scholarly journals The Modifying Effect of a Functional Variant at the miRNA Binding Site in E2F1 Gene on Recurrence of Oropharyngeal Cancer Patients with Definitive Radiotherapy

2018 ◽  
Vol 11 (3) ◽  
pp. 633-638 ◽  
Author(s):  
Hua Zhang ◽  
Erich Sturgis ◽  
Lijun Zhu ◽  
Zhongming Lu ◽  
Ye Tao ◽  
...  
Keyword(s):  
Binding Site ◽  
Cancer Patients ◽  
Oropharyngeal Cancer ◽  
Mirna Binding Site ◽  
Definitive Radiotherapy ◽  
Functional Variant ◽  
Modifying Effect

scholarly journals Effect of variation in miRNA-binding site (rs8176318) of the BRCA1 gene in breast cancer patients

2019 ◽  
Vol 49 (5) ◽  
pp. 1433-1438 ◽  
Author(s):  
Mushtaq AHMAD ◽  
Fazal JALIL ◽  
Mutiul HAQ ◽  
Aftab Ali SHAH
Keyword(s):  
Breast Cancer ◽  
Binding Site ◽  
Cancer Patients ◽  
Brca1 Gene ◽  
Mirna Binding Site ◽  
Breast Cancer Patients

scholarly journals Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 35015-35025 ◽  
Author(s):  
Xingming Chen ◽  
Erich M. Sturgis ◽  
Chengyuan Wang ◽  
Xiaoli Cao ◽  
Yuncheng Li ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Oropharyngeal Cancer ◽  
Definitive Radiotherapy

scholarly journals A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

2015 ◽  
Vol 36 (2) ◽  
pp. 622-630 ◽  
Author(s):  
Qiaoyun Chen ◽  
Rong Qin ◽  
Yue Fang ◽  
Hao Li ◽  
Yangchen Liu
Keyword(s):  
Gastric Cancer ◽  
Binding Site ◽  
Cancer Patients ◽  
Binding Sites ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Functional Variant ◽  
Gastric Cancer Patients

Background and Aims: Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs), were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809) on gastric cancer (GC) risk in a hospital-based case-control study in a Chinese Han population. Methods and Results: We genotyped the rs114673809 polymorphism in 345 gastric cancer patients and 376 cancer-free controls using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The functions of rs114673809 were investigated using a luciferase activity assay and validated by immunoblotting. We found that participants carrying the rs114673809 AA genotype or A allele had a significantly increased risk of gastric cancer (OR = 1.667, 95% CI = 1.044-2.660, P = 0.034; OR = 1.261, 95% CI = 1.017-1.563, P = 0.037, respectively) compared to those carrying the GG genotype and G allele. In addition, rs114673809 modified the binding of hsa-miR-214 to MTHFR as well as MTHFR protein levels in gastric cancer patients. Conclusion: Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.

scholarly journals A genetic variant within MDM4 3′UTR miRNA binding site is associated with HPV16‐positive tumors and survival of oropharyngeal cancer

2019 ◽  
Vol 58 (12) ◽  
pp. 2276-2285 ◽  
Author(s):  
Yang Zhang ◽  
Erich M. Sturgis ◽  
Peng Wei ◽  
Hongliang Liu ◽  
Ziqiao Wang ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Genetic Variant ◽  
Mirna Binding Site

scholarly journals A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (21) ◽  
pp. 34630-34642 ◽  
Author(s):  
Chiao-Wen Lin ◽  
Ying-Erh Chou ◽  
Chia-Ming Yeh ◽  
Shun-Fa Yang ◽  
Chun-Yi Chuang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Binding Site ◽  
Squamous Cell ◽  
Mirna Binding Site ◽  
Functional Variant

scholarly journals A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk of recurrence in patients with oropharyngeal cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34472-34479 ◽  
Author(s):  
Chengyuan Wang ◽  
Erich M. Sturgis ◽  
Xingming Chen ◽  
Qingyi Wei ◽  
Guojun Li
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Risk Of Recurrence ◽  
Functional Variant

scholarly journals A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk and HPV-positive tumours of oropharyngeal cancer

2015 ◽  
Vol 51 (11) ◽  
pp. 1415-1423 ◽  
Author(s):  
Yang Zhang ◽  
Erich M. Sturgis ◽  
Yan Sun ◽  
Chuanzheng Sun ◽  
Qingyi Wei ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Functional Variant

scholarly journals TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy

2018 ◽  
Vol 24 (9) ◽  
pp. 2225-2233 ◽  
Author(s):  
Ye Tao ◽  
Erich M. Sturgis ◽  
Zhigang Huang ◽  
Ying Wang ◽  
Peng Wei ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Clinical Outcomes ◽  
Genetic Variants ◽  
Oropharyngeal Cancer ◽  
Definitive Radiotherapy
Sign in / Sign up

Export Citation Format

Share Document