Infants And Children ◽  
Catheter Related Bloodstream Infection

This prospective observational study was designed to assess the incidence of, risk factors for, and outcome of catheter-related bloodstream infection in children undergoing cardiac surgery. A staff specifically trained to handle the central venous catheters with proper aseptic techniques and an appropriate patient to medical staff ratio remain the most effective measures to prevent this infection.

Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection

2003 ◽  
Vol 31 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Marco Ranucci ◽  
Giuseppe Isgrò ◽  
Pier Paolo Giomarelli ◽  
Marco Pavesi ◽  
Aldo Luzzani ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Central Venous Catheters ◽  
Catheter Colonization ◽  
Central Venous ◽  
Catheter Related Bloodstream Infection

scholarly journals Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Michael Koeppen ◽  
Franziska Weinert ◽  
Sabrina Oehlschlaeger ◽  
Andreas Koerner ◽  
Peter Rosenberger ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bloodstream Infection ◽  
Bacterial Growth ◽  
Bacterial Contamination ◽  
Controlled Trial ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Catheter Related Bloodstream Infection

Abstract Background In the critically ill, catheter-related bloodstream infection can result from bacterial contamination of infusion hubs of intravascular catheters. Needle-free connectors (NFC) have been suggested to reduce the rate of bacterial contamination and subsequent catheter-related bloodstream infection (CRBSI), but data remains ambiguous. Thus, we tested if a novel NFC would reduce bacterial contamination and subsequent CRBSI. Results In a prospective, randomized controlled trial, surgical ICU patients were randomized to three-way hubs closed by caps or Bionecteur® (Vygon, Inc.) of central venous catheters. Every 72 h, infusion lines were renewed and microbiological samples were taken. Bacterial growth was analyzed by blinded microbiologists. Incidence of bacterial contamination and CRSBI were assessed. Outcome parameters like length of stay on ICU and outcome were retrospectively assessed. Two thousand seven hundred patients were screened, 111 were randomized to the NFC, and 109 into the control group. Finally, 24 patients in the NFC and 23 control patients were analyzed. The majority of samples (NFC 77%; control 70%) found no bacterial growth. Coagulase-negative staphylococci were most commonly detected on CVC samples (NFC 17%; control 21%). We found CRBSI (defined as identical pathogens in blood culture and catheter line tip culture, and clinical manifestations of infection) in two control patients and one patient of the NFC group. Their length of ICU stay did not differ between groups (NFC 19 days; control 23 days). Conclusion The use of NFC does not influence the rate of bacterial contamination of infusion hubs of central venous catheters. Trial registration Clinicaltrials.gov, NCT02134769. Registered 09 May 2014.

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