Angiotensin ii increases VEGF expression and peroxynitrite-dependent MMP-2 activation in the rat aorta: Preventive effect of red wine polyphenols

2006 ◽  
Vol 45 (3) ◽  
pp. e74-e75
Author(s):  
A. Walter ◽  
M. Sarr ◽  
N. Etienne ◽  
A. Beretz ◽  
V.B. Schini-Kerth
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Rat Aorta ◽  
Preventive Effect ◽  
Vegf Expression ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Angiotensin II Induces the Vascular Expression of VEGF and MMP-2 in vivo: Preventive Effect of Red Wine Polyphenols

2008 ◽  
Vol 45 (5) ◽  
pp. 386-394 ◽  
Author(s):  
Allison Walter ◽  
Nelly Etienne-Selloum ◽  
Mamadou Sarr ◽  
Modou Oumy Kane ◽  
Alain Beretz ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Preventive Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
Vascular Expression

Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols

2009 ◽  
Vol 459 (5) ◽  
pp. 671-679 ◽  
Author(s):  
Modou O. Kane ◽  
Nelly Etienne-Selloum ◽  
Soccoro V. F. Madeira ◽  
Mamadou Sarr ◽  
Allison Walter ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Red Wine ◽  
Rat Aorta ◽  
Ang Ii ◽  
Preventive Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Red Wine Polyphenols Prevent Acceleration of Neovascularization by Angiotensin II in the Ischemic Rat Hindlimb

2009 ◽  
Vol 329 (2) ◽  
pp. 699-707 ◽  
Author(s):  
Allison Walter ◽  
Nelly Etienne-Selloum ◽  
David Brasse ◽  
René Schleiffer ◽  
Virgile Bekaert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

scholarly journals Intake of red wine polyphenols prevents the stimulatory effect of angiotensin II on ischemia‐induced neovascularization in the rat hindlimb

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Walter Allison ◽  
Etienne Nelly ◽  
Brasse David ◽  
Schlieffer René ◽  
Beretz Alain ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols

2009 ◽  
Vol 51 (2-3) ◽  
pp. 140-146 ◽  
Author(s):  
Modou Oumy Kane ◽  
Eric Anselm ◽  
Yanna Dantas Rattmann ◽  
Cyril Auger ◽  
Valérie B. Schini-Kerth
Keyword(s):  
Estrogen Receptors ◽  
Red Wine ◽  
Rat Aorta ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
Endothelium Dependent Relaxation

Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells

2006 ◽  
Vol 44 (6) ◽  
pp. 898-902 ◽  
Author(s):  
M.-J. Kim ◽  
Y.-J. Kim ◽  
H.-J. Park ◽  
J.-H. Chung ◽  
K.-H. Leem ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Red Wine ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Apoptotic Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

scholarly journals eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study

2013 ◽  
Vol 60 (1) ◽  
pp. 27-33 ◽  
Author(s):  
E. Kurin ◽  
N. Fakhrudin ◽  
M. Nagy
Keyword(s):  
Reporter Gene ◽  
Red Wine ◽  
Interaction Analysis ◽  
Mass Action ◽  
Luciferase Reporter ◽  
Interaction Study ◽  
Luciferase Reporter Gene ◽  
Gene Assay ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Beneficial effects of red wine polyphenols on cardiovascular health are well known. The aim of our research was an interaction study of four red wine polyphenols – resveratrol (R), quercetin (Q), kaempferol (KF) and isorhamnetin (IR) of their ability to activate endothelial NO synthase (eNOS) promoter when used alone and in equimolar mixtures. To determine their activity, we performed a luciferase reporter gene assay on EA.hy926 cells stably transfected with a luciferase reporter gene construct containing eNOS promoter. The Bradford assay was also performed to account the cytotoxicity and/or the cell number differences. The median effect equation, as an interaction analysis evaluating synergy or antagonism of the combinations was done according to mass-action law principle. Isobolographic method was performed on selected double mixtures and dose reduction index was calculated for all mixtures. All single polyphenols activated eNOS promoter. The EC50 values were in micromolar concentrations ranging from 3.44 μM (R2 = 0.96) for kaempferol to 9.89 μM for isorhamnetin (R2 = 0.94). All mixtures activated eNOS promoter, but their interactions varied from synergy (Q+R, Q+IR+KF, Q+R+KF and Q+R+IR+KF), through additive (R+IR+KF) to antagonistic interaction (R+IR, R+KF, Q+IR, Q+KF, IR+KF and R+Q+IR). In this study, we show for the first time that red wine polyphenols activated eNOS promoter when used alone and in mixtures with different type of interactions.

scholarly journals Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension

2012 ◽  
Vol 25 (6) ◽  
pp. 718-723 ◽  
Author(s):  
I. P. G. Botden ◽  
R. Draijer ◽  
B. E. Westerhof ◽  
J. H. W. Rutten ◽  
J. G. Langendonk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Red Wine ◽  
Normal Blood ◽  
Central Blood Pressure ◽  
Normal Blood Pressure ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols
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