scholarly journals H. pyloriMay Not Be Associated with Iron Deficiency Anemia in Patients with Normal Gastrointestinal Tract Endoscopy Results

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Tayyibe Saler ◽  
Şakir Özgür Keşkek ◽  
Sibel Kırk ◽  
Süleyman Ahbab ◽  
Gülay Ortoğlu
Keyword(s):  
Gastrointestinal Tract ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Male Patients ◽  
H Pylori ◽  
And Control

Background. The aim of this study was to investigate the association between iron deficiency anemia andH. pyloriin patients with normal gastrointestinal tract endoscopy results.Materials and Methods. A total of 117 male patients with normal gastrointestinal tract endoscopy results were included in this retrospective study. The study and control groups included 69 and 48 patients with and without iron deficiency anemia, respectively. The prevalence ofH. pylori, the number of RBCs, and the levels of HGB, HTC, MCV, iron, and ferritin were calculated and compared.Results. There was no statistically significant difference found between the groups according to the prevalence ofH. pylori(65.2% versus 64.6%,P=0.896). Additionally, the levels of RBCs, HGB, HTC, MCV, iron, and ferritin in the patients in the study group were lower than those in the control group (P<0.05). Finally, there was no association between iron deficiency anemia andH. pylori(OR 1.02, Cl 95% 0.47–2.22, andP=0.943).Conclusion.H. pyloriis not associated with iron deficiency anemia in male patients with normal gastrointestinal tract endoscopy results.

SOLUBLE TRANSFERRIN RECEPTOR IS A PROMISING MARKER of IRON DEFICIENCY ANEMIA IN PREVALENT HEMODIALYSIS PATIENTS

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Khaled Abou seif ◽  
Hussien Sayed Hussien ◽  
Shaimaa Abdelmegied ◽  
Marwa Abdulhady
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Transferrin Receptor ◽  
Iron Status ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
P Value ◽  
Soluble Transferrin Receptor ◽  
Significant Difference ◽  
And Control

Abstract: Background Diagnosis of iron deficiency is traditionally based on ferritin and other iron parameters becomes difficult in end stage renal disease patients due to the inflammatory condition which affects these markers and masks the iron deficiency. Serum soluble transferrin receptor (sTfR) is able to be a reliable indicator for assessing iron status, as it is not affected by inflammatory procedures. Aim To evaluate the usefulness of serum soluble transferrin receptors in iron deficiency anemia detection in comparison to the classic markers of iron status in prevalent hemodialysis patients. Methods This case-control study assessed sTfR in 80 prevalent ESRD patients on regular hemodialysis in 2 groups. Group A (N = 40): CRP &gt;10 and group B (N = 40):CRP &lt;10 and apparently healthy 8 control subjects. Results The cut of value of STFRs in hemodialysis patients was 12.5 mg\l. The prevalence of STFRs in patients with CRP&lt;10 was 85%, while in patients with CRP&gt;10 was 92.5% (P-value 0.288). STFRs have high sensitivity 88.75, specificity 100, PPV100% and NPV 47.1%. The hemodialysis patients who have elevated STFRs have risk 1.22 times to have iron deficiency anemia if CRP &lt;10 (odds ratio: 1.22) and 3.14 times if CRP&gt;10 (odds ratio: 3.14). There was significant difference on comparing patients with CRP&lt;10, CRP&gt;10 and control as regard Hb and STFR with P-value 0.0001 and 0.0001 respectively. Post Hoc analysis showed significant difference in both between the patients with CRP&lt;10 and control also in patients with CRP&gt;10 and control (p value &lt;0.0001). while on comparing patients with CRP&lt;10 with patients with CRP&gt;10 there was significant difference in STFRs p value 0.0001 despite no significant difference in hemoglobin (p value 0.642) and classic marker of iron deficiency (s.iron, TIBC, TSAT) with p value 0.701,0.192,0.382 respectively. Serum STFRs was negatively correlated with s.iron and Kt\v (r -0.372, P-value 0.018) and (r-0.416, p value 0.008) respectively in patients with CRP &lt;10. Conclusion Serum soluble transferrin receptor is highly sensitive and specific marker for iron deficiency in hemodialysis patients especially in patients with high CRP level.

scholarly journals SUBCUTANEOUS ADIPOSE TISSUE IN FEMALE PATIENTS WITH IRON DEFICIENCY ANEMIA AND OBESE WOMEN DOES NOT DIFFER IN THE EXPRESSION OF IKBΑ*

2018 ◽  
Vol 22 (3-4) ◽  
pp. 14-17
Author(s):  
V.M. Nedoborenko ◽  
O.А. Shlykova ◽  
O.V. Izmailova ◽  
K.E. Ishcheikin ◽  
I.P. Kaidashev
Keyword(s):  
Adipose Tissue ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Subcutaneous Adipose Tissue ◽  
Deficiency Anemia ◽  
Control Group ◽  
Obese Women ◽  
Female Patients ◽  
Significant Difference ◽  
Subcutaneous Adipose

Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression increases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Methods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by subcutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclusion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.

scholarly journals The Effect of Anemia Free Club Interventions to Improve Knowledge and Attitude of Nutritional Iron Deficiency Anemia Prevention among Adolescent Schoolgirls in Bandar Lampung City, Indonesia

2020 ◽  
Vol 8 (E) ◽  
pp. 36-40
Author(s):  
Reni Zuraida ◽  
Nur Indrawati Lipoeto ◽  
Masrul Masrul ◽  
Judhiastuty Februhartanty
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Intervention Program ◽  
Intervention Group ◽  
Public Health Problem ◽  
Developed Countries ◽  
Deficiency Anemia ◽  
Control Group ◽  
Control Groups ◽  
Knowledge And Attitude

BACKGROUND: Anemia in adolescent is a global public health problem affecting both developing and developed countries. Adolescents are at high risk of anemia. School-based interventions are important to decrease the anemia. AIM: This study was performed to determine the effect of anemia free club interventions to improve knowledge and attitude of nutritional iron deficiency anemia prevention among adolescent schoolgirls in Bandar Lampung City, Indonesia. METHODS: The authors conducted a quasi-experimental. The study sample consists of 55 intervention groups and 47 control groups of senior high schoolgirls in Bandar Lampung City. The intervention group attended nutrition education–based, namely, anemia free club sessions for 12 weeks, while the control group did not. The sampling technique is proportional random sampling. Before and after the intervention program, knowledge and attitude questionnaire were filled out for both the groups. A paired sample t-test was used for data analysis. p < 0.05 was considered as statistically significant effect. Finally, data were collected and analyzed by the SPSS program. RESULTS: This study known before the intervention, there were no significant differences regarding the knowledge and attitude in two groups (p > 0.05). After the intervention, there were significant differences in the levels of knowledge and attitude between intervention and control groups (p < 0.05). CONCLUSION: This analysis confirmed an effect of anemia free club interventions to improve knowledge and attitude of nutritional iron deficiency anemia prevention among adolescent schoolgirls.

scholarly journals The Relationship Between Infertility and Infection with Clarithromycin Resistant Strain of Helicobacter Pylori in Iraq

2020 ◽  
pp. 1874-1879
Author(s):  
Shiamaa G. Abid ◽  
Rana S. Aboud
Keyword(s):  
Helicobacter Pylori ◽  
Seminal Fluid ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Polymerase Chain ◽  
H Pylori ◽  
And Control ◽  
The Relationship ◽  
Infertile Patients

The relationship between infertility and Helicobacter pylori infection was investigated; samples from thirty-five infertile patients (aged 20-49 years) were collected from Kamal Al-Samaraei hospital , Baghdad, Iraq during the period from the first of February until April 2018. These patients were compared with 10 apparently fertile individuals who served as a control. The study was carried out to detect the DNA of H.pylori in both serum and seminal fluid of male infertile patients and for the control group by Real-Time Polymerase Chain Reaction (RT-PCR) technique. The results revealed that there was a significant difference (P<0.01) in the detection of DNA of H.pylori between patients and control groups. thereby the percentage level of H.pylori DNA in serum was 80% and in the seminal fluid was 0 %. As a result, we strongly suggest that the infection with H. pylori plays an important role in male infertility.

MO789SERUM SOLUBLE TRANSFERRIN RECEPTOR IS A PROMISING  MARKER OF IRON DEFICIENCY ANEMIA IN PREVALENT HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Khaled Abouseif ◽  
Hussein Abdallah ◽  
Marwa Abdulhady ◽  
Shaimaa Zaki abdelmegied
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Transferrin Receptor ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
P Value ◽  
Soluble Transferrin Receptor ◽  
Significant Difference ◽  
And Control ◽  
Esrd Patients

Abstract Background and Aims End stage renal disease (ESRD) is chronic inflammatory condition which affects iron parameters. Serum soluble transferrin receptor (sTfR) is a reliable indicator for assessing iron status in inflammatory conditions. This study evaluates the usefulness of serum sTfR in iron deficiency anemia detection in prevalent hemodialysis patients. Method This case-control study included 40 ESRD patients on conventional hemodialysis with CRP&gt;10, 40 ESRD patients with CRP&lt;10 and 8 apparently healthy controls. Serum sTfR was measured for all patients and controls. Results STFRs predicts iron deficiency anemia in prevalent hemodialysis patients at cut off value 12.5 mg/l with area under curve 0.949, sensitivity 88.75, specificity 100, PPV 100% and NPV 47.1%. The prevalence of STFRs in patients with CRP&lt;10 was 85%, while in patients with CRP&gt;10 was 92.5% (P-value 0.288). Patients who have elevated STFRs have risk 1.22 times to have iron deficiency anemia if CRP &lt;10 (odds ratio: 1.22) and 3.14 times if CRP&gt;10 (odds ratio: 3.14). There was significant difference on comparing patients with CRP&lt;10, CRP&gt;10 and control as regard haemoglobin and STFR with P-value 0.0001 and 0.0001 respectively. Post Hoc analysis showed significant difference between the patients with CRP&lt;10 and control also in patients with CRP&gt;10 and control as regard haemoglobin and STFR (p value &lt;0.0001). on comparing patients with CRP&lt;10 with patients with CRP&gt;10 there was significant difference in STFRs p value 0.0001 despite no significant difference in haemoglobin (p value 0.642) and classic iron markers (s.iron, TIBC, TSAT) with p value 0.701, 0.192, 0.382 respectively. Serum STFRs was negatively correlated with s.iron and Kt\v in patients with CRP &lt;10 (r -0.372, P-value 0.018) and (r-0.416, p value 0.008) respectively. Conclusion Serum soluble transferrin receptor is a highly sensitive and specific marker of iron deficiency anemia in hemodialysis patients especially with high CRP level.

scholarly journals Cytomorphometric Analysis of Buccal Exfoliated Cells in Patients With Iron Deficiency Anemia

2020 ◽  
Author(s):  
Mahdieh Rajabi-Moghaddam ◽  
Hamid Abbaszadeh ◽  
Maryam Mosaffa ◽  
Hemmat Gholinia ◽  
Shima Nafarzadeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Exfoliative Cytology ◽  
Nuclear Pleomorphism ◽  
Mean Values ◽  
Cytoplasmic Area ◽  
Exfoliated Cells ◽  
Significant Difference

Iron deficiency anemia can cause histopathologic alterations in the oral mucosa. Exfoliative cytology is a cheaper and less aggressive method for early diagnosis. The aim of this study was to compare the cytological and cytomorphometric characteristics of buccal exfoliated cells of iron deficiency anemic patients with those of healthy controls. This case-control study compared a group of 40 patients with iron deficiency anemia (IDA) with an age- and gender-matched control group (C) of 40 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytological analyses. Cellular clumping, cytoplasmic diameter (CD), nuclear diameter (ND), cytoplasmic area (CA), nuclear area (NA), nucleus to cytoplasmic area ratio (NA/CA), cellular and nuclear pleomorphism, micronuclei (Mn), binucleation, bacterial colonies, and keratin flakes were evaluated using a light microscope and digital image analysis. Mean values for IDA and C groups were: bacterial colonies (1.88 and 0.65; P=0.002); CA (2209.88 and 1687.79 μm²; P=0.006); Mn (1.60 and 0.60; P=0.02). Significant increases in bacterial colonies, CA and Mn were seen for the IDA group. The number of cellular clumps, CD, ND, NA, NA/CA, cellular and nuclear pleomorphism, binucleation, and the number of keratin flakes didn’t show significant differences between studied groups (P>0.05). There wasn’t any significant difference with respect to overall atypia. This study revealed that IDA was able to induce significant changes in CA and Mn of the oral epithelial cells. Exfoliative cytology and cytomorphometry can be used as a tool to assess the mucosal changes in IDA patients.

scholarly journals IRON DEFICIENCY ANEMIA

2018 ◽  
Vol 21 (04) ◽  
pp. 734-738
Author(s):  
Syed Qamar `Zaman ◽  
Arshad Mahmood ◽  
Shabbir Ahmed ◽  
Shahid Mahmud
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Odds Ratio ◽  
Deficiency Anemia ◽  
Breath Holding ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Significant Difference ◽  
Qualitative Variables

Objective: To determine the association of breath holding spells with irondeficiency anemia in children. Study Design: Case control study. Place and Duration of Study:Military Hospital Rawalpindi from Jun 2012 to Dec 2012. Study Population: Sixty children ofeither gender meeting inclusion criteria aged 6 months to 5 years with 30 of breath holding spells incase group and 30 in control group as healthy children were included in the study after informedconsent from parents. Method: Complete blood picture and serum ferritin levels were performedof all children in both case and control groups. Tests were carried out at AFIP Rawalpindi. All datawas entered and analyzed using SPSS version 10. Frequencies and percentages were calculatedfor categorical (qualitative) variables like sex and children having iron deficiency anemia in casesand controls. Mean and Standard Deviation (SD) was calculated for numerical (quantitative)variable like Age. Odds ratio was calculated from the data of cases and controls. Regarding irondeficiency anemia p value <0.05 was considered as significant. Results: In this study, werecorded 43.33% (n=13) cases were between 0.6-3 years and 56.67% (n=17) were between 4-5years while 53.33% (n=16) controls were between 0.6-3 years and 46.67% (n=14) were between4-5 years. Mean±SD was calculated as 3.3+1.46 years in cases and 2.93+1.48 years in controlgroup. Male children were 60% (n=18) in patient group and 46.67% (n=14) in controls group.Female children were 40% (n=12) in patient and 53.33% (n=16) in control group respectively.Association of breath holding spells with iron deficiency anemia in children revealed as 56.67%(n=17) in cases and 3.33% (n=1) in control group while remaining 43.33% (n=13) in cases and96.67% (n=29) in control group had no findings of this association. P value was calculated as<0.0001 and Odds Ratio was 37.92 which shows a significant difference between the two groups.Conclusions: The association of breath holding spells with iron deficiency anemia in children issignificantly higher than healthy controls. So, it is recommended that every child who present withbreath holding spells should be evaluated for iron deficiency anemia

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Impact of intrawound vancomycin powder on prevention of surgical site infection after posterior spinal surgery

2021 ◽  
pp. 1-9
Author(s):  
Hiroki Ushirozako ◽  
Tomohiko Hasegawa ◽  
Yu Yamato ◽  
Go Yoshida ◽  
Tatsuya Yasuda ◽  
...  
Keyword(s):  
Propensity Score ◽  
Spinal Surgery ◽  
Control Group ◽  
Control Groups ◽  
Propensity Score Model ◽  
Significant Difference ◽  
Surgical Data ◽  
Vancomycin Powder ◽  
Vancomycin Group ◽  
And Control

OBJECTIVESurgical site infection (SSI) after posterior spinal surgery is one of the severe complications that may occur despite administration of prophylactic antibiotics and the use of intraoperative aseptic precautions. The use of intrawound vancomycin powder for SSI prevention is still controversial, with a lack of high-quality and large-scale studies. The purpose of this retrospective study using a propensity score–matched analysis was to clarify whether intrawound vancomycin powder prevents SSI occurrence after spinal surgery.METHODSThe authors analyzed 1261 adult patients who underwent posterior spinal surgery between 2010 and 2018 (mean age 62.3 years; 506 men, 755 women; follow-up period at least 1 year). Baseline and surgical data were assessed. After a preliminary analysis, a propensity score model was established with adjustments for age, sex, type of disease, and previously reported risk factors for SSI. The SSI rates were compared between patients with intrawound vancomycin powder treatment (vancomycin group) and those without (control group).RESULTSIn a preliminary analysis of 1261 unmatched patients (623 patients in the vancomycin group and 638 patients in the control group), there were significant differences between the groups in age (p = 0.041), body mass index (p = 0.013), American Society of Anesthesiologists classification (p < 0.001), malnutrition (p = 0.001), revision status (p < 0.001), use of steroids (p = 0.019), use of anticoagulation (p = 0.033), length of surgery (p = 0.003), estimated blood loss (p < 0.001), and use of instrumentation (p < 0.001). There was no significant difference in SSI rates between the vancomycin and control groups (21 SSIs [3.4%] vs 33 SSIs [5.2%]; OR 0.640, 95% CI 0.368–1.111; p = 0.114). Using a one-to-one propensity score–matched analysis, 444 pairs of patients from the vancomycin and control groups were selected. There was no significant difference in the baseline and surgical data, except for height (p = 0.046), between both groups. The C-statistic for the propensity score model was 0.702. In the score-matched analysis, 12 (2.7%) and 24 (5.4%) patients in the vancomycin and control groups, respectively, developed SSIs (OR 0.486, 95% CI 0.243–0.972; p = 0.041). There were no systemic complications related to the use of vancomycin.CONCLUSIONSThe current study showed that intrawound vancomycin powder was useful in reducing the risk of SSI after posterior spinal surgery by half, without adverse events. Intrawound vancomycin powder use is a safe and effective procedure for SSI prevention.

Study to Evaluate Efficacy of Vajravatakmaņdura in Iron Deficiency Anemia in Adolescent Girls: A Randomized Controlled Trial

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Rashmi Pareek Ayatullah Hosne Asif ◽  
Nisha Kumari Ojha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Adolescent Girls ◽  
Controlled Trial ◽  
Control Programme ◽  
Deficiency Anemia ◽  
Group A ◽  
The Government ◽  
Trial Drug ◽  
And Control

Background: Anemia in adolescent girls possess greatest burden on their health as it leads to poor cognitive development, poor reproductive health and if not treated may lead to intrauterine growth retardation in their developing fetus. The prevalence of anemia among adolescent is 27% in developing country and 6% in developed country. The Government of India has launched National Anemia Control Programme, to prevent and control anaemia in children and adolescents. But the problem is still persisting because of many issues like - poor palatability, intolerance to the drug used, poor absorption of the drugs used, constipation, discoloration of stool, unpleasant odor and taste etc. result in poor compliance and therefore non adherence to the therapy which finally results in poor improvement. By looking at the magnitude of the problem, an Ayurveda drug Vajravatakmandura has been selected for the study and the present study was undertaken to evaluate the efficacy of the trial drug in iron deficiency anemia in adolescent girls. Material and methods: 100 subjects satisfying inclusion and exclusion criteria were selected and were randomly divided in two groups. In group A, the trial drug Vajravatakmaņdura was administered and in group B, IFA tablets were given for two month of duration with follow up at every fortnight. Result: Both the trial and control groups showed extremely significant result over subjective parameters. Trial drug Vajravatakmaņdura in group A was found more effective over the subjective parameters - weakness, palpitation, pallor and loss of appetite with % gain of 39.77%, 39.39%, 39.17%, 38.09% respectively. Statistical analysis between before and after treatment findings of objective parameters, extremely significant (P less than 0.0001) improvement was found in both groups in all parameters, except for RBC count in group A, which was significant. No adverse effects were reported during entire period of study by any of the patients in trial group treated with trial drug. Conclusion: The trial drug “Vajravatakmandura” is effective, safe and palatable for the management of iron deficiency anemia in adolescent girls.

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