scholarly journals 2003 Mixed meal effects of neprilysin inhibition

2018 ◽  
Vol 2 (S1) ◽  
pp. 44-44
Author(s):  
Jessica R. Wilson ◽  
Daniel Rader ◽  
Raymond Townsend ◽  
Michael Rickels
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Mixed Meal ◽  
Diabetes Therapy ◽  
Study Population ◽  
Neprilysin Inhibition

OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1.

scholarly journals An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Miira Klemetti ◽  
Leena M. Hiltunen ◽  
Sanna Heino ◽  
Seppo Heinonen ◽  
Eero Kajantie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Elevated Blood ◽  
Study Population ◽  
Normotensive Pregnancy ◽  
Finnish Study ◽  
Risk Of Preeclampsia

Previous studies have demonstrated a common variant of the obesity and fat mass-relatedFTOgene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether theFTOSNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P=0.199). We found no evidence of an association between theFTOSNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.Erratum to “An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population”

scholarly journals The significance of some anthropometric parameters and parameters ensuing from them in assessing cardiovascular risk in type 2 diabetes

2006 ◽  
Vol 59 (1-2) ◽  
pp. 67-71
Author(s):  
Aniko Katona-Djurekovic ◽  
Edita Stokic
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Hdl Cholesterol ◽  
Elevated Blood Pressure ◽  
Diabetic Patients ◽  
Elevated Blood ◽  
Anthropometric Parameters ◽  
Type 2 Diabetics ◽  
Conicity Index

Introduction. Current clinical practice requires simple and available tools for cardiovascular risk assessment in diabetic patients. Material and methods. This study included 290 type 2 diabetics of both sexes. The following anthropometric parameters were measured: body mass index, waist circumference, sagital abdominal diameter, while ensuing parameters included: waist-to-stature ratio(WSH), ratio of abdominal sagital diameter to height (SADE), and conicity index. Metabolic status was evaluated based on lipidograms and HbAlc, and of cardiovascular parameters blood pressure was measured. Results. Female patients were obese, with central accumulation of fat, elevated blood pressure and lipid disorders such as hypo-HDL cholesterolemia. The applied anthropometric parameters and indicators ensuing from them (WSH, SADH and conicity index), are reliable indicators of elevated blood pressure in diabetic patients. Conclusion. The obtained results showed negative correlation with HDL cholesterol in women, which indirectly indicates to development of hypertension, as one of the most common diabetic complications. Central accumulation of fat with dyslipidemic disorder, characteristic of metabolic syndrome, is of highest importance. Sagital abdominal diameter (SAD) and WSH showed the highest correlation with lipidograms in females, whereas BMI was the best indicator in males. .

scholarly journals Association of Alcohol Intake With Hypertension in Type 2 Diabetes Mellitus: The ACCORD Trial

2020 ◽  
Vol 9 (18) ◽  
Author(s):  
Jonathan J. Mayl ◽  
Charles A. German ◽  
Alain G. Bertoni ◽  
Bharathi Upadhya ◽  
Prashant D. Bhave ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Alcohol Consumption ◽  
Elevated Blood Pressure ◽  
Moderate Alcohol Consumption ◽  
Elevated Blood ◽  
Pressure Stage ◽  
Heavy Alcohol Consumption ◽  
Stage 1

Background Heavy alcohol consumption has a well‐established association with hypertension. However, doubt persists whether moderate alcohol consumption has a similar link. This relationship is not well‐studied in patients with diabetes mellitus. We aimed to describe the association of alcohol consumption with prevalent hypertension in participants in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) trial. Methods and Results Alcohol consumption was categorized as none, light (1–7 drinks/week), moderate (8–14 drinks/week), and heavy (≥15 drinks/week). Blood pressure was categorized using American College of Cardiology/American Heart Association guidelines as normal, elevated blood pressure, stage 1 hypertension, and stage 2 hypertension. Multivariable logistic regression was used to explore the association between alcohol consumption and prevalent hypertension. A total of 10 200 eligible participants were analyzed. Light alcohol consumption was not associated with elevated blood pressure or any stage hypertension. Moderate alcohol consumption was associated with elevated blood pressure, stage 1, and stage 2 hypertension (odds ratio [OR], 1.79; 95% CI, 1.04–3.11, P =0.03; OR, 1.66; 95% CI, 1.05–2.60, P =0.03; and OR, 1.62; 95% CI, 1.03–2.54, P =0.03, respectively). Heavy alcohol consumption was associated with elevated blood pressure, stage 1, and stage 2 hypertension (OR, 1.91; 95% CI, 1.17–3.12, P =0.01; OR, 2.49; 95% CI, 1.03–6.17, P =0.03; and OR, 3.04; 95% CI, 1.28–7.22, P =0.01, respectively). Conclusions Despite prior research, our findings show moderate alcohol consumption is associated with hypertension in patients with type 2 diabetes mellitus and elevated cardiovascular risk. We also note a dose‐risk relationship with the amount of alcohol consumed and the degree of hypertension.

scholarly journals Low-Dose Candesartan Cilexetil Prevents Early Kidney Damage in Type 2 Diabetic Patients with Mildly Elevated Blood Pressure.

2003 ◽  
Vol 26 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Satoru MURAYAMA ◽  
Tsutomu HIRANO ◽  
Taro SAKAUE ◽  
Kenta OKADA ◽  
Reiko IKEJIRI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Low Dose ◽  
Candesartan Cilexetil ◽  
Kidney Damage ◽  
Elevated Blood Pressure ◽  
Diabetic Patients ◽  
Elevated Blood ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals The Prevalence of Metabolic Syndrome and Its Components among People with Type 2 Diabetes in the Ho Municipality, Ghana: A Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
James Osei-Yeboah ◽  
William K. B. A. Owiredu ◽  
Gameli Kwame Norgbe ◽  
Sylvester Yao Lokpo ◽  
Jones Gyamfi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
High Blood Pressure ◽  
Abdominal Obesity ◽  
Principal Component ◽  
Cross Sectional ◽  
Predominant Component ◽  
Study Population

The cooccurrence of diabetes mellitus and metabolic syndrome potentiates the cardiovascular risk associated with each of the conditions; therefore characterizing metabolic syndrome among people with type 2 diabetes is beneficial for the purpose of cardiovascular disease prevention. This study aims at evaluating the prevalence of metabolic syndrome and its components among 162 patients with type 2 diabetes attending the diabetic clinic of the Ho Municipal Hospital, Ghana. Data obtained included anthropometric indices, blood pressure, serum lipids, glucose, and sociodemographics and clinical information. The overall prevalence of metabolic syndrome among the study population was 43.83%, 63.58%, and 69.14% using the NCEP-ATP III, the WHO, and the IDF criteria, respectively. The most predominant component among the study population was high blood pressure using the NCEP-ATP III (108 (66.67%)) and WHO (102 (62.96)) criteria and abdominal obesity (112 (69.14%)) for IDF criteria. High blood pressure was the most prevalent component among the males while abdominal obesity was the principal component among the females. In this population with type 2 diabetes, high prevalence of metabolic syndrome exists. Gender vulnerability to metabolic syndrome and multiple cluster components were skewed towards the female subpopulation with type 2 diabetes.

Abstract P018: The Angiotensin Type 2 Receptor (AT 2 R) Is Involved In The Etiology Of Inverse Salt Sensitivity Of Blood Pressure

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Peng Xu ◽  
Kwabena Sarpong ◽  
John J Gildea ◽  
Stephen Marshall ◽  
Wei Yue ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Membrane ◽  
Salt Sensitivity ◽  
T Test ◽  
Elevated Blood Pressure ◽  
Sodium Reabsorption ◽  
Elevated Blood ◽  
Salt Diet ◽  
Angiotensin Type 2 Receptor

Renal proximal tubule (RPT) dopamine D 1 -like receptors (D 1 R) and angiotensin II type-2 receptor (AT 2 R) inhibit sodium reabsorption and counter regulate the renin angiotensin systems AT 1 R which stimulates sodium reabsorption. Salt sensitivity of blood pressure (SS) is defined as a ≥7-mmHg rise in blood pressure following a week of daily consumption of 350 mM sodium chloride (NaCl). Inverse salt sensitivity (ISS) is defined as a ≥7-mm Hg increase in blood pressure (BP) after a week of 10 mM NaCl/day. Salt resistant controls were defined as < 7mM Hg change in BP whether on 10 or 350mmHg NaCl/day for one week. Previously, we demonstrated that D 1 R RPT membrane recruitment was inversely proportional to an individual’s degree of BP increase on a 350 mM diet. We hypothesize that the degree of salt sensitivity of blood pressure would be inversely correlated with the recruitment of the AT 2 R to the plasma membrane induced by NaCl. Immunostaining shows that D 1 R was distributed in a fine granular manner throughout the whole plasma membrane, while AT 2 R shows a punctate pattern in both urine-derived SR and ISS RPTCs. There was no difference of basal D 1 R or AT 2 R expression. Increasing cell NaCl (monensin ionophore 10 μM, 1 hour) resulted in a significantly more AT 2 R and D 1 R(control) recruitment to cell surface in ISS cells than in SR cells (D 1 R: MON/VEH: SR, 1.032 ± 0.056, n=4; ISS, 1.537 ± 0.097, n=4; t-test, p<0.01; AT 2 R :MON/VEH: SR, 0.923 ± 0.063, n=3; ISS, 1.28 ± 0.106, n=3; t-test, p<0.05). Because ISS individuals present to the medical system with elevated blood pressure while on a low salt diet, they are often misdiagnosed as hypertensive. As our studies were conducted on RPT cells isolated from individual's urine, the D 1 R and AT 2 R response may contribute to the diagnosis of ISS individuals with elevated blood pressure while on a 10 mM salt diet, and provide better understanding on the etiology of ISS.

scholarly journals Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor

2004 ◽  
Vol 89 (3) ◽  
pp. 313-322 ◽  
Author(s):  
HongWei Wang ◽  
Stefan Gallinat ◽  
Hong-wei Li ◽  
Colin Sumners ◽  
Mohan K. Raizada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type
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