scholarly journals Low-Dose Candesartan Cilexetil Prevents Early Kidney Damage in Type 2 Diabetic Patients with Mildly Elevated Blood Pressure.

2003 ◽  
Vol 26 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Satoru MURAYAMA ◽  
Tsutomu HIRANO ◽  
Taro SAKAUE ◽  
Kenta OKADA ◽  
Reiko IKEJIRI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Low Dose ◽  
Candesartan Cilexetil ◽  
Kidney Damage ◽  
Elevated Blood Pressure ◽  
Diabetic Patients ◽  
Elevated Blood ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients

2007 ◽  
Vol 292 (1) ◽  
pp. E347-E352 ◽  
Author(s):  
Marina Cardellini ◽  
Maria Adelaide Marini ◽  
Simona Frontoni ◽  
Marta Letizia Hribal ◽  
Francesco Andreozzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Cell ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Glucose Disposal ◽  
Diabetic Patients ◽  
Blood Cell Count ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

The aim of this study was to investigate whether insulin resistance is independently associated with early manifestations of atherosclerosis. To this end, 176 normotensive offspring of type 2 diabetic patients were subjected to euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Early atherosclerosis was studied by ultrasonography of the common carotid artery. Of the total 176 subjects, 145 were glucose tolerant, 18 had impaired fasting glucose, and 13 had impaired glucose tolerance. Univariate correlations showed that age, body mass index, waist, blood pressure, 2-h postchallenge glucose, fasting insulin, triglycerides, interleukin-6, fibrinogen, and white blood cell count were significantly correlated with carotid intima-media thickness (IMT), whereas HDL cholesterol and glucose disposal showed a negative correlation. A stepwise multivariate regression analysis including sex, age, waist circumference, smoking status, systolic blood pressure, diastolic blood pressure, triglyceride, HDL cholesterol, 2-h postchallenge glucose, plasma IL-6, fibrinogen, white blood cell count, insulin-stimulated glucose disposal, and fasting insulin showed that the four variables that remained significantly associated with carotid IMT were waist circumference, insulin-stimulated glucose disposal, white blood cell count, and diastolic blood pressure, accounting for 33.7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document