Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups

2012 ◽  
Vol 2012 ◽  
pp. 179-180
Author(s):  
G.K. Kim ◽  
J.Q. Del Rosso
Keyword(s):  
Iron Deficiency ◽  
Hair Loss ◽  
Control Groups ◽  
Female Pattern Hair Loss ◽  
And Control

Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups

2010 ◽  
Vol 63 (6) ◽  
pp. 991-999 ◽  
Author(s):  
Elise A. Olsen ◽  
Katherine B. Reed ◽  
Patrick B. Cacchio ◽  
Leslie Caudill
Keyword(s):  
Iron Deficiency ◽  
Hair Loss ◽  
Control Groups ◽  
Female Pattern Hair Loss ◽  
And Control

scholarly journals H. pyloriMay Not Be Associated with Iron Deficiency Anemia in Patients with Normal Gastrointestinal Tract Endoscopy Results

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Tayyibe Saler ◽  
Şakir Özgür Keşkek ◽  
Sibel Kırk ◽  
Süleyman Ahbab ◽  
Gülay Ortoğlu
Keyword(s):  
Gastrointestinal Tract ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Male Patients ◽  
H Pylori ◽  
And Control

Background. The aim of this study was to investigate the association between iron deficiency anemia andH. pyloriin patients with normal gastrointestinal tract endoscopy results.Materials and Methods. A total of 117 male patients with normal gastrointestinal tract endoscopy results were included in this retrospective study. The study and control groups included 69 and 48 patients with and without iron deficiency anemia, respectively. The prevalence ofH. pylori, the number of RBCs, and the levels of HGB, HTC, MCV, iron, and ferritin were calculated and compared.Results. There was no statistically significant difference found between the groups according to the prevalence ofH. pylori(65.2% versus 64.6%,P=0.896). Additionally, the levels of RBCs, HGB, HTC, MCV, iron, and ferritin in the patients in the study group were lower than those in the control group (P<0.05). Finally, there was no association between iron deficiency anemia andH. pylori(OR 1.02, Cl 95% 0.47–2.22, andP=0.943).Conclusion.H. pyloriis not associated with iron deficiency anemia in male patients with normal gastrointestinal tract endoscopy results.

scholarly journals A Randomized Feeding Trial of Iron-Biofortified Beans on School Children in Mexico

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 381 ◽  
Author(s):  
Julia Finkelstein ◽  
Saurabh Mehta ◽  
Salvador Villalpando ◽  
Veronica Mundo-Rosas ◽  
Sarah Luna ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Status ◽  
Efficacy Trial ◽  
Feeding Trial ◽  
Control Groups ◽  
Body Iron ◽  
Total Body ◽  
Cluster Randomized ◽  
And Control

Iron deficiency is a major public health problem worldwide, with the highest burden among children. The objective of this randomized efficacy feeding trial was to determine the effects of consuming iron-biofortified beans (Fe-Beans) on the iron status in children, compared to control beans (Control-Beans). A cluster-randomized trial of biofortified beans (Phaseolus vulgaris L), bred to enhance iron content, was conducted over 6 months. The participants were school-aged children (n = 574; 5–12 years), attending 20 rural public boarding schools in the Mexican state of Oaxaca. Double-blind randomization was conducted at the school level; 20 schools were randomized to receive either Fe-Beans (n = 10 schools, n = 304 students) or Control-Beans (n = 10 schools, n = 366 students). School administrators, children, and research and laboratory staff were blinded to the intervention group. Iron status (hemoglobin (Hb), serum ferritin (SF), soluble transferrin receptor (sTfR), total body iron (TBI), inflammatory biomarkers C-reactive protein (CRP) and -1-acid glycoprotein (AGP)), and anthropometric indices for individuals were evaluated at the enrollment and at the end of the trial. The hemoglobin concentrations were adjusted for altitude, and anemia was defined in accordance with age-specific World Health Organization (WHO) criteria (i.e., Hb <115 g/L for <12 years and Hb <120 g/L for 12 years). Serum ferritin concentrations were adjusted for inflammation using BRINDA methods, and iron deficiency was defined as serum ferritin at less than 15.0 µg/L. Total body iron was calculated using Cook’s equation. Mixed models were used to examine the effects of Fe-Beans on hematological outcomes, compared to Control-Beans, adjusting for the baseline indicator, with school as a random effect. An analysis was conducted in 10 schools (n = 269 students) in the Fe-Beans group and in 10 schools (n = 305 students) in the Control-Beans group that completed the follow-up. At baseline, 17.8% of the children were anemic and 11.3% were iron deficient (15.9%, BRINDA-adjusted). A total of 6.3% of children had elevated CRP (>5.0 mg/L), and 11.6% had elevated AGP (>1.0 g/L) concentrations at baseline. During the 104 days when feeding was monitored, the total mean individual iron intake from the study beans (Fe-bean group) was 504 mg (IQR: 352, 616) over 68 mean feeding days, and 295 mg (IQR: 197, 341) over 67 mean feeding days in the control group (p < 0.01). During the cluster-randomized efficacy trial, indicators of iron status, including hemoglobin, serum ferritin, soluble transferrin receptor, and total body iron concentrations improved from the baseline to endline (6 months) in both the intervention and control groups. However, Fe-Beans did not significantly improve the iron status indicators, compared to Control-Beans. Similarly, there were no significant effects of Fe-Beans on dichotomous outcomes, including anemia and iron deficiency, compared to Control-Beans. In this 6-month cluster-randomized efficacy trial of iron-biofortified beans in school children in Mexico, indicators of iron status improved in both the intervention and control groups. However, there were no significant effects of Fe-Beans on iron biomarkers, compared to Control-Beans. This trial was registered at clinicaltrials.gov as NCT03835377.

scholarly journals Differential effects of chronic iron deficiency anaemia on junctional and labyrinthine zones of placenta in Sprague dawely rat

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Omer Awad ◽  
Abdel Malek ◽  
Julius Ogeng’o
Keyword(s):  
Iron Deficiency ◽  
Gestational Age ◽  
Iron Deficiency Anaemia ◽  
Control Group ◽  
Albino Rats ◽  
Control Groups ◽  
Junctional Zone ◽  
Deficiency Anaemia ◽  
The Difference ◽  
And Control

Iron deficiency anaemia causes adverse pregnancy outcome. Studies reveal its generalized effects on histomorphometry of the placenta, without details on specific zones nor effect of gestational age. These data are important for planning  intervention. This study was, therefore, designed to describe the histomorphometric changes associated with iron deficiency anaemia on placenta of albino rat. Fourty nine (49) Sprague – Dawely albino rats were randomly separated into experimental and control groups. The  experimental group was rendered anaemic by removing 1.5 ml of blood per bleed on five alternate days. Placentas were collected on gestational days 17, 19 and 21. Five cubic milimetre segments were fixed in 10 % buffered formaldehyde solution; dehydrated in ethanol and embedded in paraffin wax. Five micron thick sections were cut, deparaffinized and stained with Hematoxylin and Eosin. Micrographs were taken using Leica ICC 50 digital photomicrographic camera attached to a computer at magnification x40 and the thickness of the labyrinth and junctional zones measured. Student t- test was used to compare values for the   experimental and control groups. The labyrinth in the chronic anaemia group was thinner than in the control group at gestational days 17, 19 and 21. The junctional zone, on the other hand, was consistently thicker in anaemic than in the control animals. The difference in thickness of junctional zone varied with  gestational age. At gestational day 17, the zone was significantly thicker in the anaemic group (628.9 μ) than in the control (381 μ). On day 19 and 21, however, the difference was not statistically  significant. In conclusion, the effects of chronic iron deficiency anaemia on the labyrinth differ from those on the junctional zone of the placenta. This differential effect appears to depend on the function and gestational age. The decrease in thickness of the  labyrinth may be designed to maintain placental diffusion capacity while increased thickness of the junctional zone constitutes a compensatory physical and nutritional adaptation to hypoxia.Key words: placenta, labyrinthine, junctional zones, thickness, anaemia.

scholarly journals Evaluation of Iron Status in Children with Autism Spectral Disorder: A Case-control Study

2021 ◽  
Author(s):  
Pritam Prakash ◽  
Rekha Kumari ◽  
Niska Sinha ◽  
Santosh Kumar ◽  
Poonam Sinha
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Case Control Study ◽  
Iron Status ◽  
Children With Autism ◽  
Case Control ◽  
Control Groups ◽  
Ferritin Iron ◽  
And Control ◽  
Control Study

Introduction: Iron is an important factor in neural development. Iron Deficiency (ID) and Iron Deficiency Anaemia (IDA) anaemia is highly prevalent in patients of autism. There are a very small number of studies to show association between iron profile and autism. Aim: To investigate factors affecting iron status such as hemoglobin (%), serum iron, ferritin, and Total Iron Binding Capacity (TIBC) level in children with Autism Spectral Disorder (ASD) and healthy control. Materials and Methods: It was a case-control study done from April 2018 to April 2019. Total 100 participants were recruited of which 50 autistic patients were taken as cases, and 50 healthy subjects were taken as control. Childhood Autism Rating Scale (CARS) was used to evaluate the severity of autistic symptoms. Cut-off value of serum ferritin was <10 ng/mL for preschoolers (<6 years) and <12 ng/mL for school-aged (>6 years) children to evaluate ID. Anaemia was defined as haemoglobin <11.0 g/dL for preschoolers and <12.0 g/dL for school-aged categorical variables and were compared by using chi-square test. Normally distributed parametric variables were compared between groups by using independent samples t-test. Serum ferritin, iron, TIBC values were compared between severe, mild-moderate and control groups with ANOVA. The p-value <0.05 was accepted to be statistically significant. Results: Mean serum levels of ferritin iron TIBC were significantly reduced in ASD patients (p<0.001). The level of haemoglobin was also lower in ASD patients but it was not significant. Risk of ID and IDA was higher than normal subjects (RR for ID 1.74). Level of serum ferritin, iron and TIBC was lowest in severe autism as compared to mild-moderate autism and control groups. Conclusion: These findings suggest iron and ferritin levels should be measured in autistic patients as a baseline investigation and it may be used as a screening test for ASD.

Comparison of Erythropoietin, GDF-15, IL-6 and Hepcidin Levels In a Large Cohort of Elderly Individuals with Anemia of Known and Unknown Etiology

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 2037-2037
Author(s):  
Katharina von Loehneysen ◽  
Xiuling Xu ◽  
Pauline Lee ◽  
Jill Waalen ◽  
Jeff S. Friedman
Keyword(s):  
Chronic Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Correlation Analysis ◽  
Laboratory Data ◽  
Unknown Etiology ◽  
Control Group ◽  
Control Groups ◽  
Elderly Individuals ◽  
And Control

Abstract Abstract 2037 Several epidemiologic studies have documented an increasing frequency of anemia in individuals 65 years and older. Elderly individuals with anemia have been categorized into those with chronic disease, those with iron, B12, or folate deficiency, and those with ’unexplained anemia’ –with roughly 1/3 of cases assigned to each category based upon laboratory data and clinical history. Unexplained anemia (AUE—or anemia of unknown etiology) remains a diagnosis of exclusion. The heterogeneity or homogeneity of this population will become clear with identification of cause(s) of anemia, and development of specific screening tests that are characteristic of some or all individuals assigned to this group. There is considerable interest and debate as to whether AUE has an inflammatory component, represents early presentation of marrow dysfunction such as myelodysplasia, is a manifestation of cellular aging such as telomere shortening or mitochondrial dysfunction, or represents a novel pathologic process. Here we compare a large cohort (167 patients) of AUE cases with a matched, non-anemic control group (170 patients), and a group of age-matched individuals with anemia of defined cause (144 patients divided as follows: 77 iron deficiency, 34 kidney disease, 24 elevated white cell count, 10 alcohol abuse). Patient plasma was assayed for IL-6, hepcidin, GDF-15, erythropoietin (Epo) and testosterone (males only). IL-6 levels did not differ between the AUE and the control groups. Similarly, hepcidin levels (see figure below) were not elevated in the AUE versus control group comparison. Interestingly, GDF-15 levels were significantly elevated when comparing AUE to controls. GDF-15 levels in the defined anemia groups varied—with no change in the iron deficiency group, but marked elevation in patients with kidney disease. Epo levels strongly discriminated between the iron deficiency and control groups, but only weakly discriminated the AUE and control groups. Correlation analysis between hemoglobin levels and Epo expression confirm this blunted response in the AUE group. Correlation analysis also revealed a consistent and significant positive relationship between Epo and GDF-15 expression across multiple groups, but no consistent relationship between GDF-15 and hepcidin expression. Testosterone level in males was not significantly different in any comparison. However, there were differences observed between sexes in this analysis, particularly in expression of GDF-15. In summary, our results indicate that that neither inflammation nor iron-restriction (as seen in anemia of chronic disease due to elevated hepcidin) play significant roles in development of anemia in the AUE cohort. GDF-15 levels, on the other hand, may be a useful discriminator. We are currently using a clustering approach to determine whether the AUE group can be further subdivided based upon patterns of expression of these analytes along with additional clinical and laboratory data available on this cohort. Disclosures: No relevant conflicts of interest to declare.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

Sign in / Sign up

Export Citation Format

Share Document