scholarly journals A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

2015 ◽  
Vol 36 (2) ◽  
pp. 622-630 ◽  
Author(s):  
Qiaoyun Chen ◽  
Rong Qin ◽  
Yue Fang ◽  
Hao Li ◽  
Yangchen Liu
Keyword(s):  
Gastric Cancer ◽  
Binding Site ◽  
Cancer Patients ◽  
Binding Sites ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Functional Variant ◽  
Gastric Cancer Patients

Background and Aims: Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs), were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809) on gastric cancer (GC) risk in a hospital-based case-control study in a Chinese Han population. Methods and Results: We genotyped the rs114673809 polymorphism in 345 gastric cancer patients and 376 cancer-free controls using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The functions of rs114673809 were investigated using a luciferase activity assay and validated by immunoblotting. We found that participants carrying the rs114673809 AA genotype or A allele had a significantly increased risk of gastric cancer (OR = 1.667, 95% CI = 1.044-2.660, P = 0.034; OR = 1.261, 95% CI = 1.017-1.563, P = 0.037, respectively) compared to those carrying the GG genotype and G allele. In addition, rs114673809 modified the binding of hsa-miR-214 to MTHFR as well as MTHFR protein levels in gastric cancer patients. Conclusion: Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.

A functional variant at miR-24 binding site in B7-H2 alters susceptibility to gastric cancer in a Chinese Han population

2013 ◽  
Vol 56 (1-2) ◽  
pp. 98-103 ◽  
Author(s):  
Panpan Yang ◽  
Rong Tang ◽  
Jianjie Zhu ◽  
Lingting Zou ◽  
Ruirong Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Binding Site ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Functional Variant

scholarly journals Influence of CMTM8 polymorphisms on Lung Cancer Susceptibility in the Chinese Han Population

2020 ◽  
Author(s):  
Jiamin Wu ◽  
Yao Sun ◽  
Zichao Xiong ◽  
Fanglin Niu ◽  
Yuanwei Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Lung Cancer Risk ◽  
Lung Squamous Cell Carcinoma ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Lung Cancer Patients ◽  
Increased Risk

Abstract Objective: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population.Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs).Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk in codominant (adjusted OR = 1.57, 95%CI: 1.01-2.42, p = 0.044) and dominant (adjusted OR = 1.54, 95%CI: 1.01-2.36, p = 0.047)models. After gender stratification analysis,weobserved that rs6771238 was related to an increased risk of lung squamous cell carcinoma, while rs6771238 was associated with anincreased risk of lung adenocarcinoma. Rs9835916 and rs1077868 were correlated with lung cancer staging.Rs9835916 was linked to increased risk of lymph node metastasis in lung cancer patients. Conclusions: Our study firstly reported that the CMTM8 polymorphisms were a risk factors for lung cancer, which suggested the potential roles of CMTM8 in the development of lung cancerin Chinese Han population.

scholarly journals A Functional Variant at miR-520a Binding Site in PIK3CA Alters Susceptibility to Colorectal Cancer in a Chinese Han Population

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lifang Ding ◽  
Zao Jiang ◽  
Qiaoyun Chen ◽  
Rong Qin ◽  
Yue Fang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Binding Site ◽  
Target Genes ◽  
Chinese Han Population ◽  
Mrna Levels ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Peripheral Blood Mononucleated Cell ◽  
Risk Of Cancer

An increasing body of evidence has indicated that polymorphisms in the miRNA binding site of target gene can alter the ability of miRNAs to bind their target genes and modulate the risk of cancer. We aimed to investigate the association between a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3′-UTR and the risk of colorectal cancer (CRC) in a Chinese Han population. The polymorphism rs141178472 was analyzed in a case-control study, including 386 CRC patients and 394 age- and sex-matched controls; the relationship between the polymorphism and the risk of colorectal cancer was examined. Individuals carrying the rs141178472 CC genotype or C allele had an increased risk of developing CRC (CC versus TT, OR (95% CI): 1.716 (1.084–2.716),P=0.022; C versus T, OR (95% CI): 1.258 (1.021–1.551),P=0.033). Furthermore, the expression of PIK3CA was detected in the peripheral blood mononucleated cell of CRC patients, suggesting that mRNA levels of PIK3CA might be associated with SNP rs141178472. These findings provide evidence that a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3′-UTR may play a role in the etiology of CRC.

scholarly journals Influence of CMTM8 polymorphisms on Lung cancer susceptibility in the Chinese Han population

2019 ◽  
Author(s):  
Jiamin Wu ◽  
Yao Sun ◽  
Zichao Xiong ◽  
Fanglin Niu ◽  
Yuanwei Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Lung Cancer Risk ◽  
Cancer Staging ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Lung Cancer Patients ◽  
Increased Risk

Abstract Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population. Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis were used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk (p < 0.05). In stratified analysis, rs6771238 was related to an increased risk of lung squamous cell carcinoma (p < 0.05), rs6771238 was associated with an increased risk of lung adenocarcinoma (p < 0.05), rs9835916 and rs1077868 were correlated with lung cancer staging (p < 0.05), and rs9835916 was correlated with an increased risk of lymph node metastasis in lung cancer patients (p < 0.05). Additionally, Haplotype analysis illuminated that haplotypes GG and AG were closely correlated with lung cancer staging, and haplotype AG was correlated with an increased lung cancer risk among individuals older than 50 years (p < 0.05). Conclusions: Our study firstiy reported that the CMTM8 polymorphisms were risk factors for lung cancer in Chinese Han population. These findings also suggested the potential roles of CMTM8 in the development of lung cancer.

MiR-143HG Gene Polymorphisms as Risk Factors for Gastric Cancer in Chinese Han Population

2020 ◽  
Vol 20 (7) ◽  
pp. 536-547 ◽  
Author(s):  
Jianfeng Liu ◽  
Haiyue Li ◽  
Yuanwei Liu ◽  
Yao Sun ◽  
Jiamin Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Codominant Model ◽  
Stratified Analysis ◽  
First Time

Background: MicroRNA (miRNA) is a pivotal regulator of the occurrence and development of various cancers. And gastric cancer (GC) is one of the most common and deadly cancers in the world. The aim of this study is to explore whether the microRNA-143 host gene (miR-143HG) polymorphisms are correlated with the risk of GC. Methods: 5 single-nucleotide polymorphisms (SNPs) were genotyped among 506 patients and 500 healthy controls in Han Chinese population. Multiple genetic models, stratification analysis and haplotype analysis were used to evaluate the association between miR-143HG polymorphisms and GC risk by calculating odds ratios (ORs), 95% confidence intervals (CIs). Results: Our results indicated that rs11168100 was associated with decreased risk of GC under the Codominant model (OR = 0.67, 95%CI = 0.52-0.88, p = 0.003), and under the Dominant model (OR = 0.72, 95%CI = 0.56-0.92, p = 0.009). Rs353300 was associated with increased risk of GC under the Recessive model (OR = 1.41, 95%CI = 1.06-1.87, p = 0.017). Further, rs11168100 and rs353300 were correlated with the susceptibility of GC (age > 60 years), and three SNPs (rs12654195, rs353303, and rs353300) were related with the risk of GC (age ≤ 60 years). In addition, two SNPs (rs12654195 and rs11168100) were found to be associated with decrease in the susceptibility of GC in the female subgroup. Rs353300 represented two-sided roles in the occurrence and development of GC in female. Finally, rs3533003 was associated with decreased risk of GC in stratified analysis of lymph node metastasis. Conclusion: For the first time, our results provide some evidence on the polymorphisms of miR-143HG associated with GC risk in the Chinese Han population.

Association between polymorphisms of microRNA-binding sites in integrin genes and gastric cancer in Chinese Han population

Tumor Biology ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 2785-2792 ◽  
Author(s):  
Xingbo Song ◽  
Huiyu Zhong ◽  
Juan Zhou ◽  
Xuejiao Hu ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Binding Sites ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Influence of CMTM8 polymorphisms on Lung cancer susceptibility in the Chinese Han population

2019 ◽  
Author(s):  
Jiamin Wu ◽  
Yao Sun ◽  
Zichao Xiong ◽  
Fanglin Niu ◽  
Yuanwei Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Lung Cancer Risk ◽  
Cancer Staging ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Lung Cancer Patients ◽  
Increased Risk

Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population. Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk (p < 0.05). In stratified analysis, rs6771238 was related to increased risk of lung squamous cell carcinoma (p < 0.05), rs6771238 was associated with increased risk of lung adenocarcinoma (p < 0.05), rs9835916 and rs1077868 were correlated with lung cancer staging (p < 0.05), and rs9835916 was correlated with increased risk of lymph node metastasis in lung cancer patients (p < 0.05). Additionally, Haplotype analysis illuminated that haplotypes GG and AG were closely correlated with lung cancer staging, and haplotype AG was correlated with increased lung cancer risk among individuals older than 50 years (p < 0.05). Conclusions: Our study first reported that the CMTM8 polymorphisms were risk factors for lung cancer in Chinese Han population. These findings also suggested the potential roles of CMTM8 in the development of lung cancer.

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