scholarly journals An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Miira Klemetti ◽  
Leena M. Hiltunen ◽  
Sanna Heino ◽  
Seppo Heinonen ◽  
Eero Kajantie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Elevated Blood ◽  
Study Population ◽  
Normotensive Pregnancy ◽  
Finnish Study ◽  
Risk Of Preeclampsia

Previous studies have demonstrated a common variant of the obesity and fat mass-relatedFTOgene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether theFTOSNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P=0.199). We found no evidence of an association between theFTOSNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.Erratum to “An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population”

scholarly journals 2003 Mixed meal effects of neprilysin inhibition

2018 ◽  
Vol 2 (S1) ◽  
pp. 44-44
Author(s):  
Jessica R. Wilson ◽  
Daniel Rader ◽  
Raymond Townsend ◽  
Michael Rickels
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Mixed Meal ◽  
Diabetes Therapy ◽  
Study Population ◽  
Neprilysin Inhibition

OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1.

scholarly journals 5.1 The Role of Blood Pressure, Aortic Stiffness, and Haemodynamics in Brain Health in Older People with Type 2 Diabetes Mellitus

2020 ◽  
Vol 25 (Supplement 1) ◽  
pp. S37
Author(s):  
Christopher Karayiannis ◽  
Chris Moran ◽  
Richard Beare ◽  
James Sharman ◽  
Thanh Phan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Aortic Stiffness ◽  
Brain Health

scholarly journals Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ganesh Chauhan ◽  
Ismeet Kaur ◽  
Rubina Tabassum ◽  
Om Prakash Dwivedi ◽  
Saurabh Ghosh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Cardiovascular Disorder ◽  
Common Variants ◽  
Study Population ◽  
North Indians ◽  
Sample Set

Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variantMTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR=0.78(95%  CI=0.67–0.92),P=0.003) and was also associated with 2 h postload plasma glucose (P=0.04), high-density lipoprotein cholesterol (P=0.004), and total cholesterol (P=0.01) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits.

scholarly journals P4-343: THE ROLE OF BLOOD PRESSURE, AORTIC STIFFNESS, AND HAEMODYNAMICS IN BRAIN HEALTH IN OLDER PEOPLE WITH TYPE 2 DIABETES MELLITUS

2019 ◽  
Vol 15 ◽  
pp. P1428-P1429
Author(s):  
Christopher C. Karayiannis ◽  
Chris Moran ◽  
Richard Beare ◽  
James Sharman ◽  
Thanh G. Phan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Aortic Stiffness ◽  
Brain Health

scholarly journals The role of natural supplement of apple vinegar and syrup in the management of type 2 diabetes mellitus

2014 ◽  
Vol 4 (3) ◽  
pp. 176-180 ◽  
Author(s):  
Bećir Heljić ◽  
Zelija Velija-Ašimi ◽  
Azra Bureković ◽  
Vanja Karlović ◽  
Azra Avdagić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein

Introduction: The increased risk of coronary artery disease in diabetics could be explained by the lipoprotein irregularities associated with diabetes mellitus. The primary aim of this study is to examine the role of apple vinegar and syrup in the management of type 2 diabetes mellitus.Methods: The interventional study included 500 participants (195 men and 305 women) with dyslipidemia and prediabetes or type 2 diabetes mellitus, aged 50-70 years, living in Sarajevo area. Patients were recruited from 5 outpatient diabetes counselling departments and treated with natural apple vinegar and syrup supplementation over a period of five weeks. The patients have been evaluated before treatment and 5 weeks after the treatment. During the study, dosage of drugs for diabetes or prediabetes was not changed.Results: After 5 weeks of supplementation with apple vinegar and syrup waist circumference (p=0.016), total cholesterol (p=0.01), low density lipoprotein (LDL) cholesterol (p=0.008) and triglycerides (p=0.019) were significantly reduced, as well as blood pressure (-14%). Study results show decrease of mean fasting blood levels of glucose, but statistically not significant (p=0.058). The body mass index also decreased insignificantly (p=0.089). The high density lipoprotein cholesterol level was not increased significantly after supplementation (p=0.26).Conclusion: According to our results, apple vinegar has important role in reduction of total cholesterol levels, triglycerides, LDL cholesterol and waist circumference in patients with type 2 diabetes. Also, it has positive effect on blood pressure.

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