scholarly journals Cranial Bone Regeneration by Controlled Release of Platelet Growth Factors from Biodegradable Hydrogel

2005 ◽  
Vol 14 (2) ◽  
pp. 288-290 ◽  
Author(s):  
Akishige Hokugo ◽  
Yasunori Sawada ◽  
Kozo Mushimoto ◽  
Shosuke Morita ◽  
Yasuhiko Tabata
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Regeneration ◽  
Cranial Bone ◽  
Biodegradable Hydrogel

Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria

2007 ◽  
Vol 104 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Akishige Hokugo ◽  
Yasunori Sawada ◽  
Rie Hokugo ◽  
Hiromitsu Iwamura ◽  
Masakiyo Kobuchi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Regeneration

In situ controlled release of stromal cell-derived factor-1α and antimiR-138 for on-demand cranial bone regeneration

2018 ◽  
Vol 182 ◽  
pp. 215-224 ◽  
Author(s):  
Guangsheng Wu ◽  
Chao Feng ◽  
Jingjing Quan ◽  
Zhongshan Wang ◽  
Wei Wei ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Stromal Cell ◽  
Cranial Bone ◽  
On Demand ◽  
Stromal Cell Derived Factor

Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -

2005 ◽  
Vol 288-289 ◽  
pp. 253-256 ◽  
Author(s):  
Masaya Yamamoto ◽  
Yoshitake Takahashi ◽  
Yasuhiko Tabata
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Bone Defect ◽  
Animal Species ◽  
Bone Induction ◽  
Morphogenetic Protein ◽  
Biodegradable Hydrogel ◽  
Human Primate ◽  
Hydrogel System

The objective of this study is to examine feasibility of biodegradable gelatin hydrogels incorporating bone morphogenetic protein (BMP)-2 in inducing bone regeneration at a bone defect of non-human primates and rabbits considering their BMP-2 release profiles. As a result, controlled release by the hydrogel system enabled BMP-2 to induce successful bone regeneration in non-human primates even at the BMP-2 dose as low as that for rabbit case (0.034 mg of BMP-2/cm3 of hydrogel).

scholarly journals ID: 1059 Biomimetic release of growth factor from porous beads for enhanced bone regeneration

2017 ◽  
Vol 4 (S) ◽  
pp. 140
Author(s):  
Ho Yong Kim ◽  
June Ho Byun ◽  
Jin Ho Lee ◽  
Se Heang Oh
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Growth Factor ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Bioactive Molecules ◽  
Calcium Deposition ◽  
Boyden Chamber ◽  
New Bone Formation ◽  
Rt Pcr

Three dimensional scaffolds which allow sustained release of bioactive molecules have been considered as an essential component for enhanced bone regeneration. In recent years, combination system of various bioactive molecules has been extensively investigated to reconstruct more sophisticated bone regeneration. It is well-known that if the certain bioactive molecules with appropriate dose and stimulation periods are applied to bone defect, the physiological processes in bone regeneration may be accelerated. However, many studies were not concerned stimulation periods of bioactive molecules occurred in body during new bone formation because of absence of proper release system for the bioactive molecules. In this study, we selected three bioactive molecules (PDGF-BB, VEGF, BMP-2) which widely used for effective bone healing, and developed a porous bead with leaf-stacked structure which can allow controlled release of growth factors by concentration and composition of Pluronics. The morphology, each growth factor release profiles, migration (boyden chamber assay), angiogenic differentiation (tube formation, ICC, and RT-PCR), osteogenic differentiation (ALP activity, calcium deposition, alizarin/ALP staining, ICC, and RT-PCR) of human periosteum-derived cells and new bone formation of rat calvarial defect model by controlled release of growth factors were estimated

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