Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria

2007 ◽  
Vol 104 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Akishige Hokugo ◽  
Yasunori Sawada ◽  
Rie Hokugo ◽  
Hiromitsu Iwamura ◽  
Masakiyo Kobuchi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Regeneration

scholarly journals ID: 1059 Biomimetic release of growth factor from porous beads for enhanced bone regeneration

2017 ◽  
Vol 4 (S) ◽  
pp. 140
Author(s):  
Ho Yong Kim ◽  
June Ho Byun ◽  
Jin Ho Lee ◽  
Se Heang Oh
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Growth Factor ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Bioactive Molecules ◽  
Calcium Deposition ◽  
Boyden Chamber ◽  
New Bone Formation ◽  
Rt Pcr

Three dimensional scaffolds which allow sustained release of bioactive molecules have been considered as an essential component for enhanced bone regeneration. In recent years, combination system of various bioactive molecules has been extensively investigated to reconstruct more sophisticated bone regeneration. It is well-known that if the certain bioactive molecules with appropriate dose and stimulation periods are applied to bone defect, the physiological processes in bone regeneration may be accelerated. However, many studies were not concerned stimulation periods of bioactive molecules occurred in body during new bone formation because of absence of proper release system for the bioactive molecules. In this study, we selected three bioactive molecules (PDGF-BB, VEGF, BMP-2) which widely used for effective bone healing, and developed a porous bead with leaf-stacked structure which can allow controlled release of growth factors by concentration and composition of Pluronics. The morphology, each growth factor release profiles, migration (boyden chamber assay), angiogenic differentiation (tube formation, ICC, and RT-PCR), osteogenic differentiation (ALP activity, calcium deposition, alizarin/ALP staining, ICC, and RT-PCR) of human periosteum-derived cells and new bone formation of rat calvarial defect model by controlled release of growth factors were estimated

scholarly journals Cranial Bone Regeneration by Controlled Release of Platelet Growth Factors from Biodegradable Hydrogel

2005 ◽  
Vol 14 (2) ◽  
pp. 288-290 ◽  
Author(s):  
Akishige Hokugo ◽  
Yasunori Sawada ◽  
Kozo Mushimoto ◽  
Shosuke Morita ◽  
Yasuhiko Tabata
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Regeneration ◽  
Cranial Bone ◽  
Biodegradable Hydrogel

scholarly journals Delivery Systems and Role of Growth Factors for Alveolar Bone Regeneration in Dentistry

10.5772/55580 ◽  
2013 ◽  
Author(s):  
Stefano Sivolella ◽  
Marleen De ◽  
Giulia Brunello ◽  
Sara Ricci ◽  
Drazen Tadic ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Delivery Systems

Converted marine coral hydroxyapatite implants with growth factors: In vivo bone regeneration

2015 ◽  
Vol 49 ◽  
pp. 816-823 ◽  
Author(s):  
Samit K. Nandi ◽  
Biswanath Kundu ◽  
Jayanta Mukherjee ◽  
Arnab Mahato ◽  
Someswar Datta ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Regeneration
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