Angiotensin II-induced endothelial dysfunction in the rat aorta involves the cyclooxygenases-dependent formation of an endothelium-derived contracting factor(s): preventive effect of red wine polyphenols

2006 ◽  
Vol 45 (3) ◽  
pp. e13-e14 ◽  
Author(s):  
N. Etienne ◽  
M. Kane ◽  
M. Sarr ◽  
M. Chataigneau ◽  
A. Walter ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Red Wine ◽  
Rat Aorta ◽  
Preventive Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols

2009 ◽  
Vol 459 (5) ◽  
pp. 671-679 ◽  
Author(s):  
Modou O. Kane ◽  
Nelly Etienne-Selloum ◽  
Soccoro V. F. Madeira ◽  
Mamadou Sarr ◽  
Allison Walter ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Red Wine ◽  
Rat Aorta ◽  
Ang Ii ◽  
Preventive Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Angiotensin II Induces the Vascular Expression of VEGF and MMP-2 in vivo: Preventive Effect of Red Wine Polyphenols

2008 ◽  
Vol 45 (5) ◽  
pp. 386-394 ◽  
Author(s):  
Allison Walter ◽  
Nelly Etienne-Selloum ◽  
Mamadou Sarr ◽  
Modou Oumy Kane ◽  
Alain Beretz ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Preventive Effect ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
Vascular Expression

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase

2010 ◽  
Vol 120 (8) ◽  
pp. 321-333 ◽  
Author(s):  
Rocío López-Sepúlveda ◽  
Manuel Gómez-Guzmán ◽  
Maria José Zarzuelo ◽  
Miguel Romero ◽  
Manuel Sánchez ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Nadph Oxidase ◽  
Endothelial Function ◽  
Oxidase Activity ◽  
Red Wine ◽  
Vascular Wall ◽  
Nadph Oxidase Activity ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
O2 Production

RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O2•− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O2•− production induced by ET-1 and to analyse the compounds responsible for these protective effects. We incubated rat isolated aortic rings in the presence or absence of ET-1 (10 nM) and RWPs (10−4 to 10−2 g/l) or catechin (0.2 μM), epicatechin (10 μM) and resveratrol (0.1 μM). ET-1 reduced the relaxant responses to acetylcholine, increased intracellular O2•− production, NADPH oxidase activity and protein expression of NADPH oxidase subunit p47phox. All these changes were prevented by RWPs. The preventive effects of RWPs were unaffected by co-incubation with either ICI-182780, an ER (oestrogen receptor) antagonist, or GW9662, a PPARγ (peroxisome-proliferator-activated receptor γ) antagonist. RWPs inhibited the phosphorylation of the mitogen-activated protein kinase, ERK1/2 (extracellular signal-regulated kinase 1/2), a key regulator of p47phox expression in response to ET-1. When the isolated polyphenols were tested, at the concentrations found in 10−2 g/l RWPs, only epicatechin prevented endothelial dysfunction and all biochemical changes induced by ET-1 in the vascular wall. Taken together, these results indicate that RWPs prevent ET-1-induced vascular O2•− production by reducing overexpression of p47phox and the subsequent increased NADPH oxidase activity, leading to improvement in endothelial function. The effects of RWPs appear to be independent of ER and PPARγ activation and are related to ERK1/2 inhibition.

Red Wine Polyphenols Prevent Acceleration of Neovascularization by Angiotensin II in the Ischemic Rat Hindlimb

2009 ◽  
Vol 329 (2) ◽  
pp. 699-707 ◽  
Author(s):  
Allison Walter ◽  
Nelly Etienne-Selloum ◽  
David Brasse ◽  
René Schleiffer ◽  
Virgile Bekaert ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

scholarly journals Intake of red wine polyphenols prevents the stimulatory effect of angiotensin II on ischemia‐induced neovascularization in the rat hindlimb

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Walter Allison ◽  
Etienne Nelly ◽  
Brasse David ◽  
Schlieffer René ◽  
Beretz Alain ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Red Wine ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols

Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols

2009 ◽  
Vol 51 (2-3) ◽  
pp. 140-146 ◽  
Author(s):  
Modou Oumy Kane ◽  
Eric Anselm ◽  
Yanna Dantas Rattmann ◽  
Cyril Auger ◽  
Valérie B. Schini-Kerth
Keyword(s):  
Estrogen Receptors ◽  
Red Wine ◽  
Rat Aorta ◽  
Wine Polyphenols ◽  
Red Wine Polyphenols ◽  
Endothelium Dependent Relaxation
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